Epistasis and the evolution of novel traits
Epistasis, Shapes and Evolution
... for evolution, epistasis is also quite preva- lent in ...inferring epistasis from experimental and theoretical fitness land- ...sign epistasis mo- tifs and presence of higher order ...returns ...
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Evolution Can Favor Antagonistic Epistasis
... The epistasis that exists among these deleterious mutations is determined by several ...make epistasis more antagonistic than to make it more synergistic, or vice ...change epistasis may also tend to ...
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Effect of Varying Epistasis on the Evolution of Recombination
... negative epistasis prevail over the detrimental effects of recombination with positive ...of epistasis does not predict the average amount of linkage disequilibrium generated or the impact on a ...
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Epistasis and the Dynamics of Reversion in Molecular Evolution
... protein evolution contend that the longer an amino acid substitution is present at a site, the less likely it is to revert to the amino acid previously occupying that ...of epistasis, the longer a ...
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Simulating evolution in asexual populations with epistasis
... simulating evolution with OncoSimulR is ...Once epistasis or, equivalently, fitness of genotypes has been specified, as explained above (section ...simulate evolution using any of the oncoSimul* ...
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Polygenicity and Epistasis Underlie Fitness-Proximal Traits in the Caenorhabditis elegans Multiparental Experimental Evolution (CeMEE) Panel
... complex traits remains a major challenge in ...and epistasis contribute to phenotypic variance in ways that are rarely ...experimental evolution (CeMEE) ...experimental evolution for 140–190 ...
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Polygenicity and Epistasis Underlie Fitness-Proximal Traits in the Caenorhabditis elegans Multiparental Experimental Evolution (CeMEE) Panel
... Polygenicity and epistasis underlie fitness-proximal traits in the Caenorhabditis elegans multiparental experimental evolution (CeMEE) panel Luke M. Noble ∗,1 , Ivo Chelo † , Thiago Guzella § , Bruno ...
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Stickbreaking: A Novel Fitness Landscape Model That Harbors Epistasis and Is Consistent with Commonly Observed Patterns of Adaptive Evolution
... Anna C. Nagel,* Paul Joyce, †,‡ Holly A. Wichman,* and Craig R. Miller* ,†,1 *Department of Biological Sciences, † Department of Mathematics, and ‡ Department of Statistics, University of Idaho, Moscow, Idaho 83843 ...
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The Evolution of Sex and Recombination in Response to Abiotic or Coevolutionary Fluctuations in Epistasis
... fluctuating epistasis, and ...fluctuating epistasis. We first analyze the evolution of sex and recombination when the temporal fluctuations are driven by the abiotic ...the evolution of sex ...
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The Evolution of Epistasis and Its Links With Genetic Robustness, Complexity and Drift in a Phenotypic Model of Adaptation
... positive epistasis was selected for in the presence of recombination; here, positive epistasis is selected for when drift is ...the evolution of finite asexual populations in which the best genotype ...
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Stability-Mediated Epistasis Restricts Accessible Mutational Pathways in the Functional Evolution of Avian Hemoglobin
... By reconstructing and resurrecting the Hb of the H. decus- sata/H. longirostris ancestor, we deduced that H. decussata evolved a derived reduction in Hb-O 2 affinity. We then used a combinatorial protein engineering ...
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teosinte branched1 and the origin of maize: evidence for epistasis and the evolution of dominance.
... Complementation tests indicate that one of these, which is on chromosome arm lL, is the locus for the maize mutant teosinte branchedl ( t b l ). This QTL has effects on infl[r] ...
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Epistasis analysis uncovers hidden antibiotic resistance associated fitness costs hampering the evolution of MRSA
... Results: Epistasis analysis on two collections of MRSA provides an explanation for this discord, where the mupirocin resistance-conferring mutation of the ileS gene appears to affect the levels of toxins produced ...
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Epistasis from functional dependence of fitness on underlying traits
... how epistasis at a low-level phenotype affects epistasis at higher ...the evolution of sexual ...sign epistasis between two alleles, providing potential new avenues for studying the ruggedness ...
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Performance analysis of novel methods for detecting epistasis
... Although almost all methods in their respective arti- cles are demonstrated as computationally and statisti- cally useful tools in the coming era of large scale interaction mapping and several review articles [11,28-30] ...
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Dissection of the Genetic Architecture of Body Weight in Chicken Reveals the Impact of Epistasis on Domestication Traits
... be fixed by artificial selection for increased body weight early in domestication. Our results thus strongly suggest that the contribution of the loci detected in this wild 3 domestic intercross to phenotypic ...
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Statistical mechanics and the evolution of quantitative traits
... With epistasis for fitness or for the trait, the advantage would be greater, since we would then avoid following the full probability distribution, across the 2 n ...
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RaSaR: A Novel Methodology for the Detection of Epistasis
... Within this research, a combination of univariate and multivariate approaches is used within stages for feature filtering and analysis. During this research, the use of multiple testing is explored, and further ...
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Epistasis dominates the genetic architecture of Drosophila quantitative traits
... 2012) Epistasis—nonlinear genetic interactions between polymorphic loci—is the genetic basis of canalization and speciation, and epi- static interactions can be used to infer genetic networks affecting ...
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A strategy to apply quantitative epistasis analysis on developmental traits
... Methods: In the nematode Caenorhabditis elegans, we applied RNA interference on mutants to inactivate two genes, used an imaging system to quantitatively measure phenotypes, and developed a set of statistical methods to ...
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