DNA mismatch repair
Accuracy of four mononucleotide repeat markers for the identification of DNA mismatch repair deficiency in solid tumors
... Microsatellite instability (MSI) is characterized by the accumulation of insertion-deletion mutations at microsatellite-repeat sequences and represents a hall- mark feature of cancer cells with DNA ...
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Maternal Effect for DNA Mismatch Repair in the Mouse
... DNA mismatch repair (DMR) functions to maintain genome stability. Prokaryotic and eukaryotic cells deficient in DMR show a microsatellite instability (MSI) phenotype characterized by repeat length ...
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Dual daughter strand incision is processive and increases the efficiency of DNA mismatch repair
... DNA mismatch repair (MMR) is crucial for the mainte- nance of genomic ...for mismatch recognition and endonucleolytic incision of the newly-synthesized DNA strand ...quently, DNA ...
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Saturation of DNA Mismatch Repair and Error Catastrophe by a Base Analogue in Escherichia coli
... for kanamycin resistance followed by testing for mutator phe- ties associated with the recA, umuDC, or uvrA genes. notype. The recA56 allele was introduced by P1 transduction However, the mutH, -L, -S DNA ...
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Role of DNA Mismatch Repair and Double-Strand Break Repair in Genome Stability and Antifungal Drug Resistance in Candida albicans
... in DNA mismatch repair (MMR) exhibit a mutator phenotype in which the rate of spontaneous mutation is greatly elevated (6, ...the DNA replication factor PCNA (5, ...repetitive DNA ...
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Dynamics of DNA Mismatch Repair Initiation Complexes Revealed by Single Molecule Fluorescence.
... the DNA mismatch repair protein MutS that control its roles in MMR ...The DNA binding domain I of MutS undergoes substantial conformational changes during mismatch recognition and ...
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Functional role of DNA mismatch repair gene PMS2 in prostate cancer cells
... DNA mismatch repair (MMR) enzymes act as proofreading complexes that maintains genomic integrity and MMR-deficient cells show an increased mutation ...
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PMS2 gene mutation results in DNA mismatch repair system failure in a case of adult granulosa cell tumor
... induces DNA mismatch repair system ...that DNA mismatch repair system failure induces FOXL2 402C > G mutation, leading to granulosa cell tumor development ...The DNA ...
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A Role for DNA Mismatch Repair Protein Msh2 in Error-Prone Double-Strand-Break Repair in Mammalian Chromosomes
... B DNA termini were ...of repair events recovered, all NHEJ junctions are considered, 16 of 49 junctions although we noted that one cell line, CB6, produced recovered from clone B cells displayed no terminal ...
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Escherichia coli mutator mutD5 is defective in the mutHLS pathway of DNA mismatch repair.
... Competent cells derived from the mutD5 strain are severely affected in their ability to perform mismatch repair, yielding a percentage of mixed bursts close to that of the mu[r] ...
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Ensemble and single-molecule fluorescence studies of DNA mismatch repair initiation by MutS
... (ie. DNA bound by ...as DNA bending), the net anisotropy would reflect those motions and be reduced (Lakowicz ...dynamic DNA bending in mismatched DNA bound by MutS would contribute to a ...
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DNA mismatch repair gene MSH6 implicated in determining age at natural menopause
... in DNA repair were identified in the recent GWAS for age at menopause, including EXO1, UIMC1, MCM8 and ...to DNA damage sites and initiates G2/M checkpoint control ...of DNA replication ...
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DNA Mismatch Repair Proteins Are Required for Efficient Herpes Simplex Virus 1 Replication
... To further test whether MLH1 is indeed an ND10 compo- nent, we chose to silence PML and monitor the localization of MLH1. PML is the central organizer of ND10, and many ND10 components become nuclear diffuse or have ...
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The Role of DNA Mismatch Repair and Recombination in the Processing of DNA Alkylating Damage in Living Yeast Cells
... the DNA alkylating agent (less than 1 per 100 cells, Figure 3(a) top left panel) and is increased at least 15-fold after treatment (Figure 3(a) top right panel and Figure ...for DNA damage in general ...
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Dynamic Emergence of Mismatch Repair Deficiency Facilitates Rapid Evolution of Ceftazidime Avibactam Resistance in Pseudomonas aeruginosa Acute Infection
... in DNA mismatch repair have been studied in the context of chronic infection, where elevated muta- tional rates (“hypermutation”) may facilitate the acquisition of antimicrobial resis- ...evolved ...
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Thyroid cancer in a patient with a germline MSH2 mutation. Case report and review of the Lynch syndrome expanding tumour spectrum
... Lynch syndrome (HNPCC) is a dominantly inherited disorder characterized by germline defects in DNA mismatch repair (MMR) genes and the development of a variety of cancers, predominantly colorectal ...
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A gene expression assay for simultaneous measurement of microsatellite instability and anti-tumor immune activity
... DNA mismatch repair deficiency (MMRd) has been observed in most cancer types in The Cancer Genome Atlas (TCGA), and occurs in more than 5% of adrenal, rectal, colon, stomach, and endometrial tumors ...
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Molecular pathogenesis in granulosa cell tumor is not only due to somatic FOXL2 mutation
... system failure appears likely in this patient. In such a case, early detection allows for treatment of benign tumor. Although this study could not elucidate the exact mechan- ism for the development of granulosa cell ...
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Requirement of Mismatch Repair Genes MSH2 and MSH3 in the RAD1-RAD10 Pathway of Mitotic Recombination in Saccharomyces cerevisiae
... The MSH2 and MSH3 genes participate in DNA mismatch repair; null mutations in these genes result in elevated rates of spontaneous mutations and in an increase in the [r] ...
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No Change in Frequency of Microsatellite Instability in Colorectal Cancers over a Period of 15 or More Years
... Microsatellite instability (MSI) is a molecular change resulting from inactiva- tion of DNA mismatch repair systems, occurring with a reported incidence between 15% - 20% of all sporadic colorectal ...
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