DNA damage checkpoint pathway
DNA damage checkpoint pathway modulates the regulation of skeletal growth and osteoblastic bone formation by parathyroid hormone-related peptide
... the DNA damage response ...decreased DNA damage response. These data thus indicate that the DNA damage checkpoint pathway may play role as a downstream target in ...
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A DNA Damage Checkpoint Pathway Coordinates the Division of Dikaryotic Cells in the Ink Cap Mushroom Coprinopsis cinerea
... The DNA damage response (DDR) pathway detects dam- aged as well as unreplicated DNA and coordinates its repair with the cell cycle progression (Abraham 2001; Nyberg et ...the DNA repair ...
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Regulation of Septum Formation in Aspergillus nidulans by a DNA Damage Checkpoint Pathway
... Figure 8.—A branched regulatory pathway controls the cell types ( Fiddy and Trinci 1976; Harris 1997; timing of septum formation in predivisional hyphal cells. Dis- Kaminskyj and Hamer 1[r] ...
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Regulation of DNA Replication Machinery by Mrc1 in Fission Yeast
... replication checkpoint: To monitor the replication ef- ficiency of orp1-4 and sna41-928 cells at their respective semipermissive temperatures, we examined the incor- poration of the thymine analog BrdU into ...
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The Drosophila chk2 Gene loki Is Essential for Embryonic DNA Double-Strand-Break Checkpoints Induced in S Phase or G2
... to DNA damage or DNA replication blocks in various ...MMS-induced DNA damage checkpoint and the HU-induced DNA replication checkpoint during larval ...a ...
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The conservation of genotoxic stress-induced morphological changes in yeasts
... slow DNA synthesis are responsible for the induction of filamentous differentiation through Mec1-Rad53-Swe1-Cdc28- Clb2, as has been demonstrated earlier ...temperatures, DNA polymerase and DNA ...
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New combinatorial strategies to improve the PARP inhibitors efficacy in the urothelial bladder Cancer treatment
... immune checkpoint inhibitors (ICIs) have been introduced for mUBC as second-line treat- ment of post platinum-based chemotherapy or for cisplatin-inelegibile ...transduction pathway, the monoclonal ...
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Overlapping Roles of the Spindle Assembly and DNA Damage Checkpoints in the Cell-Cycle Response to Altered Chromosomes in Saccharomyces cerevisiae
... of checkpoint pathways involved in responding to stalled replication and DNA ...MEC1 pathway is the cell’s most sensitive DNA-responsive ...to DNA-damaging agents such as MMS and ...
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Rpd3L Contributes to the DNA Damage Sensitivity of Saccharomyces cerevisiae Checkpoint Mutants
... other DNA-damaging agents including UV radiation, camptothecin (CPT), and HU, but this suppression was never as striking as that seen in MMS (Figure ...to DNA damage (Figure ...mec1D ...
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Reconstitution of a human ATR-mediated DNA damage checkpoint prespone [sic]
... The DNA damage checkpoint is a signal transduction pathway that coordinates the cell cycle with other cellular responses and thus prevents the segregation of damaged ...to DNA ...
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Fanconi Anemia FANCM/FNCM-1 and FANCD2/FCD-2 Are Required for Maintaining Histone Methylation Levels and Interact with the Histone Demethylase LSD1/SPR-5 in Caenorhabditis elegans
... of DNA damage repair has attracted more attention to the fi eld in recent ...in DNA damage repair, and only a few studies have focused on the roles of histone demethylases in germline ...FA ...
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Spy1 Regulation of the DNA Damage Response; Checkpoint Activation and Cellular Senescence
... as DNA damage-induced breaks, repair mechanisms like non-homologous end joining (NHEJ) are able to join any two dysfunctional chromosomal ends and lead to chromosomal fusions by recombination ...active ...
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Working hard for recovery: mitotic kinases in the DNA damage checkpoint
... other checkpoint factors, such as NBS1 in Nijmegen breakage syndrome, Mre11 in AT-like disorder, ATR in Seckel syndrome, Chk2 and p53 in Li-Fraumeni syndrome ...intact DNA damage pathway, and ...
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Spontaneous Chromosome Loss in Saccharomyces cerevisiae Is Suppressed by DNA Damage Checkpoint Functions
... the pathway to unregulated ...Defective DNA replication, repair, and recombination can significantly increase the frequency of spontane- ous genomic ...Recently, DNA damage checkpoint ...
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Antagonism of Chk1 Signaling in the G2 DNA Damage Checkpoint by Dominant Alleles of Cdr1
... of checkpoint and cell cycle mutants to establish whether a normal pattern of signaling was present in these cells and to attempt to decipher where in the checkpoint pathway Chk1 signaling is ...
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Checkpoint kinase inhibitor AZD7762 strongly sensitises urothelial carcinoma cells to gemcitabine
... of checkpoint kinases, can strongly sensitise UCCs to the ribonucleotide reductase inhibitor ...G2 checkpoint activation induced by gemcitabine and especially with persistence of unrepaired DNA ...
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A conserved Polϵ binding module in Ctf18 RFC is required for S phase checkpoint activation downstream of Mec1
... downstream checkpoint kinase at defective replica- tion forks ...template DNA at replication forks ...template DNA at replication forks, where it serves as a processivity factor for DNA ...
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RBX1/ROC1-SCF E3 ubiquitin ligase is required for mouse embryogenesis and cancer cell survival
... altered DNA damage response commonly seen in cancer cells after RBX1 silencing can also be observed in RBX1- p27 double null embryos and if so, its contribution to the embryonic lethality in the later ...
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DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts
... of checkpoint signaling, including the blocks to mitosis and further DNA replication, activation of ATR kinase, and physical association of Rad17 with chroma- ...the DNA duplex before replication may ...
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Cell cycle checkpoint in cancer: a therapeutically targetable double-edged sword
... G2/M checkpoint, Wee1 kinase controls proper timing of mitosis onset by perform- ing inhibitory phosphorylation of Cdk1 ...extensive DNA damage, micronuclei forma- tion and ultimately apoptotic death ...
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