Endothelin-1 (ET-1)
Neural peptidase endothelin converting enzyme 1 regulates endothelin 1–induced pruritus
... diseases. Endothelin 1 (ET-1) evokes histamine-independent pruritus in mammals through activation of its cognate G protein–coupled receptor endothelin A receptor ...enzyme 1 ...
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Endothelin 1, superoxide and adeninediphosphate ribose cyclase in shark vascular smooth muscle
... wall. Endothelin-1, which is produced by the vascular endothelium, acts locally to cause ...well, ET-1 is thought to have an important role in influencing gill function in the shark (Evans and ...
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Astrocytic endothelin-1 overexpression promotes neural progenitor cells proliferation and differentiation into astrocytes via the Jak2/Stat3 pathway after stroke
... astrocytic ET-1 played a deleterious role in cognitive function and progressive neurodegeneration associated with a short- term ischemia/longer-term reperfusion ...astrocytic ET-1 under mild ...
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Endothelin 3 induces hypertrophy of cardiomyocytes by the endogenous endothelin 1 mediated mechanism
... that endothelin-1 (ET-1) mediates angiotensin II-induced hypertrophy of cardiomyocytes as an autocrine/paracrine ...whether endothelin-3 (ET-3) induces hypertrophy of cultured ...
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Susceptibility of juvenile and adult blood–brain barrier to endothelin-1: regulation of P-glycoprotein and breast cancer resistance protein expression and transport activity
... the endothelin fam- ily are released by various cell types in brain, including endothelial cells and some glial cells, especially during inflammation ...effect, ET-1 is known to be a component of the ...
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Plasmatic Biochemical Variables Associated with Polymorphisms in the Endothelin-1 and Endothelin-1 Receptor a Genes in Hypertensive Patients: Pilot Study
... from Endothelin -1 studied the presence of cytosine homozygous genotype was less frequent in males (P = ...the ET-1 gene, the homozygous adenine deletion was associated to normal plasma levels ...
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Uric acid causes kidney injury through inducing fibroblast expansion, Endothelin-1 expression, and inflammation
... determine ET-1 level. The reaction mixture (1 μL) was then used as the template in a conventional PCR ...for 1 min, and the last extension was 72 °C for 10 ...
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Role of endothelin-1 in lung disease
... of ET-1 in lung allografts is unknown. The expression of ET-1 in nontransplanted human lungs is low and found primarily in the vascular endothelium ...of ET-1 in the airway ...
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Reduced extracellular pH increases endothelin 1 secretion by human renal microvascular endothelial cells
... of ET-1 are stored in vascular endo- thelial cells and most are released after synthesis (14, ...decreased ET-1 degrada- tion, increased release of preformed ET-1 from cellular ...
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Modulation of the Cardiomyocyte Hypertrophic Responses to Endothelin-1 by Adipocytes
... Adiponectin is a 30kDa protein also known as Acrp30 (adipocyte complement-related protein of 30 kDa). In addition to adipocytes, (Scherer et al. 1995) it is also synthesized by other organs such as placenta (Chen ...
158
The effect of mirabegron, used for overactive bladder treatment, on female sexual function: a prospective controlled study
... Monophosphate; ET-1: Endothelin-1; FSD: Female sexual dysfunction; FSFI: Female sexual function index; FSFI- Gr: Female sexual function index – greek; HCC: Human corpus cavernosum; ICS: ...
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Verotoxin and ricin have novel effects on preproendothelin 1 expression but fail to modify nitric oxide synthase (ecNOS) expression and NO production in vascular endothelium
... (VTs) 1 and 2 (Shiga toxin 1 and 2) with vascular en- dothelium is believed to play a central role in the pathogen- esis of the thrombotic microangiopathy and ischemic lesions characteristic of hemolytic ...
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A Study on Platelet Count-Splenic Diameter Ratio as a Non-Invasive Predictor of Oesophageal Varices in Cirrhosis
... LIST OF ABBREVIATIONS CC : CONTRACTILE CELL CI : CONFIDENCE INTERVAL OGD :OESOPHAGOGASTRODUODENOSCOPY OGV : ESOPHAGOGASTRIC VARICES ET-1 : ENDOTHELIN-1 EV : ESOPHGEAL VARICES EVL : ENDOS[r] ...
136
Original Article Protective effect of Ixeris sonchifolia hance injection against endothelial dysfunction in patients undergoing tourniquet ischemia
... (NO), endothelin-1 (ET-1), superoxide dismutase (SOD), creative kinase (CK), CK-MB and lactate dehydrogenase (LDH) activities were also measured respectively prior to anesthesia and 60 min ...
6
Macitentan inhibits the transforming growth factor β profibrotic action, blocking the signaling mediated by the ETR/TβRI complex in systemic sclerosis dermal fibroblasts
... both endothelin-1 (ET-1) and transforming growth factor beta (TGF-β) have been shown to play a key role in this ...process. ET-1, one of the three members of ET family, is ...
9
Changes in vasoactive pathways in congenital diaphragmatic hernia associated pulmonary hypertension explain unresponsiveness to pharmacotherapy
... the endothelin A (ETA) and B (ETB) receptors in human CDH as well as in the nitrofen rat model [6, ...7]. Endothelin-1 (ET-1) is a potent vasoconstrictor [8] and is increased in lung ...
12
Extracellular Vesicles in Cardiovascular Theranostics
... may progressively develop to cardiac remodeling. The major effector cells of fibrosis are activated FBs called myofibroblasts, a highly contractile cell type characterized by the appearance of α-smooth muscle actin ...
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Inverse baseline expression pattern of the NEP/neuropeptides and NFκB/proteasome pathways in androgen-dependent and androgen-independent prostate cancer cells
... ECE-1: endothelin converting enzyme 1; ECL: enhanced chemiluminescence; EMSA: electrophoretic mobility assay shift; FBS: fetal bovine serum; ET-1: endothelin-1; IFN: ...
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Original Article Roles of heat shock protein 70 toward hypoxia-inducible factor 1α (HIF-1α) blockade in newborn rats with hypoxia-induced pulmonary hypertension
... (HIF-1α), endothelin-1 (ET-1), and inducible nitric oxide synthase (iNOS) were measured at different time ...HIF-1α, ET-1, and iNOS in group H3 was reduced ...HIF-1α, ...
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Endothelins and Sarafotoxins: Peptides of Similar Structure and Different Function
... of endothelin receptors has been described in the different zones of the ...(12). Endothelin-1 is overtly increased in severe congestive heart failure (CHF) and thus is a likely candidate for the ...
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