Epithelial and Mesenchymal phenotype
Tissue remodelling in chronic bronchial diseases: from the epithelial to mesenchymal phenotype
... pulmonary epithelial cells obtained from healthy donors have shown that exposure to TGF-b induces a mesenchymal phenotype in these cells [29, ...of mesenchymal proteins like N-cadherin, ...
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Stability of the hybrid epithelial/mesenchymal phenotype
... E/M phenotype - transcription factor GRHL2 and microRNA ...EMT phenotype can be observed stably at a single-cell level in H1975 lung cancer cells in vitro, and knockdown of OVOL and GRHL2 can impair ...
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Incomplete cellular reprogramming of colorectal cancer cells elicits an epithelial/mesenchymal hybrid phenotype
... an epithelial or mesenchymal phenotype to the iPC cells, and the reprogramming-induced alterations in EMT and MET gene expression were generally reversible ...an epithelial/mesenchymal ...
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Post-transcriptional regulatory network of epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions
... (miRNA), Epithelial-to-mesenchymal transition (EMT), Mesenchymal-to-epithelial transition (MET) Introduction EMT is a process whereby epithelial cells lose both polar- ity and ...
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Epithelial to mesenchymal transition induces stem cell like phenotype in renal cell carcinoma cells
... Results: Our results showed that treatment with TGF-β/CsA led to loss of epithelial characteristics and gain of mesenchymal phenotype in vitro. Changes in shape and elastic properties of the cancer ...
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The basics of epithelial mesenchymal transition
... of mesenchymal phenotype, the mechanisms of EMT induction and progression vary dramatically from one setting to ...activated mesenchymal cells, notably myofibroblasts that produce excessive amounts ...
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Epithelial to mesenchymal transition and breast cancer
... the epithelial to mesenchymal phenotype, and the reverse ...normal-like epithelial cells undergoing ...the mesenchymal phenotype in primary tumors and metastases may prove to be ...
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Vitamin D and the epithelial to mesenchymal transition
... an epithelial phenotype, while those shown in red are related with a mesenchymal ...the mesenchymal phenotype is maintained during disease ...
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Clinical significance of epithelial-mesenchymal transition
... of epithelial-mesenchymal transition (EMT), a process where cells change their epithelial towards a mesenchymal phenotype, has gained overwhelming attention especially in the cancer ...
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The epigenetics of epithelial-mesenchymal plasticity in cancer
... 2. Epithelial-mesenchymal plasticity allows cancer cells to undergo functional adaptations during the invasion-metastasis ...of epithelial cells at the invasive edge of the tumor may lose ...
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The progression of epithelial-mesenchymal transformation in gliomas
... the epithelial-mesenchymal transition, mainly mediate E-cadherin repression and are overexpressed in glioma cells during ...from mesenchymal phenotype to epithelial-like ...
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BMP4 Signaling Is Able to Induce an Epithelial-Mesenchymal Transition-Like Phenotype in Barrett's Esophagus and Esophageal Adenocarcinoma through Induction of SNAIL2
... In epithelial neoplasms, cells are required to gain motile properties in order to metastasize, a process called ...EMT. Epithelial cells lose their cell-junctions and cell-extracellular matrix con- ...
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A Computational and Experimental Model of the Epithelial Mesenchymal Transition.
... the epithelial to the mesenchymal phenotype if they were to lose cell-to-cell contact due to the migration of neighboring cells in the presence of TGF- β ...the mesenchymal state are those ...
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Reciprocal regulation of the cholinic phenotype and epithelial- mesenchymal transition in glioblastoma cells
... of mesenchymal features as a result of epithelial-mesenchymal transition (EMT) thereby inducing tumor dissemination and chemo ...cholinic phenotype is characterized by high intracellular ...
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Thrombospondin 1 promotes an aggressive phenotype through epithelial-to-mesenchymal transition in human melanoma
... EMT-like phenotype and potentially implicates TGF-beta pathway activation in LRC to mediate tumor ...of phenotype switching as contributors to treatment ...
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Original Article Immunohistochemical detection of epithelial- mesenchymal transition associated with stemness phenotype in anaplastic thyroid carcinoma
... apy. Epithelial-mesenchymal transition (EMT) generating cells with stem cell characteristics have been reported to be associated with chemoradioresistance in cultured ...cell phenotype in ATC, and ...
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Changes in macrophage phenotype and induction of epithelial‐to‐mesenchymal transition genes following acute Achilles tenotomy and repair
... This study provided important insights into changes in macrophage phenotype and EMT-related genes following acute Achilles tenotomy and repair, but there are several limitations. We did not immobilize the ...
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Biomarkers for epithelial mesenchymal transitions
... mature phenotype to another exhibit the property of ...that epithelial and endothelial cells enjoy some of this plasticity, which is easily demonstrated by study- ing the process of ...
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Biomarkers for epithelial-mesenchymal transitions
... mature phenotype to another exhibit the property of ...that epithelial and endothelial cells enjoy some of this plasticity, which is easily demonstrated by study- ing the process of ...
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The epithelial-mesenchymal transition phenotype of metastatic lymph nodes impacts the prognosis of esophageal squamous cell carcinoma patients
... of mesenchymal markers coupled with a loss of epithelial features, in reality it usually produces cells residing within a spectrum of intermediate phenotypic states – often termed a “partial EMT” – where ...
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