DNA damage signaling
DNA Damage Signaling Is Required for Replication of Human Bocavirus 1 DNA in Dividing HEK293 Cells
... a DNA damage response (DDR) (35), we hypothesized that replication of the HBoV1 duplex genome in HEK293 cells likewise induces this ...Viral DNA replication centers stained positive with anti-NS1C ...
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Polo-like kinase 4 at the nexus of epigenetic modifications and the DNA damage signaling network
... of DNA-modifying drugs on the epigenetic profile of PLKs and their expression may provide some insight as to how these highly conserved and essential cell cycle-dependent kinases are impacted during ...
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DNA Damage Response Signaling Triggers Nuclear Localization of the Chicken Anemia Virus Protein Apoptin
... of DNA damage as a result of DNA replication irregularities during the S phase of the cell ...cycle. DNA damage can result from the collision of replication forks, which then stall and ...
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Recombinant Adeno-Associated Viral Vectors Are Deficient in Provoking a DNA Damage Response
... cellular DNA damage signaling in several ...AAV2 DNA has recently been reported (5, 35), and such binding acts to limit viral replication and ...cellular DNA recombination and repair ...
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PubMedCentral-PMC4861496.pdf
... UV-induced DNA Damage Signaling Exhibit Different Pro- files in Cycling and Non-cycling Cells—Previous studies com- paring UV-induced DNA damage signaling in cycling and non- ...
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Simian Virus 40 Large T Antigen Disrupts Genome Integrity and Activates a DNA Damage Response via Bub1 Binding
... of DNA damage response signaling, which is required for efficient viral ...the damage response and, if so, what the genetic requirements and functional consequences might ...key DNA ...
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Spy1 Regulation of the DNA Damage Response; Checkpoint Activation and Cellular Senescence
... The DNA damage-signaling pathway is a coordinated phosphorylation-based signaling network that has evolved to maintain genomic integrity in normal cells and reduce cancer cell ...of ...
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PubMedCentral-PMC5837509.pdf
... In conclusion, this study provides an analysis of HTS and genomics-based data on a compound that is of high interest from the regulatory perspective. Emerging methods were used to evaluate the HTS data, including mapping ...
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The Homologous Recombination Repair Pathway is Associated with Resistance to Radiotherapy in Nasopharyngeal Carcinoma
... to DNA damage, many proteins involved in the DNA damage signaling pathway, including BRCA1, RPA1, and RAD51, are quickly recruited into IR-induced DSB sites in mammalian cells, and ...
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Ataxia Telangiectasia-Mutated Damage-Signaling Kinase- and Proteasome-Dependent Destruction of Mre11-Rad50-Nbs1 Subunits in Simian Virus 40-Infected Primate Cells
... (ATM)-mediated DNA damage-signaling pathway is ac- tivated (15, ...Checkpoint signaling ordinarily arrests ongoing host DNA replication and delays cell cycle transitions, but in ...
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Radio-resistant mesenchymal stem cells: mechanisms of resistance and potential implications for the clinic
... onto DNA molecules or by creating free radicals that in turn interact with the DNA strands ...of DNA damage, including damage to DNA bases or the sugar backbone as well as ...
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Exploring the Association between Network, Cognitive, Structural Social Capital and the Risk of Clinical Depression in Taiwan
... To examine the effect of H2AX signaling in response to TS inhibition, we utilized three models that have reduced or eliminated H2AX expression. First, murine embryonic fibroblasts (MEFs) were generated by others, ...
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p16 and ARF: activation of teenage proteins in old age
... yet to be established. Studies focused on the tumor suppressor p53 have revealed diverse results regarding the role of this key component of the senescence path- way during aging. In mouse models, the deletion of p53 has ...
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MAPKinase signaling and AP-1-regulated gene expression in cellular responses to DNA damage
... panel). DNA damage occurring anywhere in the genome can be repaired by the GGR pathway, but DNA lesions that occur on the transcribed strand of an active gene and block RNA polymerase II progression ...
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5748.pdf
... or DNA damage in TCDD treated ...liver DNA after 30-week promotion by TCDD and diethylnitrosamine (DEN) initiation (48, ...and DNA single- strand ...and DNA single-strand breaks was ...
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Moser, Christina (2017): Novel treatment strategies and mechanisms of actin binding compounds in cancer therapy. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... after DNA damage induction with ...after DNA damage on the function of organelles was described ...for DNA damage repair was emphasized, by the results of SKBR3 cells, which ...
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A Synthetic Circuit For Control Of The Bacterial Dna Damage Response Without Dna Damage
... of DNA damage would be mutagenic on its ...of DNA damage, the SOS pathway is not sufficient for mutagenesis, suggesting instead that a DNA damage nidus is important for ...
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Activation of the DNA Damage Response Is a Conserved Function of HIV 1 and HIV 2 Vpr That Is Independent of SLX4 Recruitment
... the DNA damage response, regard- less of the ability of the Vpr protein to recruit SLX4, is also different from previous reports of studies performed using ei- ther an small interfering RNA (siRNA) approach ...
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The role of Plk4 in DNA damage pathways and entry into mitosis.
... Cdc25C, Cyclin B l nuclear accumulation is also necessary for mitotic entry to occur. Interestingly, evidence indicates that the initial activation of the Cdkl/Cyclin B complex occurs at the centrosome (Jackman et al., ...
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P300 inhibition enhances gemcitabine-induced apoptosis of pancreatic cancer
... gemcitabine-induced DNA damage, at least partially by HAT-dependent manner and targeting p300 HAT activity can enhance the therapeutic efficacy of gemcitabine against pancreatic ...
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