Effector function
NKG2A inhibits TH2 cell effector function in vitro
... We induced NKG2A signaling using a monoclonal anti- body specific for the NKG2A receptor that has been shown to be an agonist and cause suppression of NK cell cytotoxicity in P815 target cells[27]. We used a magnetic ...
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New insights into Blimp-1 in T lymphocytes: a divergent regulator of cell destiny and effector function
... in effector regulatory T (Treg) cells ...in effector CD4 + T cells for the main- tenance of T cell homeostasis ...short-lived effector cells (SLECs), KLRG1 lo IL-7R hi memory precur- sor ...
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Enhanced effector function of cytotoxic cells in the induced sputum of COPD patients
... As well as showing an increased number of CD8 + T lymphocytes, NK cells and NKT-like cells, we have also shown that a significantly higher proportion of all these cell types express both intracellular perforin and ...
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Cd8+ T Cell Effector Function And Transcriptional Regulation During Hiv Pathogenesis
... and function identified the T-box transcription factors T-bet and eomesodermin (Eomes) as potential targets for manipulation that might induce more robust cytotoxic CD8 + T cell responses to HIV ...
154
The IL 21 receptor augments Th2 effector function and alternative macrophage activation
... macrophage function, because our in vivo data showed a marked reduction in several genes that have been associated with the “alternatively activated” phenotype (33, ...
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Fc effector function contributes to the activity of human anti-CTLA-4 antibodies.
... innate effector cells in B16 tumors relative to the more immunogenic MC38 and MCA205 models (Figure ...innate effector cells relative to MCA205 and MC38 (Figure ...
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Redefining the role of tumour necrosis factor in macrophage differentiation and effector function in bacterial and tumour defences
... Macrophage phagocytosis is a critical function in defence against pathogens. The role of TNF in macrophage phagocytosis was investigated with the tumour cells causing Devil Facial Tumour Disease (DFTD). TNF has no ...
157
A rheumatoid factor paradox: inhibition of rituximab effector function
... Normal human B cells were used as an alternative model to study the role of RF on rituximab function. We have previously shown that, in contrast to the Daudi lymphoblastoid cell line, human peripheral blood cells ...
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Altered effector function of peripheral cytotoxic cells in COPD
... in COPD subjects has not been previously reported. By measuring the proteins at the same time and in the same cell it was possible to identify that the cells that express both perforin and granzyme B, were reduced in ...
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The role of Fc gamma receptors in the activity of immunomodulatory antibodies for cancer
... that effector function enabled antibodies represent a risk to activity due to depletion of key immune cell ...mediated effector function are far from ...
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Resting CD4+effector memory T cells are precursors of bystander activated effectors: a surrogate model of rheumatoid arthritis synovial T cell function
... The proportions of cells positive for the adhesion markers CD18, CD29 and CD49d did not increase substantially in cul- ture, because more than 70% of the resting cells were already positive for these markers at day 0. ...
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Pouring fuel on the fire: Th17 cells, the environment, and autoimmunity
... and effector func- tion of self-reactive CD4 Th cells into pathologic effector ...well-defined effector Th subsets include Th1 cells, which make IFN-γ; Th2 cells, which produce IL-4; and Th17 cells, ...
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Compromised Influenza Virus-Specific CD8+-T-Cell Memory in CD4+-T-Cell-Deficient Mice
... memory T-cell pool measured by tetramer staining (Table 1) was reduced, and the remaining memory T cells generated a diminished secondary response (Fig. 4). The earlier finding that the extents of CTL effector ...
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Inhibition of Notch1 induces population and suppressive activity of regulatory T cell in inflammatory arthritis
... The suppression of inflammatory arthritis by inhibition of Notch signalling in CIA and CAIA models might be due to dampening of T cell recruitment and decline of the effector function of T and B cells ...
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Molecular pathways: targeting CD96 and TIGIT for cancer immunotherapy
... 43. Inozume T, Yaguchi T, Furuta J, Harada K, Kawakami Y, Shimada S. Melanoma Cells Control Antimelanoma CTL Responses via Interaction between TIGIT and CD155 in the Effector Phase. J Invest Dermatol. ...
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Regulation of CD8+ T cell responses to Toxoplasma gondii
... Though different NF-!B family members have also been shown to be involved in a variety of cellular processes in diverse cell types including neurons, hepatocytes and osteoclasts, for the purposes of this thesis I will ...
142
Driving adenovirus type 12-transformed BALB/c mouse cells to express high levels of class I major histocompatibility complex proteins enhances, rather than abrogates, their tumorigenicity.
... Thus, synergism between nonspecific effector cell function, class I MHC expression, and interleukin production is a thymus-dependent mechanism that could contribute to the differences in[r] ...
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Nervous Control of the Salivary Glands of the Carnivorous Mollusc Philine Aperta
... Properties of some gastropod salivary effector neurones Philine Effector neurone projections to salivary nerve Gland cell response to effector neurone stimulation Electrical coupling bet[r] ...
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Requirement for an Intact T-Cell Actin and Tubulin Cytoskeleton for Efficient Assembly and Spread of Human Immunodeficiency Virus Type 1
... with effector cells for the stated times and DNA extracting and analyzing as described ...pretreated effector cells with actin-depolymerizing agents cytochalasin D and latrunculin and the actin-stabilizing ...
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Tumoricidal efficacy coincides with CD11c up-regulation in antigen-specific CD8+ T cells during vaccine immunotherapy
... Next, we assessed the parallelism between the CD11c expression level and the ratio of OVA-specific T cells. They appeared to be positively correlated (Fig. 3c); hence, we separated CD11c − , CD11c lo-mid and CD11c hi ...
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