DNA copy number
CopywriteR: DNA copy number detection from off target sequence data
... of copy number ...First, copy number information from non-exonic regions is absent and can only be inferred from the exonic ...for DNA copy number profiling from WES apply ...
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Classification of human cancers based on DNA copy number amplification modeling
... of DNA copy number amplifications, and identified 111 specific amplification ...of DNA copy number amplification" for ...continuous DNA copy number ...
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The potential role for use of mitochondrial DNA copy number as predictive biomarker in presbycusis
... Mitochondrial DNA sequence variation has a critical role in ...mitochondrial DNA copy number, an important biomarker in many other diseases, and presbycusis is ...
6
Genome-wide analysis of DNA copy-number changes using cDNA microarrays.pdf
... of DNA copy-number ...measure DNA copy-number changes by cDNA microarray ...Genomic DNA samples isolated from tumour cells and normal blood leukocytes are labelled with ...
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Differential mitochondrial DNA copy number in three mood states of bipolar disorder
... Mitochondrial DNA copy number (mtDNAcn) that re- flects the mitochondrial function and biogenesis could be measured per cell [12]. Abnormal mtDNAcn has been suggested to associate with various ...
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Whole genome DNA copy number changes identified by high density oligonucleotide arrays
... in DNA copy number are one of the hallmarks of the genetic instability common to most human ...The copy number algorithm jointly uses PM intensity and discrimination ratios between ...
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Pre-diagnostic leukocyte mitochondrial DNA copy number and risk of lung cancer
... Mitochondrial DNA (mtDNA) is closely located to the source of reactive oxidative stress (ROS) production and is extremely susceptible to oxidative or other genotoxic damage due to the absence of protective ...
6
DiNAMIC - a method for assessing the statistical signficance of DNA copy number aberrations
... DNA copy number aberrations (CNAs) are commonly found in tumor tissue, and can range from losses (deletions) of one or both copies of chromosomal regions to gains of numer- ous additional copies ...
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Mitochondrial DNA copy number in peripheral blood leukocytes and the aggressiveness of localized prostate cancer
... mitochondrial DNA copy number (mtDNAcn) in peripheral blood leukocytes at diagnosis was associated with an increased risk of the aggressive form of the tumor and disease progression among localized ...
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Integrative analysis of DNA copy number, DNA methylation and gene expression in multiple myeloma reveals alterations related to relapse
... of DNA copy number, DNA methylation and gene expression was conducted in matched diagnosis and relapse samples from MM ...and DNA losses were significantly more frequent in relapse than ...
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Modulation of mitochondrial DNA copy number in a model of glioblastoma induces changes to DNA methylation and gene expression of the nuclear genome in tumours
... Furthermore, it has been reported that the genomes of low grade and secondary glioblastomas are extensively methylated to support the tumorigenic transcriptome that they exhibit [32, 38–40, 43]. This is further supported ...
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A genome-wide association study of mitochondrial DNA copy number in two population-based cohorts
... with DNA ex- tracted from both white cells and whole blood: it is pos- sible that combining individuals with DNA prepared from multiple sources could lead to preferential detec- tion of loci associated with ...
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DNA copy number evolution in Drosophila cell lines
... These copy number changes were not due to passenger effects as stoichiom- etry-preserving changes in copy number were still evident after filtering for nearby genes (P = ...high copy ...
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Ultra-Sensitive Mutation Detection and Genome-Wide DNA Copy Number Reconstruction by Error-Corrected Circulating Tumor DNA Sequencing.
... 30. Kim ST, Lee WS, Lanman RB, Mortimer S, Zill OA, Kim K-M, et al. Prospective blinded study of somatic mutation detection in cell-free DNA utilizing a targeted 54-gene next generation sequencing panel in ...
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DNA copy number alterations and PPARG amplification in a patient with multifocal bladder urothelial carcinoma
... detect copy number variations (CNVs) that may be involved with tumor recurrence and ...The copy number level of these genes would seem inversely mutually correlated and highly dependent on ...
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Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data
... base, copy number status and fraction of aberrant tumor cells present in each cancer sample, CaVEMan generates a probability score for potential genotypes at each genomic ...partner DNA sequences ...
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Leukocyte mitochondrial DNA copy number, anthropometric indices, and weight change in US women
... the number of PCR cycles required to detect a signal over background fluorescence and is inversely proportional to the amount of ...gene copy number to genomic single-copy gene copy ...
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Human Papillomavirus (HPV) DNA Copy Number Is Dependent on Grade of Cervical Disease and HPV Type
... in copy number with increasing dysplasia, combining results for all HPV types does demonstrate an over- all correlation with disease ...sample DNA content increases with increasing cervical disease ...
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Elevated mitochondrial DNA copy number in peripheral blood cells is associated with childhood autism
... mtDNA copy number in lymphocytes was not significantly different in overall ...higher copy numbers of mtDNA when compared with healthy children ...mtDNA copy number may be caused by ...
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DNA Copy Number Variation in a Cohort of Healthy Australian Women
... of copy number change between adjacent ...in copy number state and uses a large population reference source to index the B allele frequency, the latter providing more accurate estimation of ...
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