engineered T cells
A new insight in chimeric antigen receptor-engineered T cells for cancer immunotherapy
... adoptive T-cell therapy are sev- eral hundred times higher than the baseline level, which typically causes a clinical syndrome including fever, hypotension, and neurological changes, potentially leading to rapid ...
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Engineered T cells targeting E7 mediate regression of human papillomavirus cancers in a murine model
... gene-engineered T cells has been challenging ...TCR T cell ...human cells or HPV-induced cancers, which makes its expression by healthy tissues highly ...TCR T cells is ...
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Chimeric antigen receptor-engineered T cells for cancer immunotherapy: progress and challenges
... to T cells ...transduced T cells were detected in 98% of patients with no evidence of integration-induced immortalization ...resting T cells and 30–45% of T cells ...
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A 3D microfluidic model for preclinical evaluation of TCR-engineered T cells against solid tumors
... immune cells as well as a function- al ...TCR-engineered T cells, but we also acquired specific evidence of the importance of inflammatory cytokines and O 2 levels for the optimum function of ...
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A self inactivating retrovector incorporating the IL 2 promoter for activation induced transgene expression in genetically engineered T cells
... CD8+ T-cells do not significantly induce IL-2 promoter as compared to CD4+ T-cells, we propose that the SINIL-2pr system would be especially useful in applications such as negative selection ...
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Isolation of T cell receptor specifically reactive with autologous tumour cells from tumour-infiltrating lymphocytes and construction of T cell receptor engineered T cells for esophageal squamous cell carcinoma
... Background: T cell receptor-engineered T cells (TCR-Ts) therapy is a promising cancer treatment ...high-avidity T cell receptors (TCRs) directed against neoantigens derived from somatic ...
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T cell receptor-engineered T cells for leukemia immunotherapy
... human T cell clone was efficiently trans- ferred and expressed in human peripheral blood T cells of patients with ...TCR-modified T cells displayed specific anti-tumor reactivity in ...
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Targeted cancer immunotherapy via combination of designer bispecific antibody and novel gene engineered T cells
... of T lymphocytes against tumor antigens can induce dramatic regression of advanced stage ...the T-cell receptor (TCR) and a target antigen is one promising approach to T-cell ...CD3+ ...
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Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors
... endogenous T cell receptors (TCRs) typically have a low affinity for self/tumor ...been engineered to strongly bind proteins expressed by tumors (14, ...robust T cell expansion, and, so far, CAR ...
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Targeting FLT3 in acute myeloid leukemia using ligand-based chimeric antigen receptor-engineered T cells
... tumor cells are ideal target candidates for CAR-T ...normal cells and ...that T cells transduced with a CAR-recognizing ERBB2 could also recognize low levels of ERBB2 on lung epithelial ...
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Flexible Targeting of ErbB Dimers That Drive Tumorigenesis by Using Genetically Engineered T Cells
... ADC software or a FACScalibur cytome- ter with Cellquest Pro software. Expres- sion of T1E28z, T1NA and EGF28z was demonstrated using the following: (a) mouse antihuman EGF monoclonal anti- body (clone 10825; R&D ...
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Cancer biomarkers for targeted therapy
... Tumor-associated antigens (TAA) or cancer biomarkers are major targets for cancer therapies. Antibody- based agents targeting the cancer biomarkers include monoclonal antibodies (MoAbs), radiolabeled MoAbs, bispecific ...
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T Cells Engineered with a Cytomegalovirus-Specific Chimeric Immunoreceptor
... different T cell-HFF combinations are shown. First row, T cells derived from cord blood (50% CD8 ⫹ and 50% CD4 ⫹ ); second and third rows, magnetic-bead-purified CD8 ⫹ T cells ...
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Chimeric antigen receptor-modified T cell therapy in chronic lymphocytic leukemia
... CAR-T cells activation and ...CAR-T cells, and the second gener- ation is most commonly ...TRUCK T cells [14] and CAR-T with suicide genes [15, ...CAR-T ...
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New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer
... with T cells engineered using recombinant retroviral vectors to express HLA-2 restricted high affinity T cell receptors (TCRs) specific for melanoma antigens MART-1 and gp100 ...autologous ...
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Rejection of Experimental Hodgkins Lymphoma by T Cells Engineered with a CD19 Chimeric Antigen Receptor
... tCD34+ T cells were not detectable in tumors until day 11 post infusion (Figure ...transduced cells required a period of expansion before migrating to the tumor site in suffi- cient numbers to effect ...
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Advancing Chimeric Antigen Receptor-Engineered T-Cell Immunotherapy Using Genome Editing Technologies: Challenges and Future Prospects
... receptor engineered-T (CAR-T) cells also named as living drugs, have been recently known as a breakthrough technology and were applied as an adoptive immunotherapy against different types of ...
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T cells genetically engineered to overcome death signaling enhance adoptive cancer immunotherapy
... therapeutic T cells used for adoptive immu- notherapy for both hematologic and solid cancers constitutively express Fas, the cognate receptor for ...human T cells to prevent FasL-induced ...
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Surface display of ACC deaminase on endophytic Enterobacteriaceae strains to increase saline resistance of host rice sprouts by regulating plant ethylene synthesis
... Genetically engineered plants expressing ACC deaminase activity are less subject to the deleterious effects of stress conditions on plant growth than non-transgenic plants [14, ...
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Hepatitis C Virus-Specific T Cell Receptor mRNA-Engineered Human T Cells: Impact of Antigen Specificity on Functional Properties
... NS5-69-redirected T cells relative to the UT control were analyzed with the functional annotation clustering tool in the Database for Annotation, Visualization and Integrated Discovery (DAVID), which ...
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