DNA copy number changes
Genome-wide analysis of DNA copy-number changes using cDNA microarrays.pdf
... of DNA copy-number ...measure DNA copy-number changes by cDNA microarray ...Genomic DNA samples isolated from tumour cells and normal blood leukocytes are labelled ...
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Whole genome DNA copy number changes identified by high density oligonucleotide arrays
... in DNA copy number are one of the hallmarks of the genetic instability common to most human ...The copy number algorithm jointly uses PM intensity and discrimination ratios between ...
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Genome-Wide Analysis of DNA Copy Number Changes in Liver Steatosis
... in the two patients without steatosis. Patient Bio 113 exhibited a gain of GSTT1 by aCGH, however the Taqman assay did not show increase in number of copies, probably reflecting differences in the sensitivity ...
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Deletion of chromosome 4q predicts outcome in Stage II colon cancer patients
... of DNA copy number changes and clinical outcome in colorectal cancer ...small number of studies the prognostic value of chromosomal aberrations limited to patients with early stage ...
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Copy number and gene expression differences between African American and Caucasian American prostate cancer
... both DNA copy number changes and gene expression profiles in a cohort of AA and CA PCa patients using BAC-based array comparative genomic hybridization (aCGH), oligo-based aCGH, and gene ...
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Copy number variations and cancer
... the DNA copy number changes of 242 pediatric acute lymphoblastic leukemia (ALL) patients, including 192 with B-progenitor leukemia (B-ALL) and 50 with T-lineage leukemia ...the number ...
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Evaluation of high resolution microarray platforms for genomic profiling of bone tumours
... for DNA copy number changes in duplicate using four different high-resolution oligonucleotide microarray platforms; Affymetrix Genome-Wide Human SNP Array ...
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Detecting copy number changes in genomic DNA - MAPH and MLPA
... large number of transcription ...the DNA binding transcription factors and the RNA polymerase II ...large number of other proteins, for example the transcription factor p53 (Gu and Roeder ...
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Deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicine
... undocumented DNA mutations discovered are likely to affect clinical response to marked therapeutics and may be good drug ...wide DNA muta- tion, DNA copy number, RNA levels and ...
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Copy number changes and methylation patterns in an isodicentric and a ring chromosome of 15q11-q13: report of two cases and review of literature
... bisulfate-treated DNA, MS-PCR and MS-MLPA, have been introduced to define methyla- tion pattern for sSMC(15)s [21, 22, ...in copy number ...detect copy num- ber changes and DNA ...
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Increased mitochondrial DNA deletions and copy number in transfusion-dependent thalassemia
... redox environment (23, 24). Leukocytes from healthy individuals with elevated markers of oxidative stress show an increase in Mt/N (18). This increase in mitochondrial content is regarded as an adaptation to oxidant ...
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Classification of human cancers based on DNA copy number amplification modeling
... genomic changes underlie the cancer phenotype, DNA copy number amplification is a justified foundation for ...phenotypic changes in cancer cells and contribute to the clinical ...
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Tensorial blind source separation for improved analysis of multi omic data
... To assess this, we here benchmark our novel tensorial BSS algorithm against some of the most popular and pow- erful algorithms for inferring sources of variation from multi-omic data, including JIVE (joint and individual ...
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Differential mitochondrial DNA copy number in three mood states of bipolar disorder
... the defects or impairment. Excessive oxidative stresses in pathological conditions may induce structural and functional changes of mitochondrial [5]. Postmortem, brain imaging, genetic and peripheral cells studies ...
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DNA copy number alterations and PPARG amplification in a patient with multifocal bladder urothelial carcinoma
... detect copy number variations (CNVs) that may be involved with tumor recurrence and ...genetic changes were found in different tumors of the same ...The copy number level of these genes ...
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Copy number variation of ribosomal DNA and Pokey transposons in natural populations of Daphnia
... gene number with TE Display, so the dynamics of rPo- key have not yet been ...R2 number remained relatively constant through time, but changes in R1 number were strongly correlated with ...
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High-resolution analysis of copy number alterations and associated expression changes in ovarian tumors
... measuring copy number gains or ...measure copy number changes in ovarian serous carcinoma ...of copy number changes across the genome, focusing on rare ...
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Copy number variations in urine cell free DNA as biomarkers in advanced prostate cancer
... limited number of samples for developing such classifiers is agnostic of specific gene/ region changes and uses an algorithmic summation of the most common genetic abnormalities in ...genomic changes ...
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DNA Copy Number Variation in a Cohort of Healthy Australian Women
... of copy number change between adjacent ...predict changes in copy number state and uses a large population reference source to index the B allele frequency, the latter providing more ...
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Mitochondrial DNA copy number in peripheral blood leukocytes and the aggressiveness of localized prostate cancer
... These changes could result in a stronger tolerance to hypoxia and reduced dependence on mitochondrial oxidative phosphorylation, thus conferring growth advantage to tumor cells [26, 31, ...
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