Eukaryotic translation
Influenza A Virus-Induced Degradation of Eukaryotic Translation Initiation Factor 4B Contributes to Viral Replication by Suppressing IFITM3 Protein Expression
... cellular translation machinery occurs in virus-infected cells, the role of such alteration and the pre- cise pathogenic processes are not well ...of eukaryotic translation initiation factor 4B ...
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Functional role of eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) in NSCLC
... the eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) is related to tumorigenesis and tumor progression in breast cancer ...protein translation by serving as a scaffold and interacting with ...
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Genetic Interactions of Yeast Eukaryotic Translation Initiation Factor 5A (eIF5A) Reveal Connections to Poly(A)-Binding Protein and Protein Kinase C Signaling
... conserved eukaryotic translation initiation factor eIF5A has been proposed to have various roles in the cell, from translation to mRNA decay to nuclear protein ...
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Recent insights into eukaryotic translation initiation factors 5A1 and 5A2 and their roles in human health and disease
... The eukaryotic translation initiation factor 5A1 (eIF5A1) and its homolog eIF5A2 are the only two human proteins containing the unique post‑translational modification–hypusination, which is essential for ...
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Efficient Translation of Rotavirus mRNA Requires Simultaneous Interaction of NSP3 with the Eukaryotic Translation Initiation Factor eIF4G and the mRNA 3′ End
... the eukaryotic translation initiation factor ...efficient translation of virus-like ...mRNA translation by NSP3 was also observed in a rabbit reticulocyte lysate translation system ...
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Collybistin and gephyrin are novel components of the eukaryotic translation initiation factor 3 complex
... ~2.7 × 10 6 clones screened, 8 positive clones were iso- lated using the most stringent reporter selection. To ret- est protein-protein interaction in yeast, library plasmids were rescued and cotransformed into the AH109 ...
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Incorporation of Eukaryotic Translation Initiation Factor eIF4E into Viral Nucleocapsids via Interaction with Hepatitis B Virus Polymerase
... The DNA genome of hepatitis B virus (HBV) replicates via reverse transcription within capsids following the encapsidation of an RNA template, the pregenomic RNA (pgRNA). We previously demonstrated that the 5 ⴕ cap ...
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Eukaryotic translation initiation factor 3 subunit G (EI F3G) resensitized HC T116/5-Fu to 5-fluorouracil (5-Fu) via inhibition of MRP and MDR1
... Purpose: Colorectal cancer (CRC) has become a predominant cancer and accounts for approxi- mately 10% of cancer-related mortality. Drug resistance still remains a priority mortality factor for patients due to no ...
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Original Article Knockdown of eukaryotic translation initiation factor 3 subunit B inhibits cell proliferation and migration and promotes apoptosis by downregulating WNT signaling pathway in acute myeloid leukemia
... EIF3B, eukaryotic translation initiation factor 3 subunit B; AML, acute myeloid leukemia; Sh-EIF3B, eukaryotic translation initiation factor 3 subunit B short hairpin RNA plasmids and control ...
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Minimum Requirements for the Function of Eukaryotic Translation Initiation Factor 2
... Eukaryotic translation initiation factor 2 (eIF2) is a G protein heterotrimer required for GTP-dependent delivery of initiator tRNA to the ribosome. eIF2B, the nucleotide exchange factor for eIF2, is a ...
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The eukaryotic translation elongation factor 1A regulation of actin stress fibers is important for infectious RSV production
... protein eukaryotic translation elongation factor 1A (eEF1A) is an actin binding protein that plays a role in the formation of filamentous actin (F-actin) ...
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The deployment and mechanism of broad spectrum resistance to Turnip mosaic virus in Brassica rapa
... Recessive strain-specific resistance to a number of plant viruses in the Potyvirus genus has been found to be based on mutations in the eukaryotic translation initiation factor 4E ( eIF4E ) and its isoform, ...
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Review Article Autophagy, a process within reperfusion injury: an update
... Autophagy in ischemia/reperfusion injury kinase PERK, which through a series of activation of eukaryotic translation initiation factor 2α eIF2α kinase Fcn2 another energy sensor, induces[r] ...
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Helper Component Proteinase of the Genus Potyvirus Is an Interaction Partner of Translation Initiation Factors eIF(iso)4E and eIF4E and Contains a 4E Binding Motif
... the eukaryotic translation initiation factor eIF4E and the isoform eIF(iso)4E, which interact with viral genome-linked protein ...with translation initiation factors and were detrimental to the ...
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Characterization of poliovirus 2A proteinase by mutational analysis: residues required for autocatalytic activity are essential for induction of cleavage of eukaryotic initiation factor 4F polypeptide p220.
... A second function of 2APro in poliovirus infection of HeLa cells is in inducing cleavage of the 220-kDa polypeptide p220 component of eukaryotic translation initiation factor eIF-4F 8, 9[r] ...
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eIF5B increases ASAP1 expression to promote HCC proliferation and invasion
... expression eukaryotic translation initiation factor 5B (eIF5B) was significantly correlated with aggressive characteristics and associated with shorter recurrence-free survival (RFS) and overall survival ...
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<p>eIF2α promotes vascular remodeling via autophagy in monocrotaline-induced pulmonary arterial hypertension rats</p>
... of eukaryotic translation initiation factor 2, which is a key protein that catalyzes the initiation of protein ...the translation initiation factor family, plays a key role in the regulation of cell ...
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Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model
... As eukaryotic translation initiation factor 4E (eIF4E) cooperates with c-Myc during lymphomagenesis, induces drug resistance, and is a genetic modifier of the rapamycin response, we have investigated the ...
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MicroRNAs from plants to animals, do they define a new messenger for communication?
... eIF: Eukaryotic translation initiation factor; EPDENs: Edible plant derived exosome-like nanoparticles; FSH: Follicle-stimulating hormone; GI: Gastrointestinal; GTP: Guanosine triphosphate; GW182: ...
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Avian Reovirus Nonstructural Protein p17-Induced G2/M Cell Cycle Arrest and Host Cellular Protein Translation Shutoff Involve Activation of p53-Dependent Pathways
... karyotic translation initiation factor 2 ␣ (eIF2 ␣ ) on serine 51 increases its affinity for the guanine nucleotide exchange factor eIF2B (18), causing a general inhibition of translation ...cellular ...
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