DNA damaging agents
The Yeast Histone Chaperone Chromatin Assembly Factor 1 Protects Against Double-Strand DNA-Damaging Agents
... double-strand DNA-damaging agents: The Saccharomyces cerevisiae CAF-1 complex is encoded by the genes CAC1, CAC2, and CAC3 (chromatin assembly complex ...double-strand DNA-damaging ...
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Synergy between histone deacetylase inhibitors and DNA- damaging agents is mediated by histone deacetylase 2 in colorectal cancer
... that DNA damaging agents allow the protein to stabilise and accumulate in the cell ...with DNA damage, since there is no p53 protein expression in H1299 ...
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Parainfluenza Virus Infection Sensitizes Cancer Cells to DNA-Damaging Agents: Implications for Oncolytic Virus Therapy
... to DNA-damaging agents raises a practical application for our work in terms of the resistance of some cancer cells to DNA-damaging ...increase DNA repair capabilities (36, ...of ...
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Enhanced nucleotide excision repair capacity in lung cancer cells by preconditioning with DNA-damaging agents
... in DNA damage response ...a DNA damage response to promote the apoptotic pathway [24, ...However, DNA repair pathways counteract this effect by repairing damaged DNA and restoring it to normal ...
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Mutation in the bimD gene of Aspergillus nidulans confers a conditional mitotic block and sensitivity to DNA damaging agents.
... It is likely that the sensitivity of bimD6 mutant strains to DNA-damaging agents at temperatures permissive for the mitotic defect is the result of partial loss of bimD f[r] ...
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Recombinogenic Effects of DNA-Damaging Agents Are Synergistically Increased by Transcription in Saccharomyces cerevisiae: New Insights Into Transcription-Associated Recombination
... by DNA-damaging agents in actively transcribed ...that DNA-damaging agents and transcription increase the frequency of initiation ...verted DNA repeats) that detect ...
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Pretreatment with DNA damaging agents permits selective killing of checkpoint deficient cells by microtubule active drugs
... prevented mitotic arrest caused by PTX (Figure 1, b and c). Mitotic arrest coincides with the appearance of round cells (Figure 1c, PTX) and culminates in cell death within 2 days. Pretreatment with doxoru- bicin ...
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DNA-damaging agents greatly increase the transduction of nondividing cells by adeno-associated virus vectors.
... DISCUSSION We have demonstrated that the transduction efficiency of AAV vectors on nondividing cells can be increased by more than 2 orders of magnitude by treatment with DNA-damaging ag[r] ...
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Characterization of G1 checkpoint control in the yeast Saccharomyces cerevisiae following exposure to DNA-damaging agents.
... Finally, in an at- tempt to characterize the specific signal(s) that triggers checkpoint arrest we have examined the G, arrest re- sponse to U V or ionizing radiation in mu[r] ...
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DNA-Repair Capacity in Down's Syndrome
... Unscheduled DNA synthesis assay: DNA excision-repair capacity was estimated by measuring UDS induced in vitro after treatment with DNA-damaging agents in peripheral lymphocytes by the ...
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Involvement of p53 in insulin-like growth factor binding protein-3 regulation in the breast cancer cell response to DNA damage
... causing DNA double-strand breaks, upregulate the tumor suppressor ...by DNA-damaging agents in breast cancer ...these agents in cells with high basal levels of IGFBP-3 (MDA-MB-231, ...
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<p>Association of <em>XRCC1</em>, <em>XRCC2</em> and <em>XRCC3</em> Gene Polymorphism with Esophageal Cancer Risk</p>
... XRCC3 gene mainly repairs using the HR pathway and in vitro studies revealed high sensitivity to DNA damaging agents in cells with XRCC3 gene knockouts. 89 No associa- tion of XRCC3 p.Thr241Met ...
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Overlapping Roles of the Spindle Assembly and DNA Damage Checkpoints in the Cell-Cycle Response to Altered Chromosomes in Saccharomyces cerevisiae
... and DNA damage. The MEC1 pathway is the cell’s most sensitive DNA-responsive ...to DNA-damaging agents such as MMS and ionizing radiation requires R A D9, the R A D24 epistasis group, ...
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Combining DNA damaging therapeutics with immunotherapy: more haste, less speed.
... DNA-damaging agents are mutagenic, as demonstrated by the increased risk of secondary cancers following treatment with radiotherapy or chemotherapeutics such as etoposide and also, by the mutational ...
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Proteolytic systems and AMP-activated protein kinase are critical targets of acute myeloid leukemia therapeutic approaches
... Importantly, autophagy may act as a “double-edged sword” in cancer [32]. In early tumorigenesis, it seems to be cancer preventing, however, in an established tumor, autophagy might help cancer cells to survive under ...
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Index Catalog // Carolina Digital Repository
... of DNA- damaging agents when p73 levels are lowest in normal cells to reduce toxicity but higher in tumor cells to increase ...the DNA repair protein XPA is elevated in Cry-deficient mouse ...
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Functional Conservation and Specialization among Eukaryotic Anti-Silencing Function 1 Histone Chaperones
... Chromatin disassembly and reassembly, mediated by histone chaperones such as anti-silencing function 1 (Asf1), are likely to accompany all nuclear processes that occur on the DNA template. In order to gain insight ...
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Cisplatin versus carboplatin in combination with paclitaxel as neoadjuvant regimen for triple negative breast cancer
... Therefore, there is interest in utilizing DNA-damaging agents, such as platinum drugs (cisplatin and carboplatin) to treat TNBC. Few trials have been designed to compare the efficacy and safety ...
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Studies on novel human DNA damage sensitive cell lines
... alkylating agents, as to what might be defective in this cell ...to DNA damaging agents, particularly 3 AB, is strongly reminiscent of the pattern of alkylating agent and ionizing radiation ...
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Interaction between the sbcC gene of Escherichia coli and the gam gene of phage lambda.
... T h e acquisition of an sbcC mutation conferred upon these strains essentially wild-type rates of growth and genetic recombination and resistance to DNA damaging agents; [r] ...
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