Dual-Specificity Phosphatase
Suppression of dual specificity phosphatase–2 by hypoxia increases chemoresistance and malignancy in human cancer cells
... MAPK-specific phosphatase dual-specificity phosphatase–2 (DUSP2) is markedly reduced or com- pletely absent in many human cancers and that its level of expression inversely correlates with ...
13
Molecular alterations and tumor suppressive function of the DUSP22 (Dual Specificity Phosphatase 22) gene in peripheral T-cell lymphoma subtypes
... (Dual Specificity Phosphatase 22) gene silencing have been reported in CD30+ peripheral T-cell lymphomas (PTCL), mostly with anaplastic morphology and of cutaneous ...
15
Human Dual Specificity Phosphatase hYVH1: Structural Insights and Functions in Stress Granule Dynamics
... the dual specificity phosphatase (DUSP) sub-families ...the specificity and reaction rate of labeling reagents used for modification, enrichment and ...
239
Original Article High expression of dual-specificity phosphatase 5 pseudogene 1 (DUSP5P1) is associated with poor prognosis in acute myeloid leukemia
... Abstract: The purpose of this study was to investigate the expression status of Dual-Specificity Phosphatase 5 Pseudogene 1 (DUSP5P1) and its clinical relevance in patients with acute myeloid ...
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Functional cdc25C dual-specificity phosphatase is required for S-phase entry in human cells
... Human Cdc25C subcloned into the T7-inducible bacterial expres- sion vector pRK171 was a kind gift of Paul Russell (Scripps Research Institute, La Jolla, CA). Recombinant cdc25C was expressed using BL21 (DE3) bacteria ...
15
The dual-specificity phosphatase encoded by vaccinia virus, VH1, is essential for viral transcription in vivo and in vitro.
... the phosphatase deficiency affected transcription per se or some step prerequisite for its onset in vivo, the ability of wt, H1 1 , and H1 2 virions to direct transcription in vitro was ...the phosphatase ...
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Structure-Function Characterization of the Human Dual Specificity Phosphatase hYVH1
... It has been previously shown that hYVH1 is unable to dephosphorylate artificial substrates such as pNPP. Because pNPP has a higher pKa than that of DiFMUP, it is more dependent on the catalytic acid step for efficient ...
150
Interleukin-1 loop model for pathogenesis of Langerhans cell histiocytosis
... receptor-associated kinase 1, is expressed at a significantly higher level in LCH affecting multiple organ systems (MS-LCH) than in LCH affecting a single organ system (SS-LCH). IL-1 stimulates T helper 17 cells and ...
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Functional Regulation of Dual Specificity Phosphatases: Modifications, Methods for Analysis, and Mass Spectrometry
... protein phosphatase superfamily is partitioned into two main sub-familes known as the protein Ser/Thr phosphatases (PS/TPs) and the protein tyrosine phosphatases (PTPs), not only on the basis of substrate ...
274
<em>DUSP4</em>/MKP2 overexpression is associated with BRAF<sup>V600E</sup> mutation and aggressive behavior of papillary thyroid cancer
... Abstract: The study was performed to retrospectively analyze the correlation of dual specificity phosphatase 4 (DUSP4) expression with clinicopathological variables and BRAF V600E mut[r] ...
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MAP kinase phosphatases
... 16 dual specificity and low- molecular-weight phosphatases and five phosphatase-like STYX ...yeast dual specificity phosphatase gene MSG5 in the regulation of the MAP kinase Fus3 ...
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Merkel cell polyomavirus and Langerhans cell neoplasm
... DC: Dendritic cell; DUSP6: Dual specificity phosphatase 6; ELISA: Enzyme- linked immunosorbent assay; ERK: Extracellular signal-regulated kinase; ITIH4: Interalpha-trypsin inhibitor heav[r] ...
12
Long noncoding RNA CCDC144NL-AS1 knockdown induces naïve-like state conversion of human pluripotent stem cells
... DUSP: Dual-specificity phosphatase; EBs: Embryoid bodies; EpiSCs: Post-implantation epiblast- derived stem cells; FGF2: Fibroblast growth factor 2; FGFR: Fibroblast growth factor receptor; FPKM: ...
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Elevated dual specificity protein phosphatase 4 in cardiomyopathy caused by lamin A/C gene mutation is primarily ERK1/2-dependent and its depletion improves cardiac function and survival
... kinase phosphatase (MKP)-1 and MKP-2 in macrophages following lipopolysaccharide stimulation: the role of the C termini of the phosphatases in determining their ...
59
Characterization of the catalytic properties of dual specificity protein tyrosine phosphatase hYVH1.
... The tertiary structure of the catalytic domain is rich in beta sheets with helices surrounding the PTP signature motif C(X5)R. Although, this signature motif has been found to be located at varied positions within ...
96
Antigenic and genetic analyses of human rotavirus with dual subgroup specificity
... The reactivity pattern of these four HRV isolates with three monoclonal antibodies MAbs directed to an outer capsid protein, VP4, and with one MAb directed to an inner capsid protein, VP[r] ...
5
Constructive Principle of Religious Style: Ontological Basisa
... Religious consciousness is radically different from other forms of social consciousness by the specificity of functional realization. The following functions of religion are significant from a philosophical point ...
5
Over-expression of MAP kinase phosphatase-2 enhances adhesion molecule expression and protects against apoptosis in human endothelial cells
... a dual specific nuclear phosphatase, MKP-2, as an experimental pharmacological tool to reverse JNK mediated responses in HUVECs and thus determine its potential use in clinical conditions involving ...
34
Emerging Regulatory Roles of Dual-Specificity Phosphatases in Inflammatory Airway Disease.
... Much of the literature regarding DUSPs in innate immunity have focused on bacterial infection, and few studies have examined their roles in viral infection. DUSP1 (MKP1) is the archetype of the family and the most well ...
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Platelet Activating Factor Induces Du al Specificity Phosphatase 1 and 5 Gene Expression
... Since dual-specificity phosphatases (DUSP) downregulated MAPK activity, we postulated that PAF could also enhance DUSP expression and thus induced an autoregulatory ...
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