DNA double strand breaks (DSBs)
The Role of Long Non Coding RNAs in the Repair of DNA Double Strand Breaks
... DNA double strand breaks (DSBs) are abrasions caused in both strands of the DNA duplex following exposure to both exogenous and endogenous ...words: DNA repair, homologous ...
12
DNA double-strand breaks in human induced pluripotent stem cell reprogramming and long-term in vitro culturing
... monitoring DNA integ- rity is the detection of DNA double-strand breaks ...(DSBs). DSBs are a severe type of DNA damage that may cause irreversible changes in the ...
13
Early neuronal accumulation of DNA double strand breaks in Alzheimer’s disease
... which DNA damage increases with age and is exacerbated by multiple neurological disorders, including Alzheimer ’ s disease ...detect DNA double strand breaks (DSBs), the most ...
18
Dna Double Strand Breaks Suppress Expression Of The Rag Recombinase: Mechanisms And Consequences
... that DNA double strand breaks (DSBs) induced by a variety of genotoxic agents have a similar effect in suppressing mRNA expression of Rag1 and ...that DSBs activate ATM and Nemo ...
164
The Role of the Ku70 vWA Domain in the Response to DNA Double Strand Breaks
... repair DSBs by C-NHEJ if the ends are compatible (101, ...for DNA end binding. The binding of HR factors initiates DNA end resection to produce single-stranded DNA, which Ku does not have a ...
220
Molecular Mechanisms of H. pylori Induced DNA Double-Strand Breaks
... oxidative DNA damage leads to DSBs repair oxidative damaged DNA via BER, which is thought to be the primary repair pathways against oxidative DNA ...
30
LINC01094 triggers radio-resistance in clear cell renal cell carcinoma via miR-577/CHEK2/FOXM1 axis
... carcinoma; DSBs: DNA double-strand breaks; IR: Ionizing radiation; LINC01094: Long intergenic non-protein coding RNA 1094; KIRC: Kidney renal clear cell carcinoma; ATCC : American Type ...
10
Hypersensitivity of ataxia telangiectasia cells to DNA double strand breaks
... AP DNA binding activity (Kuhnlein ...of breaks, allowing DNA polymerisation to subsequently fill the ...of DNA in AT cells has been suggested to involve a deficient poly(ADP-ribose) polym ...
305
Capture of Extranuclear DNA at Fission Yeast Double-Strand Breaks
... of DNA double-strand breaks (DSBs) is necessary for the maintenance of genomic integ- ...mitochondrial DNA (mtDNA) at high ...at DSBs, supporting a role for the complex in ...
14
Ubiquitination by HUWE1 in tumorigenesis and beyond
... increased DNA methylation and reduced binding of the insulator protein CTCF at the ICR ...at DNA double-strand breaks (DSBs) ...Upon DSBs, H2AX is dissociated from HUWE1 ...
15
Drug repurposing screen identifies lestaurtinib amplifies the ability of the poly (ADP ribose) polymerase 1 inhibitor AG14361 to kill breast cancer associated gene 1 mutant and wild type breast cancer cells
... Both BRCA1 and BRCA2 play essential roles in many biological processes [12-17]. A common feature of BRCA1/ 2-associated tumorigenesis is massive genetic instability, primarily due to the fact that cells lacking BRCA1 or ...
14
A Role for the Twins Protein Phosphatase (PP2A-B55) in the Maintenance of Drosophila Genome Integrity
... the DNA damage response and ...in DNA double strand breaks (DSBs) and chromosome aberrations ...prevents DNA damage are still ...G2/M DNA damage checkpoint while ...
17
“Breaking news” from spermatids
... to DNA damage and DNA double-strand breaks (DSBs) are observed ...minated DNA adopts a completely different topology as the somatic-like DNA supercoiling is lost ...
5
Replication Protein A Is Required for Meiotic Recombination in Saccharomyces cerevisiae
... transient DNA double-stranded breaks (DSBs). These DSBs undergo a 5⬘ → 3⬘ resection to produce 3⬘ single-stranded DNA ends that serve to channel DSBs into the RAD52 ...
14
Predicting double strand DNA breaks using epigenome marks or DNA at kilobase resolution
... between DSBs and epigenomic and chromatin marks, we sought to build a classifier to dis- criminate DSB sites from non-DSB sites based on the presence or absence of such ...of DSBs based on the epige- nomic ...
14
ZFN-mediated gene targeting of the Arabidopsis protoporphyrinogen oxidase gene through Agrobacterium-mediated floral dip transformation.
... of double-strand breaks (DSBs) at the intended recombination site enhanced the frequency of gene targeting (GT) at an artificial target locus using Agrobacterium-mediated floral dip ...of ...
6
Capture of DNA Sequences at Double-Strand Breaks in Mammalian Chromosomes
... study double-strand break (DSB)-induced mutations in mammalian chromosomes, we transfected thymidine kinase (tk)-deficient mouse fibroblasts with a DNA substrate containing a recognition site for ...
10
Expansions and Contractions in 36-bp Minisatellites by Gene Conversion in Yeast
... then DNA polymerases can traverse the intervening re- tion (Buard and Vergnaud 1994; Jeffreys et ...of double- higher rate of both expansions and contractions of the strand breaks ...
12
Advances in using PARP inhibitors to treat cancer
... radiation-induced DNA damage in patients without known defects in DDR is either possible or ...of DNA damage by the addition of a PARP inhibitor to a topoisomerase I poison has been demonstrated in tumor ...
5
Regulation of DNA Double-Strand Break Repair by
... Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in. 780[r] ...
28