DNA sensing
Conservation of the STING-Mediated Cytosolic DNA Sensing Pathway in Zebrafish
... Zebrafish (Danio rerio) is a unique potential model animal for dissecting innate immune signaling. Here we demonstrate that herpes simplex virus 1 (HSV-1) could infect zebrafish at its different developmental stages and ...
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Non canonical activation of the DNA sensing adaptor STING by ATM and IFI16 mediates NF κB signalling after nuclear DNA damage
... the DNA damage kinase ataxia telangiectasia mutated (ATM) and the enzyme poly(ADP-ribose) polymerase 1 (PARP-1) (Hinz et ...the DNA sensing factors IFI16 and STING, but is independent of cGAS and ...
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Adenovirus Detection by the cGAS/STING/TBK1 DNA Sensing Cascade
... viral DNA can trigger the TLR9 pathway, which through the MyD88 adaptor leads to activation of IRF7 and IRF5 but not ...viral DNA complexes to the cytosolic compartment. An array of DNA sensors are ...
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Virulent Poxviruses Inhibit DNA Sensing by Preventing STING Activation
... viral DNA with DNA-binding proteins, targeting cGAS, or enzymatically degrading ...of DNA sensing during poxvirus infection provides a unique model that offers a better mech- anistic ...
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Evasion of the STING DNA-Sensing Pathway by VP11/12 of Herpes Simplex Virus 1
... ABSTRACT The stimulator of interferon (IFN) genes (STING) is a broad antimicrobial factor that restricts herpes simplex virus (HSV) by activating type I interferon and proinflammatory responses upon sensing of ...
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Herpes Simplex Virus 1 Ubiquitin-Specific Protease UL36 Abrogates NF-κB Activation in DNA Sensing Signal Pathway
... cGAS-dependent DNA sensing pathway by directly binding to DNA and cGAS and inhibiting cGAS enzymatic activity ...the DNA sensing signal pathway by abrogating the interaction between ...
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DNA Sensing-Independent Inhibition of Herpes Simplex Virus 1 Replication by DAI/ZBP1
... DAI is not essential for IFN-  transcription through cytoso- lic B-DNA sensing in HepG2 cells. We investigated whether DAI plays an essential role in the type I IFN pathway in HepG2 cells after treatment ...
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Restriction of Human Cytomegalovirus Replication by ISG15, a Host Effector Regulated by cGAS-STING Double-Stranded-DNA Sensing
... this DNA-sensing-induced ISG15 modification might impact experimental outcomes and the functionality of proteins expressed from transfected DNA in uninfected cells needs to be ...understanding ...
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Non canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF κB Signaling after Nuclear DNA Damage
... the DNA damage kinase ataxia telangiectasia mutated (ATM) and the enzyme poly(ADP-ribose) polymerase 1 (PARP-1) (Hinz et ...the DNA sensing factors IFI16 and STING, but is independent of cGAS and ...
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Herpes Simplex Virus 1 Serine Protease VP24 Blocks the DNA-Sensing Signal Pathway by Abrogating Activation of Interferon Regulatory Factor 3
... cytosolic DNA-sensing receptors has been identified: cyclic GMP-AMP synthase (cGAS), IFN-␥-inducible protein 16 (IFI16), DEAD box polypeptide 41 (DDX41), DNA-dependent activator of IFN regu- latory ...
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Herpes Simplex Virus 1 UL24 Abrogates the DNA Sensing Signal Pathway by Inhibiting NF-κB Activation
... double-stranded DNA (dsDNA) and utilizes the IKK ␣ /  activation loop to activate the NF- B subunit p65 in response to STING ...viral DNA that leaks into the cytosol can be sensed by cGAS, which ...
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Atom Transfer Radical Polymerization (ATRP)in Amplification-by-Polymerization for DNA Sensing
... the DNA-anchored substrate was clearly observed in 2hr, qualitatively suggesting more efficient polymer growth at the presence of DNA ...the DNA-anchored surface beyond 2hr was probably the result of ...
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Collateral Damage during Dengue Virus Infection: Making Sense of DNA by cGAS
... this DNA sensor during infections with RNA viruses remained a ...that DNA sensing by cGAS is not sequence specific ...cellular DNA in the cytoplasm of DENV-infected cells ...for DNA ...
5
Herpes Simplex Virus 1 Tegument Protein VP22 Abrogates cGAS/STING-Mediated Antiviral Innate Immunity
... VP22, encoded by the UL49 gene, is a highly abundant tegument protein in HSV-1, and its amino acid sequence is conserved in the subfamily Alphaherpesvirinae. In infected cells, VP22 is phosphorylated, possibly by CKII ...
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PubMedCentral-PMC4755325.pdf
... cytosolic DNA-induced IFNβ ...cytosolic DNA sensing pathway (Ishikawa et al., 2009). There are many DNA sensors that have been identified to ...the DNA sensors, DNA-dependent ...
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An examination of the role of IFI16 in detecting viral DNA in human immortalised keratinocytes
... cytosolic DNA to be identified (Takaoka et ...with DNA upon transfection and associated with TBK1 and IRF3 to induce IFNβ ...for DNA sensing as these mice and cell lines lacking DAI displayed ...
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Viral DNA-Dependent Induction of Innate Immune Response to Hepatitis B Virus in Immortalized Mouse Hepatocytes
... DNA sensing can also trigger an inflammatory response and cell death (11, 15, ...HBV DNA itself is a major trigger of inflammatory diseases, possibly via triggering of the host DNA- ...
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A Rapid, Label-free and Impedimetric DNA Sensor Based on PNA-modified Nanoporous Gold Electrode
... for DNA sensing [11]. PNA probe possesses two main advantages over DNA probe for hybridization: firstly, no electrostatic repulsion between PNA and negatively charged DNA, which make PNA can ...
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Serum cytokine profiling analysis for zheng differentiation in chronic hepatitis B
... cytosolic DNA‑sensing pathway, and chemokine signaling pathway overlapped between LGDH and LKYD, whereas Toll‑like receptor signaling pathway, intestinal immune network for IgA production, NOD‑like receptor ...
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The cell intrinsic innate immune response to DNA damage in human cells
... their DNA as early as 4 hours after the damage ...of DNA can be seen to leave the nucleus, and cluster with cytoplasmic components of the DNA sensing ...to DNA damage (Huang, ...nuclear ...
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