Epigenetic Inheritance
Epigenetic inheritance and the missing heritability
... established. Epigenetic programs may account for a significant fraction of the “ missing ...” Epigenetic modifications, such as DNA methylation and chromatin assembly states, reflect the high plasticity of ...
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Histone Deacetylase Homologs Regulate Epigenetic Inheritance of Transcriptional Silencing and Chromosome Segregation in Fission Yeast
... clr3-735 and clr6-1 alleles, respectively. Upon retransformation, current models of structural organization at the mating- both plasmids complemented mutant phenotypes of the re- type region and at centromeres in S. ...
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Epigenetic inheritance of an inducibly nucleosome-depleted promoter and its associated transcriptional state in the apparent absence of transcriptional activators
... tin. Distinction between these two possibilities will be important for understanding the molecular basis of the epigenetic inheritance of a nucleosome-depleted state. The replication machinery is a highly ...
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Transgenerational Epigenetic Inheritance Is Negatively Regulated by the HERI-1 Chromodomain Protein
... Transgenerational epigenetic inheritance (TEI) is the inheritance of epigenetic information for two or more ...RNAi inheritance or RNA-directed ...RNAi inheritance to last longer ...
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Systems genomics analysis centered on epigenetic inheritance supports development of a unified theory of biology
... Fig. 2. Gene networks in germline transmission. (A) Over-representation of miRNAs common to exosomes, body fluids, spermatozoa, ovum and all other tissues indicated below the bars shown in Fig. 1B except fetus, total 18 ...
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Adaptive Resistance in Bacteria Requires Epigenetic Inheritance, Genetic Noise, and Cost of Efflux Pumps
... requires epigenetic inheritance and heteroge- neity of gene expression patterns that are, in particular, associated with the production of porins and efflux ...which inheritance and vari- ability ...
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Epigenetic Inheritance of 5-AZA-2'-Deoxycytidine (5-AZA-CdR) Induced Alterations
... major epigenetic modifications of the ...that epigenetic modifications are acquired in the developing mouse embryo, and erased in the germline to restore the totipotency of the genome in the next ...of ...
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Inducible mouse models illuminate parameters influencing epigenetic inheritance
... transgenerational inheritance of epigenetic lesions (via eggs) was observed only at the transgenes integrated at the Col1a1 ...the inheritance of not only repressive but also activating ...induced ...
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Epigenetic Inheritance of Transcriptional Silencing and Switching Competence in Fission Yeast
... or clr4 are mutated or deleted but not dramatically so. Im- pairing these functions does not allow much expression of the mating-type genes from the normally silent loci ei[r] ...
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Hermann, Stefanie Monika (2018): Functional and biochemical characterization of the epigenetic inheritance of an artificial centromere. Dissertation, LMU München: Medizinische Fakultät
... 2009). Epigenetic modifications fulfil several important functions besides the specification of cells to mitotically inheritable ...mitosis. Epigenetic marks, like the centromere specific histone variant ...
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Inter- and transgenerational epigenetic inheritance: evidence in asthma and COPD?
... with epigenetic changes in relation to asthma and COPD, there is very few human data available regarding the effect of grand- parental exposures on disease risk in grandchildren and even less with information on ...
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The Evolutionary Gene and the Extended Evolutionary Synthesis
... of epigenetic inheritance, for it only adds a new twist to the idea that an adequate understanding of evolutionary dynamics requires taking development out of its ‘black ...
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Epigenetics as a source of variation in comparative animal physiology – or – Lamarck is lookin' pretty good these days
... The epigenetic literature is now replete with evidence for epigenetic effects in everything ranging from longevity to behavior to morphology to molecular function (see references cited in the paragraphs ...
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Reduced PRC2 function alters male germline epigenetic programming and paternal inheritance
... of epigenetic information in the germline and its inherit- ance in the following generation is poorly ...heritable epigenetic information that significantly affects paternal offspring ...mediates ...
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Uncoupling of Genomic and Epigenetic Signals in the Maintenance and Inheritance of Heterochromatin Domains in Fission Yeast
... of epigenetic inheritance of chromatin states in fission yeast, as measured by both gene expression and presence of chromatin modifications associated with transcriptionally si- lent ...for epigenetic ...
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Neurobiological disease etiology and inheritance: an epigenetic perspective
... suggests epigenetic inheritance as the germ cells giving rise to this generation are never exposed to stress, and therefore must carry a trace of the initial stress in their epigenome (as a change in DNA ...
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Epigenetic memory and parliamentary privilege combine to evoke discussions on inheritance
... The role of the growth arrest and DNA damage 45 (Gadd45) protein in DNA repair, unscheduled synthesis and its contribution in removing 5-methylcytosine residues from DNA was discussed by Christof Niehrs (Institute of ...
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RNA: a possible contributor to the 'missing heritability’
... major epigenetic marks, namely DNA methylation and chromatin structure, are likely to be involved in both maternal and paternal ...in epigenetic regulation ...
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Alterations in sperm DNA methylation, non-coding RNA and histone retention associate with DDT-induced epigenetic transgenerational inheritance of disease
... of epigenetic transgenerational inheritance of alterations in sperm non-coding RNA (ncRNA) involved stress-induced alter- ations in behavior and injection of the sperm ncRNA into eggs to generate the ...
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The catalytic subunit of Arabidopsis DNA polymerase α ensures stable maintenance of histone modification
... distinctive epigenetic defects with the knockout mutants of chromatin assembly factors in Arabidopsis (Figs 2, 4; supplementary material ...diverse epigenetic defects in Arabidopsis and mammals with ...
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