Equilibrative nucleoside transporter 1
Ectopic Mineralization of Spinal Tissues in Mice Lacking Equilibrative Nucleoside Transporter 1
... Equilibrative nucleoside transporter 1 (ENT1) regulates the bi-directional transfer of hydrophilic nucleosides, such as adenosine, across the plasma ...pyrophosphatase/phosphodiesterase ...
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FLT3 is implicated in cytarabine transport by human equilibrative nucleoside transporter 1 in pediatric acute leukemia
... a nucleoside analog that requires membrane transport proteins of the human nucleoside transporters (hNT) gene families SLC28 and SLC29 to be internalized into target ...Concentrative Nucleoside ...
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Persistent Hepatitis C Virus Infection Impairs Ribavirin Antiviral Activity through Clathrin-Mediated Trafficking of Equilibrative Nucleoside Transporter 1
... through nucleoside transporters, such as equilibrative nucleoside transporter 1 (ENT1), that are expressed on the plasma membrane of many cell types ...
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High expression of the human equilibrative nucleoside transporter 1 gene predicts a good response to decitabine in patients with myelodysplastic syndrome
... membrane nucleoside transporter proteins ...the equilibrative bi-directional facilitators (hENT1 and 2) and the con- centrative sodium/nucleoside symporters hCNT1 and ...
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Modeling interactions between Human Equilibrative Nucleoside Transporter 1 and other factors involved in the response to gemcitabine treatment to predict clinical outcomes in pancreatic ductal adenocarcinoma patients
... Focusing on the investigation of interactions between hENT1, CHOP, MRP1 and DCK genes on OS and PFS outcome, RECPAM tree-growing algorithm identified three classes at different mortality risks. As shown in Figure 2A, the ...
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Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice
... that equilibrative nucleoside transporters (ENTs) terminate adenosine signaling, we observed that pharmacologic ENT inhibition in mice elevated renal adenosine levels and damp- ened ...
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Reduced Ribavirin Antiviral Efficacy via Nucleoside Transporter-Mediated Drug Resistance
... of equilibrative nucleoside transporter 1 (ENT1) or concentrative nucleoside transporter 3 (CNT3) increased RBV uptake in RBV-sensitive cell lines and restored the uptake defect ...
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Transient Down-Regulation of Nucleoside Transporter 3 Gene Expression as a Drug Target in Leishmania major Using Antisense RNA Technology
... the Equilibrative Nucleoside Transporter SLC29 family in the human genome database (8, 9) or the ...the transporter classifi- cation database (10). Nucleoside transporters are present ...
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Human Equilibrative Nucleoside Transporter Subtype 1: Structure-Function Analysis Using Cysteine Mutagenesis and Thiol Modifying Techniques
... of nucleoside formation is through a series of resourceful enzymatic cascades involving the breakdown of ...these nucleoside pools can have an important impact on their secondary function as signaling ...
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Uptake of purines in Plasmodium falciparum infected human erythrocytes is mostly mediated by the human Equilibrative Nucleoside Transporter and the human Facilitative Nucleobase Transporter
... of 1 mM extracellular nucleoside, whereas the present study used a more physiological concentration of ...that nucleoside uptake through NPP is possible, the present investigation has sought to ...
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Immunohistochemical expression of glucose transporter 1 in keratin-producing odontogenic cysts
... In head-and-neck area, GLUT1 was also overexpressed at particular times in some benign tumours [10, 11], par- ticularly those with marked proliferative activity [12]. Likewise, in some benign odontogenic tumors with high ...
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Monocarboxylate transporter 1 and monocarboxylate transporter 4 in cancer-endothelial co-culturing microenvironments promote proliferation, migration, and invasion of renal cancer cells
... Renal cell carcinoma (RCC) is the most common malig- nancy that originates in kidney, and it contributes to nearly 2.4% of whole cancer burden and 1.7% of all can- cer-related global deaths [1]. RCC is derived ...
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Automatic interpretation of nucleoside mass spectra
... The pattern recognition methods of statistical linear discriminant function analysis, learning machine approach, distance from the mean, and k-nearest neighbour classification have been [r] ...
262
The Role of Functional Dopamine Transporter SPECT Imaging in Parkinsonian Syndromes, Part 1
... SUMMARY: As we defeat infectious diseases and cancer, one of the greatest medical challenges facing us in the mid-21st century will be the increasing prevalence of degenerative disease. Those diseases, which affect ...
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Nucleoside and Nucleobase Transporters in Parasitic Protozoa
... the transporter function, despite the fact that the mutant permease was targeted correctly to the plasma membrane, suggesting an essential role of D389 in permease ...functional transporter, but mutations ...
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The enzymatic synthesis of nucleoside analogues
... Results with 1,2,3-triazole bases used as acceptors in the N-deoxyribosyltransferase reaction.. bases heterocyclic 5-membered pKa values of.[r] ...
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Benzophenone Derivatives: a Novel Scaffold as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors
... In 2011, Ma et al. [26] synthesized a class of N-phenylaryl formamide derivatives (PAFAs, 18a-i, Table 10), considering that the flexible amido linker between A and B rings might not only improve the adaptation of the ...
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Nonproductive Human Immunodeficiency Virus Type 1 Infection in Nucleoside-Treated G0 Lymphocytes
... described (11). Purified cells were cultured in RPMI 1640 supplemented with 10% human AB serum, 100 U of penicillin per ml, 100 mg of streptomycin per ml, and 2 mM glutamine. Cells were stimulated with 1 g of ...
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Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action
... cation transporter 1 (OCT1) plays a role in the hepatic uptake of metformin, but its role in the therapeutic effects of the drug, which involve activation of AMP-activated protein kinase (AMPK), is ...
11
Ependymal cells of the mouse brain express urate transporter 1 (URAT1)
... lactate transporter proteins, referred to as MCT1, MCT2 and MCT4 (monocarboxylate transporter 1, 2 and 4), have been identified in ependymal cells, probably on the basolateral side [25-29], the ...
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