Entry inhibitor
Natural Variation in the V3 Crown of Human Immunodeficiency Virus Type 1 Affects Replicative Fitness and Entry Inhibitor Sensitivity
... on entry inhibitor sensitivity and overall replicative ...cell entry (5, 30, ...of entry inhibitors and other antiretroviral ...on entry inhibitor sensitivity in a context- ...
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A Low-Molecular-Weight Entry Inhibitor of both CCR5- and CXCR4-Tropic Strains of Human Immunodeficiency Virus Type 1 Targets a Novel Site on gp41
... various inhibitor types and addition times. If PF-68742 is a genuine viral entry inhibitor, its maximal efficacy should be significantly reduced if added after cell fusion had ...biosynthesis ...
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Enfuvirtide Resistance Mutations: Impact on Human Immunodeficiency Virus Envelope Function, Entry Inhibitor Sensitivity, and Virus Neutralization
... (HIV) entry inhibitor to be li- censed, targets a structural intermediate of the entry ...of entry inhibitors and neutralizing ...of entry inhibitors, including those targeting CD4 ...
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Trimeric Glycosylphosphatidylinositol-Anchored HCDR3 of Broadly Neutralizing Antibody PG16 Is a Potent HIV-1 Entry Inhibitor
... P G9 and PG16 are two recently isolated quaternary-structure- specific human monoclonal antibodies that neutralize 70 to 80% of circulating HIV-1 isolates (1). The crystal structure of PG16 shows that it contains an ...
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Identification of a Human Respiratory Syncytial Virus Cell Entry Inhibitor by Using a Novel Lentiviral Pseudotype System
... fusion inhibitor in clinical develop- ment (BMS-433771) and a licensed therapeutic F protein-targeting antibody ...hRSV entry cofactors and/or restriction factors between these cell ...entry ...
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Identification and Characterization of a Novel Broad-Spectrum Virus Entry Inhibitor
... Virus entry into cells is a multistep process that often requires the subversion of subcellular ...(JUNV) entry, we serendipitously uncovered the small molecule ZCL278, reported to inhibit Cdc42 function as ...
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Identification of a Broad-Spectrum Arenavirus Entry Inhibitor
... Arenavirus entry is mediated by this single virally encoded protein, categorized as a class I viral fusion protein (20, 26, 53), facilitating the effective use of pseudotypes for antiviral ...viral entry ...
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Punica granatum(Pomegranate) juice provides an HIV 1 entry inhibitor and candidate topical microbicide
... the entry inhibitor(s) from ...the entry inhibitors, retained anti- HIV-1 activity and also inhibited infection by herpes virus type 1, unlike the HIV-1 entry inhibitors which adsorbed onto ...
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Design of a Potent d-Peptide HIV-1 Entry Inhibitor with a Strong Barrier to Resistance
... The HIV gp41 N-trimer pocket region is an ideal viral target because it is extracellular, highly conserved, and essential for viral entry. Here, we report on the design of a pocket-specific D -peptide, ...
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Identification of a Small-Molecule Entry Inhibitor for Filoviruses
... viral entry by carrying out proteolysis of the EBOV-GP1 subunit ...CatL inhibitor tetrahydroquinoline oxocarbazate was reported to in- hibit EBOV infection at nanomolar concentrations ...other entry ...
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Identification of a gp41 Core-Binding Molecule with Homologous Sequence of Human TNNI3K-Like Protein as a Novel Human Immunodeficiency Virus Type 1 Entry Inhibitor
... Unlike T-20, which is much less effective against T-20-resistant strains than against T-20-sensitive strains, P20 showed similar potency against both T-20-sensitive and -resistant variants (Ta- ble 2). This result ...
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Characterization of resistance to a potent d peptide HIV entry inhibitor
... HIV-1 entry inhibi- tor (PIE12) that targets the HIV envelope protein (Env) using sequential rounds of mirror-image phage display and high-resolution structure-guided design ...viral entry. Our ...
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Expanded Tropism and Altered Activation of a Retroviral Glycoprotein Resistant to an Entry Inhibitor Peptide
... peptide inhibitor has recently been de- scribed and employed as a tool to investigate conformational changes in TM (14, 33, ...this inhibitor by passaging ASLV subtype A (ASLV-A) in the presence of pep- ...
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Closing two doors of viral entry: Intramolecular combination of a coreceptor and fusion inhibitor of HIV 1
... fusion inhibitor, BFFI, is an antibody-based entry inhibitor that combines the activity of an anti-CCR5 monoclonal anti- body with the activity of a fusion inhibitor in one mole- ...cycle ...
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Pre entry advertising, entry deterrence and multi informational signaling
... market entry if competition with the incumbent turns out to be unpro fi table, and thereby to avoid another fi nancial loss in addition to the sunk advertising ...from entry, even if he has carried out ...
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Door Entry Controllers Apartment Entry Phones Door Entry Phones Video Entry Phones Whole House Paging Enhanced Weather Protection
... 4 entry points and 4 Wiegand type card readers • Stores 250 tenant Touch Tone phone numbers and 250 entry codes • Programmable Master entry code & Maintenance Personnel entry codes • ...
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A. Inhibitor Preparation
... Results presented in table 1 show the effect of immersion period on the inhibition efficiencies of PVAT for different concentrations in 1 M HCl at 30 o C. 0.6% PVA showed 72% inhibition efficiency. The results clearly ...
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INSTAGRAM ENTRY REQUIREMENTS
... (1) entry per person, regardless of method of entry, throughout the Sweepstakes ...the entry process will be ...the entry process are ...
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Adding entry information
... Adding entry information to a BioNumerics database can be done in two ways: either manually via the key- board, or with the import tools available in the ...
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Reduced Maximal Inhibition in Phenotypic Susceptibility Assays Indicates that Viral Strains Resistant to the CCR5 Antagonist Maraviroc Utilize Inhibitor-Bound Receptor for Entry
... HIV Entry assay occur because MVCres is able to bind to CCR5 in its normal conformation and in the maraviroc-bound ...HIV Entry assay (B) and with aplaviroc (C) and enfuvirtide (D) tested in ...HIV ...
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