Duffy binding protein (DBP)
Identification of an Immunogenic Broadly Inhibitory Surface Epitope of the Plasmodium vivax Duffy Binding Protein Ligand Domain
... vivax Duffy binding protein region II (DBPII) is a vital li- gand for the parasite’s invasion of reticulocytes, thereby making this molecule an at- tractive vaccine candidate against vivax ...
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Diversity pattern of Duffy binding protein sequence among Duffy negatives and Duffy positives in Sudan
... of Duffy‑neg‑ ative blood group population, Plasmodium vivax in Africa historically is less attributable and remains a neglected dis‑ ...between Duffy binding protein and its cognate receptor, ...
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Possible Mimics of Duffy Binding Protein-II for Plasmodium vivax Binding Endothelial Cells or Binding Plasmodium falciparum by Mimicking Epitope on Erythrocyte Binding Antigen-175 A
... of Duffy Binding Protein II (DBPII) monomers 1 and 2 from ...2 binding there would be half the Duffy Antigen Receptor for Chemokines (DARC) binding to the DBPII ...potential ...
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Distinct genetic difference between the Duffy binding protein (PkDBPαII) of Plasmodium knowlesi clinical isolates from North Borneo and Peninsular Malaysia
... Background: Plasmodium knowlesi is one of the monkey malaria parasites that can cause human malaria. The Duffy binding protein of P. knowlesi (PkDBP α II) is essential for the parasite ’ s invasion ...
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Erythrocyte binding assays reveal higher binding of Plasmodium knowlesi Duffy binding protein to human Fya+/b+ erythrocytes than to Fya+/b erythrocytes
... merozoite’s binding protein and its corresponding receptor on the surface of the ...its Duffy binding protein (PkDBP) and the erythrocyte’s Duffy antigen receptor for chemokines ...
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The Duffy binding protein (PkDBPαII) of Plasmodium knowlesi from Peninsular Malaysia and Malaysian Borneo show different binding activity level to human erythrocytes
... the Duffy antigen receptor for chemokines (DARC) to invade Duffy-positive human ...erythrocytes. Duffy-negative human erythrocytes are refractory to invasion by these two Plasmodium spe- cies ...the ...
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Human vaccination against Plasmodium vivax Duffy-binding protein induces strain-transcending antibodies
... vivax Duffy-binding protein (PvDBP) with the human Duffy antigen receptor for chemokines (DARC/Fy) ...Notably, Duffy-negative individuals are protected from blood-stage ...of ...
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Immunogenicity of a Synthetic Vaccine Based on Plasmodium vivax Duffy Binding Protein Region II
... lowered DBP immunogenicity, but im- portantly, inhibitory anti-DBPII antibodies were elicited against conserved neutralizing epitopes on the native Sal1 strain, which was used as the template and shared with other ...
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Single-Chain Antibody Fragment Specific for Plasmodium vivax Duffy Binding Protein
... surface protein 1, reticulocyte binding protein, and DBP, which have high binding affinity to erythrocytes (9, 10, 14, ...malaria, DBP is con- sidered an important vaccine ...
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Polymorphism patterns in Duffy binding protein among Thai Plasmodium vivax isolates
... Evidence of positive natural selection was determined by comparing the rate of nonsynonymous and synonymous substitutions in region II of the P. vivax DBP gene. The rates of substitutions were estimated using the ...
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Sequence similarity between the erythrocyte binding domain 1 of the Plasmodium vivax Duffy binding protein and the V3 loop of HIV 1 strain MN reveals binding residues for the Duffy Antigen Receptor for Chemokines
... the DBP of P. vivax on the cell surface as a chimera with the HSV gD protein [7] Duffy Fy (a-b+) erythrocytes were washed three times in RPMI 1640, resuspended to a hematocrit of 1% in 1 ml of ...
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Sequence similarity between the erythrocyte binding domain of the Plasmodium vivax Duffy binding protein and the V3 loop of HIV 1 strain MN reveals a functional heparin binding motif involved in binding to the Duffy antigen receptor for chemokines
... the DBP and V3 loops and mimic one or both binding properties of chemo- kines; to glycosaminoglycans (GAGs) or to sulfated tyro- sines on chemokine ...but DBP requires sulfation of tyrosine (Tyr 41) ...
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Genetic diversity, haplotypes and allele groups of Duffy binding protein (PkDBPαII) of Plasmodium knowlesi clinical isolates from Peninsular Malaysia
... The DBP of ...irreversible binding with its corresponding receptor, the Duffy protein receptor for chemokines (DARC) on the surface of erythrocytes ...The DBP elicits strong im- mune ...
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Genetic polymorphism and natural selection of Duffy binding protein of Plasmodium vivax Myanmar isolates
... Although polymorphic residues were widely distributed throughout the PvDBPII sequence, polymorphisms at resi- dues 417, 437, and 503, either in single or in combination, can affect the efficacy of inhibitory antibodies ...
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Design and Immunogenicity of a Novel Synthetic Antigen Based on the Ligand Domain of the Plasmodium vivax Duffy Binding Protein
... The DBP is a member of the Duffy binding-like erythrocyte binding protein (DBL-EBP) family from the erythrocyte-binding- like (ebl) genes, sequestered in the micronemes and ...
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Genetic variability and natural selection at the ligand domain of the Duffy binding protein in brazilian Plasmodium vivax populations
... the Duffy antigen/receptor for chemokines (DARC) on the surface of erythrocytes ...membrane protein called Duffy bind- ing protein (DBP), or PvDBP in ...a DBP gene-deletion ...
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Diversity and evolutionary genetics of the three major Plasmodium vivax merozoite genes participating in reticulocyte invasion in southern Mexico
... surface protein 1 (MSP1) participates in the initial adhesion to the reticulocyte and the apical membrane antigen 1 (AMA1) into parasite reorientation ...the Duffy binding protein (DBP) ...
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Genetic diversity and population structure of genes encoding vaccine candidate antigens of Plasmodium vivax
... sporozoite protein (CSP), Thrombospondin related anonymous protein (TRAP), Duffy-binding protein (DBP), Merozoite surface protein-1 (MSP-1) and Apical membrane antigen-1 ...
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A Novel Erythrocyte Binding Protein of Plasmodium vivax Suggests an Alternate Invasion Pathway into Duffy Positive Reticulocytes
... the Duffy blood group antigen (Fy), also known as the Duffy antigen receptor for chemokines (DARC) (3, ...vivax Duffy binding protein (DBP) on the merozoite interacts with DARC ...
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Easy and fast method for expression and native extraction of Plasmodium vivax Duffy binding protein fragments
... Valencia, CA, USA) pre-equilibrated with NEB or DEB for purification by solid-phase affinity chromatography. The resin-protein mixture was then poured onto a chro- matography column and washed with 20 mL buffer ...
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