Drug Repurposing
ACID: a free tool for drug repurposing using consensus inverse docking strategy
... To evaluate the usage of the ACID web server, two examples are presented here. First, we show a test case using Citalopram as the query structure to find its poten‑ tial target proteins via ACID server. Table S3 gives ...
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Identifying Protein Features Responsible for Improved Drug Repurposing Accuracies Using The CANDO Platform: Implications for Drug Design
... Abstract: Drug repurposing is a valuable tool for combating the slowing rates of novel therapeutic ...Novel Drug Opportunities (CANDO) platform performs shotgun repurposing of 2,030 ...
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Data Science in Unveiling COVID-19 Pathogenesis and Diagnosis: Evolutionary Origin to Drug Repurposing
... The potential applications for data-science (and deep-learning and arti- ficial intelligence) to improve the research related to SARS-COV-2 outbreak are countless. However, due to the tremendous spread of the virus and ...
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Drug repurposing identified the combination of Trolox C and Cytisine for the treatment of type 2 diabetes
... the drug- repurposing, for example, the importance of ...of drug combination by consider- ing the above ...for drug-repurposing and would greatly extend the space of ...
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K-Map: connecting kinases with therapeutics for drug repurposing and development
... Protein kinases play important roles in regulating signal transduction in eukaryotic cells. Due to evolutionary conserved binding sites in the catalytic domain of the kinases, most inhibitors that target these sites ...
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Drug repurposing in malignant pleural mesothelioma: a breath of fresh air?
... of drug repurposing is to identify and develop new indications for approved drugs [1, ...oncology, drug repositioning consists of demonstrating the anticancer properties of marketed drugs approved ...
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Support for phosphoinositol 3 kinase and mTOR inhibitors as treatment for lupus using in silico drug repurposing analysis
... In this context, Lincscloud [8] has been deployed re- cently as the successor to the Connectivity Map. This database contains genetic profiles derived from a larger number of drugs and also includes knock-down and ...
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Drug repurposing : a systematic approach to evaluate candidate oral neuroprotective interventions for secondary progressive multiple sclerosis
... It is therefore possible that we have failed to identify many drugs for which there is good evi- dence, from various sources, to suggest that they might have efficacy in SPMS. Whether our method to select candidate ...
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Large-scale detection of drug off-targets: hypotheses for drug repurposing and understanding side-effects
... of drug repurposing and deter- mine molecular mechanisms responsible for side ...effects. Drug off-targets were identified in a number of different ways using other binding-site similarity methods ...
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Deciphering miRNA transcription factor feed-forward loops to identify drug repurposing candidates for cystic fibrosis
... on repurposing candidates from the miRNA-small molecule perspective while the relationship between TFs and small molecules, that is, drugs affecting transcription factor expression and activ- ity was not ...
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Network Bioinformatics Analysis Provides Insight into Drug Repurposing for COVID-2019
... novel drug discovery and vaccine studies are long, repurposing old drugs against the COVID-2019 epidemic can help identify treatments, with known preclinical, pharmacokinetic, pharmacodynamic, and toxicity ...
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Drug Repurposing in Antiviral Research: A Current Scenario
... Combining drug–target network analysis and functional validation will help in identifying new genes and pathways to develop new antiviral drug molecules for ZIKV ...high-throughput, ...
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COMPUTATIONAL DRUG REPURPOSING FOR BREAST CANCER SUBTYPES
... In this thesis, we aimed to find suitable drug repurposing candidates for each of the ten breast cancer subtypes. We were given METABRIC and LINCS datasets. We performed a series of preprocessing steps on ...
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SILICO MODELING AND DOCKING OF Cch1 PROTEIN OF CANDIDA GLABRATA WITH FDA APPROVED DRUGS: A DRUG REPURPOSING APPROACH
... Considering the increase in the resistance to existing drugs and epidemiology shift from albicans to non-albicans Candida, it has become essential to explore new drugs against Candida pathogens, especially C. glabrata. ...
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Drug repurposing for the treatment of glioblastoma multiforme
... that drug repositioning, finding new uses for existing drugs, or drug repurposing, a re-use of old drugs when novel molecular findings make them attract- ive again, are gaining importance in clinical ...
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Identification of drug repurposing candidates based on a miRNA-mediated drug and pathway network for cardiac hypertrophy and acute myocardial infarction
... = 0.917) that was close to that of the majority of biological networks (Fig. 1c). In addition, this result suggested that this MGDT network was similar to a small-world network [18]. Moreover, we found that the degree ...
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Drug Repurposing Screening Identifies Novel Compounds That Effectively Inhibit Toxoplasma gondii Growth
... of drug repurposing screens is that pharmacokinetic and pharma- codynamic parameters are established for each compound and their putative target(s) is also known (51, ...that drug repurposing ...
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Cancer based pharmacogenomics network supported with scientific evidences: from the view of drug repurposing
... Idiosyncratic information without semantic interoperability and standard-based anno- tation, however, adds no value to the scientific commons. These idiosyncratic data must be annotated using standard terms and elements ...
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Systems pharmacology–based integration of human and mouse data for drug repurposing to treat thoracic aneurysms
... consider drug targets as nodes within cellular regulatory networks can use differentially expressed genes (DEGs) to predict dysregulated SCPs that underlie cell-level mechanisms (1, ...
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Drug repurposing screen identifies Foxo1-dependent angiopoietin-2 regulation in sepsis
... and Drug Administration–approved compounds, we identified multiple members of the 3-hydroxy-3- methyl-glutaryl-CoA reductase inhibitor drug class (referred to as statins) that suppressed ...
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