endothelin-1,-2,-3
Endogenous endothelins mediate increased distal tubule acidification induced by dietary acid in rats
... higher endothelin-1 addition to renal interstitial fluid than those given distilled H2O (480+/-51 ...B-type endothelin receptors had higher HCO3 secretion than baseline (NH4)2SO4 animals ...A-type ...
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Neural peptidase endothelin converting enzyme 1 regulates endothelin 1–induced pruritus
... (Table 1). ETAR, ET-1, and ECE-1 colocalized with the peptidergic marker calcitonin gene–related peptide (CGRP) (ETAR, ...Table 1). Furthermore, 33% of ETAR- and ET-1–positive neurons ...
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Endothelin 3 induces hypertrophy of cardiomyocytes by the endogenous endothelin 1 mediated mechanism
... During the development of cardiomyocyte hypertrophy in- duced by neurohumoral factors, transcripts of several muscle- specific genes such as myosin light chain 2 (20), troponin I (5), and the skeletal a-actin ...
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Role of Endothelin 1/Endothelin A receptor mediated signaling pathway in the aortic arch patterning in mice
... (1, 2). Arch arteries 1 and 2 regress and become capillaries in branchial arches 1 and 2 by ...arteries 3 and 4 continue to ...arteries 3 remain to form bilateral ...
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Endothelin 1/endothelin B receptor–mediated increases in NHE3 activity in chronic metabolic acidosis
... When challenged with increased extrarenal acid gener- ation, the kidney increases renal acid excretion, pre- venting severe metabolic acidosis and complications such as bone demineralization, nephrolithiasis, and muscle ...
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Endothelin-1 gene polymorphisms and diabetic kidney disease in patients with type 2 diabetes mellitus
... intron 3 of the EDNRA gene was done by digesting polymerase chain reaction (PCR) products with the HhaI restriction enzyme (New Eng- land Biolabs, ...on 2 % agarose gels containing ethidium bromide and ...
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Verotoxin and ricin have novel effects on preproendothelin 1 expression but fail to modify nitric oxide synthase (ecNOS) expression and NO production in vascular endothelium
... bovine endothelin converting enzyme-1 (ECE-1) was generated by PCR (sense primer BE-1: 5 9 GCT CCT GGC GGC GGC ATT GGT G 3 9 ; antisense primer BE-2: 5 9 TCC TGG GGG ATG GTG ATG ...
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Endothelin and endothelin converting enzyme 1 in the fish gill: evolutionary and physiological perspectives
... 2006), 3·h post a FW j SW and a 2.6-fold increase 3·h post a SW j FW transfer, and the authors hypothesized that the increase in COX-2 is an important mechanism for gill cell survival during osmotic ...
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Disruption of ECE 1 and ECE 2 reveals a role for endothelin converting enzyme 2 in murine cardiac development
... from 1 µg of total RNA using SuperScript II RT (Life Technolo- gies ...94°C, 1 minute at 60°C, and 3 minutes at 72°C) were used for the RT- PCR of ECE-2 ...
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Pleiotropic effects of statins in distal human pulmonary artery smooth muscle cells
... (< 1 mm external diameter) ...= 3), lung transplantation for idiopathic PAH (IPAH, n = 3), emphysema or fibrotic lung disease (n = 9) and from unused donor lungs (n = ...(passages 3 to 12) ...
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Dual endothelin-converting enzyme/neutral endopeptidase blockade in rats with D-galactosamine-induced liver failure
... metalloprotease endothelin-converting enzyme (EcE)-1 is important for the production of active Et-1 by cleaving its pre- cursor big-Et-1 ...
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Ontogeny of endothelins 1 and 3, their receptors, and endothelin converting enzyme 1 in the early human embryo
... to 6 wk of gestation (prepro–ET-2 and ECE-2 were not stud- ied). This period encompasses intense and crucial morphogen- esis and organogenesis processes: closure of the NT and for- mation of cephalic ...
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Let-7a Is an Antihypertrophic Regulator in the Heart via Targeting Calmodulin
... Cardiac hypertrophy is a complex event, which is closely related to multiple cardiac dysfunctions. It has been reported that a number of miRNAs, such as miR-1 [24], miR-133 [25], miR-21 [26] and miR-208 [27] are ...
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Plasmatic Biochemical Variables Associated with Polymorphisms in the Endothelin-1 and Endothelin-1 Receptor a Genes in Hypertensive Patients: Pilot Study
... Studies that have linked SNPs to functional pathological effects have not been repeated by other research groups. Similarly, the majority of studies that link polymorphisms to phenotypes and/or diseases are either ...
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A novel PAX3 mutation in a Korean patient with Waardenburg syndrome type 1 and unilateral branch retinal vein and artery occlusion: a case report
... retinal vein occlusion followed by stasis of blood flow. An elevation of intraluminal capillary pressure caused by a patent central retinal artery seemed to result in BRAO in the same quadrant as the BRVO. Considering ...
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2 (1 Benzyl 1H indol 3 ylmethylene) 1 azabicyclo[2 2 2]octan 3 one
... added 1-aza-bicyclo[2.2.2]- octan-3-one hydrochloride ...of 1- benzyl-1H-indole-3-carboxaldehyde ...NaHCO 3 solution at 273 K and ...
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(2E) 1 (3 Bromophenyl) 3 (2 thienyl)prop 2 en 1 one
... In the crystal packing, for the major component, there are no intermolecular interactions. However, for the minor component, molecules are linked by intermolecular C11X— H11B Br1 i interactions (Table 1) and S1X ...
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rog 1 3 2 1 pdf
... For example, the start parameter 'Gpi: 14:00:00,14:05:59,0:1,01:00' has a window start time of 14:00:00 [2:00:00 PM], a window end time of 14:05:59, looks for a GPI event on line 0:1 and will wait one ...
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Crystal structures of (2E) 1 (3 bromothiophen 2 yl) 3 (2 methoxyphenyl)prop 2 en 1 one and (2E) 1 (3 bromothiophen 2 yl) 3 (3,4 dimethoxyphenyl)prop 2 en 1 one
... (3-bromo-2-thiophen-2-yl)-3-(dimethoxyphenyl)prop- 2-en-1-one types of compounds similar to the title compounds in this study and will be referred to as (III) ...
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3 (3 Bromophenyl) 1 phenylprop 2 en 1 one
... C7 0.0134 (4) 0.0230 (5) 0.0161 (4) −0.0015 (3) 0.0033 (3) 0.0019 (3) C8 0.0133 (4) 0.0230 (5) 0.0159 (4) −0.0019 (3) 0.0035 (3) −0.0001 (3) C9 0.0129 (4) 0.0231 (5) 0.0170 (4) ...
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