Eukaryotic translation initiation factor 3
The eukaryotic translation initiation factor 3 subunit L protein interacts with FlavivirusNS5 and may modulate yellow fever virus replication
... human eukaryotic translation initiation factor 3 (eIF3L) is one of the subunits of the mammalian translation initiation factor eIF3 ...eIF3 factor plays a ...
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Original Article Knockdown of eukaryotic translation initiation factor 3 subunit B inhibits cell proliferation and migration and promotes apoptosis by downregulating WNT signaling pathway in acute myeloid leukemia
... of eukaryotic translation initiation factor 3 subunit B (EIF3B) on cell proliferation, migration, and apoptosis as well as the underlying mechanism in acute myeloid leukemia ...
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Eukaryotic translation initiation factor 3 subunit G (EI F3G) resensitized HC T116/5-Fu to 5-fluorouracil (5-Fu) via inhibition of MRP and MDR1
... mortality factor for patients due to no available therapeutic ...how eukaryotic translation initiation factor 3 subunit G (EIF3G) resensitized 5-Fu-resistant human CRC cells ...
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Collybistin and gephyrin are novel components of the eukaryotic translation initiation factor 3 complex
... For immunoprecipitation from HEK 293T cell lysates, ~1.5 mg of protein were pre-cleared with protein G- Sepharose (GE Healthcare) and then incubated with anti- body (4 mg) against the Flag epitope, overnight at 4°C on a ...
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Genetic Interactions of Yeast Eukaryotic Translation Initiation Factor 5A (eIF5A) Reveal Connections to Poly(A)-Binding Protein and Protein Kinase C Signaling
... To further test the dependence of Rev export upon eIF5A, GFP-Rev localization was examined in strains containing the TIF51A temperature-sensitive alleles. After a 3-hr shift to the nonpermissive temperature, ...
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Interaction of eukaryotic initiation factor eIF-4B with a picornavirus internal translation initiation site.
... (Fig. 3, lanes 1 to ...the 3 * part of the ...and 3 but not with those carrying a deletion of stem-loop ...the 3 9 -terminal half of stem-loop 5 or insertion of a se- quence of six nucleotides ...
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Influenza A Virus-Induced Degradation of Eukaryotic Translation Initiation Factor 4B Contributes to Viral Replication by Suppressing IFITM3 Protein Expression
... ⫽ 3) and harvested at the indicated times, followed by Western blotting with the indi- cated ...for 3 days were sacrificed, and the lungs (C) and thymus, spleens, and livers (D) were homogenized, followed ...
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<p>eIF2α promotes vascular remodeling via autophagy in monocrotaline-induced pulmonary arterial hypertension rats</p>
... of eukaryotic translation initiation factor 2, which is a key protein that catalyzes the initiation of protein ...the translation initiation factor family, plays a ...
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Efficient Translation of Rotavirus mRNA Requires Simultaneous Interaction of NSP3 with the Eukaryotic Translation Initiation Factor eIF4G and the mRNA 3′ End
... a 3⬘ terminal poly(A) ...the 3⬘ poly(A) and the eukaryotic initiation factor eIF4G (14, 23, ...first initiation codon ...the translation of the mRNA by allowing rapid ...
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Cell-Type-Specific Growth Restriction of Vesicular Stomatitis Virus polR Mutants Is Linked to Defective Viral Polymerase Function
... ⬃ 3-fold less in hamster BHK ...of eukaryotic translation initiation factor 2 (eIF-2 ␣ ) was enhanced ⬃ 3-fold in polR versus wild-type virus-infected L-929 cells, but neither ...
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Minimum Requirements for the Function of Eukaryotic Translation Initiation Factor 2
... capped eukaryotic messenger RNAs in a process that highly similar to eubacterial elongation factor EF1A appears to involve interactions between eIF3 and pro- (formerly EF-Tu; Hannig et ...
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Functional role of eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) in NSCLC
... Cells were seeded onto coverslips in a 6-well plate and fixed with 4% paraformaldehyde (w/v) for 30 min, and then were washed for 10 min with PBS and permeabilized with 0.2% (w/v) Triton X-100 in PBS for 5 min. Cells ...
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Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model
... Results are expressed as mean ± SEM of 2 experiments. (B) CBFs primarily impact protein synthesis in vivo. HeLa cells were incubated with 5 μM FA, 0.4 μM silvestrol, or vehicle (MeOH) for 1 hour. The rate of ...
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The eukaryotic translation elongation factor 1A regulation of actin stress fibers is important for infectious RSV production
... manner [11]. RSV requires actin for virus replication, and F-actin is reported to be important for viral tran- scription and morphogenesis. This is dependent on cel- lular profilin activity, which regulates F-actin ...
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Avian Reovirus Nonstructural Protein p17-Induced G2/M Cell Cycle Arrest and Host Cellular Protein Translation Shutoff Involve Activation of p53-Dependent Pathways
... virus translation or that the p17 protein play a direct role, partially explaining the p17 constant movement in and out of the nucleus (36, 39, ...host translation shutoff. The p17- induced host ...
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Frequent activation of EGFR in advanced chordomas
... Furthermore, by kinase antibody arrays, we also found effectors of RAS/ERK1/2 signaling to be significantly activated in chordoma, like ribosomal S6 kinases (RSK) 1/2/3, the CREB transcription factor and ...
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Potential of human PON2 as an anti pseudomonal therapy
... absorption and produces a CF like lung disease in the mice [42]. While a number of authors have claimed that under challenge with bacterial pathogens, CF mice find it more difficult to clear infection [377, 398, 399], ...
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Review Article Autophagy, a process within reperfusion injury: an update
... exposures of sublethal ischemia, the myoctes and tissue in course time develop adaptations, a form of cardioprotection called the ischemic preconditioning [88], which with reperfusion gets abolished and the drive for ...
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Studying Hepatitis C Virus: Making the Best of a Bad Virus
... for translation, replication, and ...and 3 ⬘ noncoding regions (NCRs) and the polyprotein coding region ...HCV translation initiation, the 40S ribo- some subunit interacts with the HCV IRES ...
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Identification of Gcn1 binding proteins and characterization of their effect on Gcn2 function : a thesis submitted in partial fulfillment of the requirements for the degree Doctor of Philosophy in Biochemistry, Massey University, Albany, New Zealand
... efflux, 3) proteins functioning downstream of Gcn2 activation such as Gcn4; (Gcn4 is the downstream effector of the GAAC pathway, is imported into the nucleus and transcribes the genes involved in stress response, ...
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