dual specificity protein phosphatase
Elevated dual specificity protein phosphatase 4 in cardiomyopathy caused by lamin A/C gene mutation is primarily ERK1/2-dependent and its depletion improves cardiac function and survival
... localization. Confocal micrographs showed that phospho-ERK1/2 were localized to the nuclear rim in cells expressing H222P lamin A to a greater degree than in those expressing the WT protein (Fig. 5C). Linear ...
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Long noncoding RNA CCDC144NL-AS1 knockdown induces naïve-like state conversion of human pluripotent stem cells
... DUSP: Dual-specificity phosphatase; EBs: Embryoid bodies; EpiSCs: Post-implantation epiblast- derived stem cells; FGF2: Fibroblast growth factor 2; FGFR: Fibroblast growth factor receptor; FPKM: ...
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Functional cdc25C dual-specificity phosphatase is required for S-phase entry in human cells
... be present in G1 for the cell to commit to S-phase (Hinch- cliffe et al., 2001). Therefore the lack of cdc25C could be detected by a sensor mechanism, such as the S-phase check- point. Our results also show that ...
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PROTEIN PHOSPHATASES-OCCURRENCE, CLASSIFICATION AND AS DRUG TARGETS IN HUMAN DISEASES
... of protein tyrosine phosphatase (PTPase) and protein serine/threonine phosphatase (PSThPase) families, giving rise to major advances in mechanistic understanding ...activated protein ...
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MAP kinase phosphatases
... predicted protein tyrosine kinases, it has 16 dual specificity and low- molecular-weight phosphatases and five phosphatase-like STYX ...yeast dual specificity phosphatase ...
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Suppression of dual specificity phosphatase–2 by hypoxia increases chemoresistance and malignancy in human cancer cells
... HIF-1α protein is elevated in most solid tumors and contributes to poor disease outcome by pro- moting tumor progression, metastasis, and resistance to ...MAPK-specific phosphatase ...
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Structure-Function Characterization of the Human Dual Specificity Phosphatase hYVH1
... vitro phosphatase assays are useful tools that can lend insight into the function or regulation of protein phosphatases, and assess the consequence of effector molecules and protein modifications on ...
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Characterization of the catalytic properties of dual specificity protein tyrosine phosphatase hYVH1.
... a protein kinase to the hydroxyl side chain of, serine, thereonine and tyrosine residues in eukaryotes, or histidine and aspartate residues in prokaryotes ...the protein by a protein ...
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The dual-specificity phosphatase encoded by vaccinia virus, VH1, is essential for viral transcription in vivo and in vitro.
... H1 protein encapsidated within H1 2 virions is correlated with the decreased fraction of par- ticles which are ...and protein profiles were formed (data not ...
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Molecular alterations and tumor suppressive function of the DUSP22 (Dual Specificity Phosphatase 22) gene in peripheral T-cell lymphoma subtypes
... To generate expression vectors, the coding sequences of DUSP22 isoforms were amplified by polymerase chain reaction (PCR) using complementary DNA (cDNA) from normal lymphocytes as a template. The following primers were ...
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Original Article High expression of dual-specificity phosphatase 5 pseudogene 1 (DUSP5P1) is associated with poor prognosis in acute myeloid leukemia
... Pseudogenes are sequences typically charac- terized by close similarities to one or more paralogous genes, yet lost the ability to pro- duce functional protein mostly due to mutation or aberrant duplication [22, ...
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Mitogen activated protein kinase phosphatase 1 in rat arterial smooth muscle cell proliferation
... Smooth muscle cell proliferation and migration is impor- tant in arteriosclerosis. In this process, cytokines and growth factors are upregulated and bind to their respective receptors, which in turn stimulate ...
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Tyrosine Phosphorylation of A17 during Vaccinia Virus Infection: Involvement of the H1 Phosphatase and the F10 Kinase
... a dual-spec- ificity protein ...of dual specificity kinases is often highly substrate specific, and an unbiased scan of all bacterial proteins has frequently been more profitable than ...
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Role and regulation of MKP-1 in airway inflammation
... served protein tyrosine phosphatase (PTP) catalytic site [34, 35, 42, ...name dual specificity phosphatases ...inducing protein stabilization ...
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Human Dual Specificity Phosphatase hYVH1: Structural Insights and Functions in Stress Granule Dynamics
... examining protein thiol redox status rely heavily on differential labeling, whereby reversibly oxidized protein or peptide thiols are labeled with some 'reporter tag(s)' for subsequent identification using ...
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Serine/Threonine Protein Phosphatase Mediated Control of the Peptidoglycan Cross Linking l,d Transpeptidase Pathway in Enterococcus faecium
... serine/threonine protein kinase (IreK) was identified as essential for ceftriaxone resistance in ...associated protein phosphatase, IreP, showed that the phosphorylation of one or several IreK sub- ...
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Catalytic Subunit 1 of Protein Phosphatase 2A Is a Subunit of the STRIPAK Complex and Governs Fungal Sexual Development
... scaffold protein PRO40 of the CWI ...both protein complexes. In detail, we confirmed putative protein-protein interactions between PRO22 and MAK1 and between PRO40 and PP2AA ...
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AR-v7 protein expression is regulated by protein kinase and phosphatase
... with protein components that are associated with AR and PI3K/Akt signaling ...and protein expression is differentially ...AR-v7 protein expression, as well as genetic alterations associated with PP-1 ...
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Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase 1 in Tat activated HIV 1 transcription
... phosphatases, protein phosphatase 2A (PP2A) and protein phosphates-1 (PP1) were implicated in the regulation of HIV-1 ...of protein phosphatases with predomi- nant nuclear localization ...the ...
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Skeletal muscle protein tyrosine phosphatase activity and tyrosine phosphatase 1B protein content are associated with insulin action and resistance
... cytosolic protein tyrosine phosphatase (PTPase) activity was measured in skeletal muscle from 15 insulin-sensitive subjects and 5 insulin-resistant nondiabetic subjects, as well as 18 subjects with ...
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