DNA Binding Domain (DBD)
MMPP Attenuates Non-Small Cell Lung Cancer Growth by Inhibiting the STAT3 DNA-Binding Activity via Direct Binding to the STAT3 DNA-Binding Domain
... direct binding to the SH2 domain [6, ...SH2 domain remains the main focus for designing small-molecule inhibitors, there has been a growing interest in developing specific inhibitors that can target ...
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Autoimmunogenicity of the helix-loop-helix DNA-binding domain
... native DNA, and its high immunogenicity when presented in complex with the DNA-binding proteins indicate that the latter might contain molecular triggers of anti-DNA ...main ...
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Functional Mapping of the DNA Binding Domain of Bovine Papillomavirus E1 Protein
... for binding-functional E1DBD mutants using two different ...plasmid DNA extraction from the yeast clones, we generated PCR products from the E1DBD ORF, which were then processed as de- scribed in Materials ...
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Human herpesvirus 6B origin-binding protein: DNA-binding domain and consensus binding sequence.
... a DNA-binding assay that the human herpesvirus 6B (HHV-6B) replication origin has a structure similar to those of alphaherpesviruses, although the HHV-6B and herpes simplex virus type 1 (HSV-1) ...
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The DNA Binding Domain of a Papillomavirus E2 Protein Programs a Chimeric Nuclease To Cleave Integrated Human Papillomavirus DNA in HeLa Cervical Carcinoma Cells
... viral DNA binding domain to act with its predicted specificity in ...encode DNA bind- ing proteins with greater specificity than the papillomavirus E2 protein and may serve as the source of ...
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Monoclonal Antibodies against the Minimal DNA-Binding Domain in the Carboxyl-Terminal Region of Human Immunodeficiency Virus Type 1 Integrase
... minimum DNA-binding domain (MDBD) (amino acids [aa] 220 to 270) is required for the integration ...Their binding to HIVIN inhibited terminal cleavage and strand transfer activities but not ...
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Surface Mutagenesis of the Bovine Papillomavirus E1 DNA Binding Domain Reveals Residues Required for Multiple Functions Related to DNA Replication
... bility is that these mutations affect some aspect of replication control, which is required for DNA replication in vivo but not in vitro. For example, it is likely that replication in vivo is controlled by ...
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Characterization of the DNA-Binding Domain of the Bovine Papillomavirus Replication Initiator E1
... E2 binding site (nt 6), (ii) an ori with a point mutation in the half-site distal to the E2 binding site (7942), or (iii) an ori with an 8-bp XhoI linker insertion between the two half-sites ...reduced ...
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Characterization of a major DNA-binding domain in the herpes simplex virus type 1 DNA-binding protein (ICP8).
... ICP8, the major DNA-binding protein from herpes simplex virus type 1 HSV-1, belongs to a class of singlestranded DNA-binding proteins.. These proteins are required for DNA replication, p[r] ...
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How an essential Zn2Cys6 transcription factor PoxCxrA regulates cellulase gene expression in ascomycete fungi?
... DBD: DNA‑binding domain; DEGs: differentially expressed genes; EG: endo‑β‑1,4‑glucanase; EMSA: electrophoretic mobility shift assay; FPase: filter paper cellulase; FPKM: fragments per kilobase of ...
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Separation of the complex DNA binding domain of EBNA-1 into DNA recognition and dimerization subdomains of novel structure.
... These mutants plus the availability of a new monoclonal antibody against EBNA-1, EBNA.OTlx, allowed us to separate the individual DNA binding and dimerization domains and to gain some in[r] ...
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Targeted gene suppression by inducing de novo DNA methylation in the gene promoter
... catalytic domain of these lysine methyltransferases shares a conserved structural fold called the SET domain ...GAL4 DNA-binding domain, it effectively inhibits the target promoter in ...
11
Mechanisms of simian virus 40 T-antigen activation by phosphorylation of threonine 124.
... minimal DNA binding do- main could lead to a variety of related changes in T-antigen ...minimal DNA binding domain of T antigen with pentanucleotide repeats of core origin DNA in ...
7
Transcriptional Activation Domains of the Candida albicans Gcn4p and Gal4p Homologs
... tion domain; CIp-lexA-GCN4 ⌬ 247-323, CIp-lexA-GCN4 ⌬ 161- 323, CIp-lexA-GCN4 ⌬ 123-323, and CIp-lexA-GCN4 ⌬ 82-323 were as active as full-length CIp-lexA-GCN4 in both the lacZ background and HIS1 ...activation ...
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Mechanism of environmentally driven conformational changes that modulate H-NS DNA-bridging activity
... the DNA-binding domain interacts with other parts of the protein ...the DNA-binding domain interacts with the dimerization domain, rendering the ...
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Competition for DNA Binding Sites between the Short and Long Forms of E2 Dimers Underlies Repression in Bovine Papillomavirus Type 1 DNA Replication Control
... vitro DNA rep- lication and that this repression was dependent upon the DNA binding domain of the repressor led us to reexamine the role of E2 DNA binding sites for the cell-free ...
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Molecular and genetic analysis of the toxic effect of RAP1 overexpression in yeast.
... Viable mutations within the Raplp DNA-binding do- main and adjacent region are nontoxic: The identifica- tion of point mutations within the Raplp DNA-binding domain that abo[r] ...
10
Elucidation the toxicity mechanism of metal oxide and carbon based nanoparticles with p53 protein using molecular docking approach
... comparative binding and toxicity impact of metal oxide and carbon based nanoparticles on p53 DNA binding ...higher binding affinity as compared to the carbon based nanoparticles and their ...
6
Structure, Function, and Characterization of Proteins and Small Molecules Involved in Biofilm Regulation/Inhibition and Apoptosis
... directly binding to and inhibiting, the transcriptional activities of the global transition state regulator protein ...was binding to DNA targets, and no AbrB-protein interactions ...N-terminal ...
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Cloning and expression of an equine herpesvirus 1 origin-binding protein.
... In order to confirm that the C-terminal DNA-binding domain of EHV-1 OBP was mediating the same sequencespecific binding as the wild-type protein, in vitro-expressed del 1-499 was used to[r] ...
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