Duffy binding protein
Human vaccination against Plasmodium vivax Duffy-binding protein induces strain-transcending antibodies
... vivax Duffy-binding protein (PvDBP) with the human Duffy antigen receptor for chemokines (DARC/Fy) ...Notably, Duffy-negative individuals are protected from blood-stage ...of ...
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The Duffy binding protein (PkDBPαII) of Plasmodium knowlesi from Peninsular Malaysia and Malaysian Borneo show different binding activity level to human erythrocytes
... the Duffy antigen receptor for chemokines (DARC) to invade Duffy-positive human ...erythrocytes. Duffy-negative human erythrocytes are refractory to invasion by these two Plasmodium spe- cies ...the ...
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Immunogenicity of a Synthetic Vaccine Based on Plasmodium vivax Duffy Binding Protein Region II
... merozoite Duffy binding protein (DBP) and its cognate recep- tor, the Duffy antigen receptor for chemokines (DARC), on the re- ticulocyte ...DBP-erythrocyte binding, as well as inhibit ...
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Possible Mimics of Duffy Binding Protein-II for Plasmodium vivax Binding Endothelial Cells or Binding Plasmodium falciparum by Mimicking Epitope on Erythrocyte Binding Antigen-175 A
... of Duffy Binding Protein II (DBPII) monomers 1 and 2 from ...2 binding there would be half the Duffy Antigen Receptor for Chemokines (DARC) binding to the DBPII ...potential ...
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Distinct genetic difference between the Duffy binding protein (PkDBPαII) of Plasmodium knowlesi clinical isolates from North Borneo and Peninsular Malaysia
... Background: Plasmodium knowlesi is one of the monkey malaria parasites that can cause human malaria. The Duffy binding protein of P. knowlesi (PkDBP α II) is essential for the parasite ’ s invasion ...
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Erythrocyte binding assays reveal higher binding of Plasmodium knowlesi Duffy binding protein to human Fya+/b+ erythrocytes than to Fya+/b erythrocytes
... the binding level was quantita- tively determined by counting the number of rosettes in the erythrocyte binding assay, and the difference in the mean number of rosettes obtained in the assays for Fy a+/b+ ...
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Identification of an Immunogenic Broadly Inhibitory Surface Epitope of the Plasmodium vivax Duffy Binding Protein Ligand Domain
... vivax Duffy binding protein (DBP) binds its cognate receptor, the Duffy antigen receptor for chemokines (DARC), on reticulocytes to form an irreversible junction critical for merozoite ...
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Genetic diversity, natural selection and haplotype grouping of Plasmodium vivax Duffy binding protein genes from eastern and western Myanmar borders
... the Duffy-binding protein (PvDBP), a microneme protein, and the Duffy antigen receptor for chemokines (DARC) on the RBC membrane [11, ...vivax binding to reticulocytes have been ...
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Diversity pattern of Duffy binding protein sequence among Duffy negatives and Duffy positives in Sudan
... of Duffy‑neg‑ ative blood group population, Plasmodium vivax in Africa historically is less attributable and remains a neglected dis‑ ...between Duffy binding protein and its cognate receptor, ...
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Genetic diversity, haplotypes and allele groups of Duffy binding protein (PkDBPαII) of Plasmodium knowlesi clinical isolates from Peninsular Malaysia
... The DBP of P. vivax and P. knowlesi play an essential role in erythrocyte invasion of the parasites by mediating irreversible binding with its corresponding receptor, the Duffy protein receptor for ...
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Genetic variability and natural selection at the ligand domain of the Duffy binding protein in brazilian Plasmodium vivax populations
... recombination prevents the reliable reconstruction of a phylogeny. This analysis, which estimates ω and its asso- ciated HPD interval, also revealed that natural selection does not act uniformly within the gene (Figure ...
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Design and Immunogenicity of a Novel Synthetic Antigen Based on the Ligand Domain of the Plasmodium vivax Duffy Binding Protein
... the Duffy binding-like erythrocyte binding protein (DBL-EBP) family from the erythrocyte-binding- like (ebl) genes, sequestered in the micronemes and released to the merozoite surface ...
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Sequence similarity between the erythrocyte binding domain 1 of the Plasmodium vivax Duffy binding protein and the V3 loop of HIV 1 strain MN reveals binding residues for the Duffy Antigen Receptor for Chemokines
... gD protein [7] Duffy Fy (a-b+) erythrocytes were washed three times in RPMI 1640, resuspended to a hematocrit of 1% in 1 ml of complete DMEM with the chemokines RANTES, MIP-1a, SDF-1 or AOP-RANTES at ...
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Polymorphism patterns in Duffy binding protein among Thai Plasmodium vivax isolates
... The PCR amplification of the P. vivax DBPII gene from 30 Thai isolates yielded DNA fragments of approximately 990 base pairs in length (Figure 1). A 900 bp was selected after excluding primer regions and adjacent bases ...
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Sequence similarity between the erythrocyte binding domain of the Plasmodium vivax Duffy binding protein and the V3 loop of HIV 1 strain MN reveals a functional heparin binding motif involved in binding to the Duffy antigen receptor for chemokines
... [21]. Duffy Fy (a-b+) erythrocytes were washed three times in RPMI 1640, resuspended to a hematocrit of 1% in 1 ml of complete DMEM with polyanions at concentrations of 0, 1, 10, 100, and 1000 μ ...of ...
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Single-Chain Antibody Fragment Specific for Plasmodium vivax Duffy Binding Protein
... surface protein 1, reticulocyte binding protein, and DBP, which have high binding affinity to erythrocytes (9, 10, 14, ...high binding affinity and its strong antigenicity in humans ...
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Easy and fast method for expression and native extraction of Plasmodium vivax Duffy binding protein fragments
... parasite protein interactions with their target cells (reticulocytes) has been studied with molecules obtained from eukaryote ...regarding protein–cell interaction techniques was thus standard- ized here; ...
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Genetic polymorphism and natural selection of Duffy binding protein of Plasmodium vivax Myanmar isolates
... Although polymorphic residues were widely distributed throughout the PvDBPII sequence, polymorphisms at resi- dues 417, 437, and 503, either in single or in combination, can affect the efficacy of inhibitory antibodies ...
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Recent increase of genetic diversity in Plasmodium vivax population in the Republic of Korea
... as Duffy-binding protein [28], PvCSP [9], PvMSP-3a [11], and AMA-1 [29] infers only two alleles whereas genetic diversity of these antigens remarkably increased after 2001 ...
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Genetic diversity and population structure of genes encoding vaccine candidate antigens of Plasmodium vivax
... sporozoite protein (CSP), Thrombospondin related anonymous protein (TRAP), Duffy-binding protein (DBP), Merozoite surface protein-1 (MSP-1) and Apical membrane antigen-1 (AMA-1) ...
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