eukaryotic translation initiation factor 2
Minimum Requirements for the Function of Eukaryotic Translation Initiation Factor 2
... Eukaryotic translation initiation factor 2 (eIF2) is a G protein heterotrimer required for GTP-dependent delivery of initiator tRNA to the ...exchange factor for eIF2, is a ...
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Diverse roles of endoplasmic reticulum stress sensors in bacterial infection
... : eukaryotic translation initiation factor 2 α ; ER: endoplasmic reticulum; ERAD: ER-associated degradation; ESAT-6: early secretory antigenic target 6; Grp94: heat shock protein 90 kDa ...
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Cell-Type-Specific Growth Restriction of Vesicular Stomatitis Virus polR Mutants Is Linked to Defective Viral Polymerase Function
... of eukaryotic translation initiation factor 2 (eIF-2 ␣ ) was enhanced ⬃ 3-fold in polR versus wild-type virus-infected L-929 cells, but neither inhibition of host gene ...
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Restoring synaptic plasticity and memory in mouse models of Alzheimer’s disease by PKR inhibition
... of eukaryotic translation initiation factor 2 α (eIF2 α ) was shown to enhance long-term memory and synaptic plasticity in naïve ...
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<p>eIF2α promotes vascular remodeling via autophagy in monocrotaline-induced pulmonary arterial hypertension rats</p>
... of eukaryotic translation initiation factor 2, which is a key protein that catalyzes the initiation of protein ...the translation initiation factor family, ...
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Avian Reovirus Nonstructural Protein p17-Induced G2/M Cell Cycle Arrest and Host Cellular Protein Translation Shutoff Involve Activation of p53-Dependent Pathways
... large initiation factor eIF4G, an interaction that is inhibited by association of eIF4E with the small 4E-binding proteins ...karyotic translation initiation factor 2 ␣ (eIF2 ␣ ) ...
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Interaction of eukaryotic initiation factor eIF-4B with a picornavirus internal translation initiation site.
... ' 95,000 was also labelled by UV cross-linking with different fragments of IRES RNA (Fig. 3, lanes 1 to 7). Its binding, however, was completely suppressed by an excess of heterolo- gous RNA (lane 13) and was therefore ...
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Genetic Interactions of Yeast Eukaryotic Translation Initiation Factor 5A (eIF5A) Reveal Connections to Poly(A)-Binding Protein and Protein Kinase C Signaling
... distribution in live cells, TIF5A was inserted downstream of a galactose-inducible green fluorescent protein gene. This plasmid produces functional eIF5A in that it re- stores the ability of tif51A-1 to grow at the ...
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Revisiting an old acquaintance: role for eIF5A in diabetes
... type 2 diabe- tes and appears to result in part from the local release of proinflammatory ...identify eukaryotic translation initiation factor 5A (eIF5A) as a critical regulator of the ...
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Functional role of eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) in NSCLC
... Lung cancer is a common malignant disease and the leading cause of cancer-related death in the world [1], which falls into the broad categories of non– small cell lung cancers (NSCLC, encompassing lung adenocarcinomas, ...
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Upregulation of a novel eukaryotic translation initiation factor 5A (eIF5A) in dengue 2 virus infected mosquito cells
... Expression of eIF5A in C6/36 cells was analyzed follow- ing Den-2 virus and UV-inactivated Den-2 virus infec- tion. C6/36 cells were infected with either the Den-2 virus or a UV-inactivated ...
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Influenza A Virus-Induced Degradation of Eukaryotic Translation Initiation Factor 4B Contributes to Viral Replication by Suppressing IFITM3 Protein Expression
... cellular translation machinery and its role during the viral infection have come into the focus of interest ...the translation of host mRNAs, thereby suppressing host innate defenses ...of eukaryotic ...
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Original Article Knockdown of eukaryotic translation initiation factor 3 subunit B inhibits cell proliferation and migration and promotes apoptosis by downregulating WNT signaling pathway in acute myeloid leukemia
... AML pathology by enhancing proliferation of hematopoietic stem and progenitor cells [9-11, 17]. Based on previous studies, we speculat- ed that EIF3B might affect the AML cell activi- ties by activating the WNT signaling ...
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Collybistin and gephyrin are novel components of the eukaryotic translation initiation factor 3 complex
... ~2.7 × 10 6 clones screened, 8 positive clones were iso- lated using the most stringent reporter selection. To ret- est protein-protein interaction in yeast, library plasmids were rescued and cotransformed into the AH109 ...
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Frequent activation of EGFR in advanced chordomas
... using immunoprecipitation assay, EGFR and HER2 were phosphorylated in respectively 17/22 (77%) and 6/14 (43%) of their cases [8]. Using the same RTK antibody array, Shalaby and colleagues recently showed activation of ...
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Multiple isoelectric forms of poliovirus RNA-dependent RNA polymerase: evidence for phosphorylation.
... The host cell protein required for in vitro replication of poliovirus is a protein kinase that phosphorylates eukaryotic initiation factor 2.. ATP is required for initiation of polioviru[r] ...
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The eukaryotic translation elongation factor 1A regulation of actin stress fibers is important for infectious RSV production
... protein eukaryotic translation elongation factor 1A (eEF1A) is an actin binding protein that plays a role in the formation of filamentous actin (F-actin) ...cellular factor eEF1A plays an ...
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Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model
... cap-dependent translation in ...ated translation in 293 cells transfected with ...for 2 hours in the presence of vehicle (DMSO), thapsigargin (2 μ g/ml), or silvestrol (400 nM), after which ...
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Review Article Autophagy, a process within reperfusion injury: an update
... survive the severely limiting conditions during ischemia, while it is a quest for survival follow- ing the overwhelming activation of cellular pro- cesses during reperfusion. The importance of I/R injury lies in the fact ...
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High expression of eIF3d is associated with poor prognosis in patients with gastric cancer
... A total of 210 patients with GC who had received curative gas- trectomy in the Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China, between January 2006 and October 2010 were enrolled in ...
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