Endothelial differentiation
Sunitinib but not VEGF blockade inhibits cancer stem cell endothelial differentiation
... of endothelial differentiation markers by B-CSC infected with lentiviruses carrying an empty vector (Ctl) or the soluble VEGF trap sFlk1 (sFLK1 cells) or treated with an anti-VEGFR2 and an anti-VEGFR1 ...
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MicroRNAs as Modulators of Endothelial Differentiation of Stem Cells
... MicroRNAs (miRs) are a class of small (~22 nucleotides), widely distributed, and highly conserved non-coding RNA molecules and play an important post-transcriptional regulatory role by targeting mRNA. Embryonic and ...
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The effect of bisphosphonates on the endothelial differentiation of mesenchymal stem cells
... the endothelial differentiation potential of human term placental mesenchymal stem cells (pMSCs) in order to assess whether a perturbation in stem cell differentiation by BPs could play a role in the ...
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MiR 9 and miR 200 regulate PDGFRβ mediated endothelial differentiation of tumor cells in triple negative breast cancer
... In vivo experiments support the effect of miR-9 knock down and miR-200 restoration in the impairment of vascular lacunae formation. The approach of miRNA-based drug delivery raised two interesting considerations. First, ...
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Sphingosine-1-phosphate promotes the differentiation of adipose-derived stem cells into endothelial nitric oxide synthase (eNOS) expressing endothelial-like cells
... ASCs were isolated from human abdominal liposuction as- pirate as approved by the Cooper University Hospital Insti- tutional Review Board Committee. Briefly, the adipose tissue from liposuction aspirate was rinsed with ...
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Notch1 functions as a negative regulator of lymphatic endothelial cell differentiation in the venous endothelium
... venous/lymphatic differentiation in mammals uncovered a unique role for Notch in limiting lymphatic endothelial differentiation in ...blood endothelial Dll4 signals to adjacent lymphatic ...
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Hydrocortisone enhances the barrier properties of HBMEC/ciβ, a brain microvascular endothelial cell line, through mesenchymal-to-endothelial transition-like effects
... moting endothelial differentiation ...of endothelial cells allows them to change their phenotype from endo- thelial to mesenchymal, and vice versa, which are regarded as the ...
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Development of a new pre vascularized tissue engineered construct using pre differentiated rADSCs, arteriovenous vascular bundle and porous nano hydroxyapatide polyamide 66 scaffold
... (including endothelial differentiation) with bone-marrow derived mesenchymal stem cells (BMSCs), which are widely investigated in bone tissue engineering ...
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Hippo signaling components, Mst1 and Mst2, act as a switch between self renewal and differentiation in Xenopus hematopoietic and endothelial progenitors
... and endothelial progenitors is necessary during hematopoietic and endothelial ...and endothelial progenitors regula- tion in Xenopus HPEU\RJHQHVLV 7KHVH ÀQGLQJ LV LPSRUWDQW IRU identifying potential ...
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Multipotential stem cells recapitulate human infantile hemangioma in immunodeficient mice
... multilineage differentiation ability. To study cellular differentiation, we prepared clonal popula- tions from the HemSCs from 3 different proliferating phase IH ...of differentiation and later for ...
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Semaphorin3a regulates endothelial cell number and podocyte differentiation during glomerular development
... excess endothelial cells within glomerular capillaries, effaced podocytes with extremely wide foot processes and ...glomerular endothelial cell apoptosis, delayed and abnormal podocyte foot process ...
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Activation of monocytes and platelets by monoclonal antibodies or malaria infected erythrocytes binding to the CD36 surface receptor in vitro
... leukocyte differentiation antigen, recognized by MAbs OKM5 and OKM8 and found on human monocytes and endothelial cells, has been implicated as a sequestration receptor for erythrocytes infected with the ...
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Autophagy modulation altered differentiation capacity of CD146+ cells toward endothelial cells, pericytes, and cardiomyocytes
... According to WHO statistics, coronary heart disease is the main cause of human mortality in the clinical set- ting. Despite current advances in the decrease mortality rate in patients with coronary heart disease, further ...
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The regulation of myocardin factor dependent transcription in vascular smooth muscle
... that endothelial cell differentiation and initial formation of the dorsal aorta were unaffected, but staining for SM α -actin, a marker normally expressed in the aorta at this time-point, revealed a ...
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Mesenchymal stem cells for treating ocular surface diseases
... powerful differentiation capabilities and present immunosuppressive properties that aid them in surviving from host immune rejection for its great potential use in ...
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Gold nanoparticle interactions with endothelial cells cultured under physiological conditions
... vein endothelial cells (HUVEC) were isolated according to a previously published method 24 and cultured on gelatin-coated culture flasks using endothelial cell basal medium (ECBM; PromoCell), 15 % fetal ...
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The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling
... directed differentiation protocol to create human induced pluripotent stem cell (hiPSC)- derived endothelial cells (iECs) from patients with fibrodysplasia ossificans progressiva (FOP), a congenital disease ...
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Original Article Intramyocardial injection of heart-derived extracellular matrix combined with cardiosphere-derived cells improves myocardial structure and function in rats with acute myocardial infarction
... In the present study, our results indicated that intramyocardial injection of CDCs combined with heart-derived ECM could enhance the retention and survival of transplanted CDCs at 24 h and 3 weeks after AMI as compared ...
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Accelerated differentiation of human induced pluripotent stem cells to blood–brain barrier endothelial cells
... BBB differentiation [30], with no discernible ...the differentiation timeline without compromising BMEC performance as measured by TEER, sodium fluorescein permeability, and efflux transporter activity [24, ...
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Differentiation of Bone Marrow-Derived Endothelial Progenitor Cells Is Shifted into a Proinflammatory Phenotype by Hyperglycemia
... CD14 + cells have long been known to play a critical, paracrine role in neovas- cularization (22), and it is highly likely that “early outgrowth” EPC derived from CD14 + cells directly reflect the proangiogenic phenotype ...
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