Eye Development
Homeobox genes in the genetic control of eye development
... complete eye developmental program in ectopic imaginal discs, while mutations in ey/pax6 cause malformation or lack of eyes in Drosophila, mouse and humans (Hill et ...in eye development has led to ...
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Eye development at the Houston "Fly Meeting"
... Drosophila eye model has also been exploited for many genome-wide and high throughput ...fly eye development and only a handful of RD genes are known to control this ...
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The Pax gene eyegone facilitates repression of eye development in Tribolium
... adult eye primordium development in Tribolium like in Droso- ...by eye gain instead of loss. In Drosophila, the development of the adult eye is not affected in het- erozygous eyg ...
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Meis1 coordinates a network of genes implicated in eye development and microphthalmia
... the eye only when the first retinal ganglion cells begin to differentiate (Gray et ...early eye alterations ...early eye formation. This predominant role of Meis1 in the mammalian eye ...
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The genetic control of eye development and its implications for the evolution of the various eye types
... the eye, a number of Droso- phila mutants have been isolated which block eye development by inducing cell death rather than leading to a homeotic transforma- ...of eye facets on one or both ...
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Regulation of vertebrate eye development by Rx genes
... of eye specific genes in Mrx-/- ...in development their expression is promi- nent in the retinal progenitor cells (Blitz and Cho, 1995; Oliver et ...
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Analysis of mouse eye development with chimeras and mosaics
... ABSTRACT Analysis of experimental mouse chimeras (chimaeras) and mosaics provides a means of investigating patterning and differentiation within the developing mammalian eye. Chimeric and mosaic mice carry two or ...
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Ectopic Expression of the Drosophila Cdk1 Inhibitory Kinases, Wee1 and Myt1, Interferes With the Second Mitotic Wave and Disrupts Pattern Formation During Eye Development
... normal development. Overexpression of Dwee1 or Dmyt1 during eye development generates a rough adult eye ...the eye overexpression phenotypes and identified several loci as dominant ...
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In Utero Eye Development Documented by Fetal MR Imaging
... fetal eye development has also been described by prenatal sonography and gross anatomic studies of ...The eye begins to develop at approximately 22 days of fetal life when 2 indentations (the optic ...
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Pax 6, eyes absent, and Prox 1 in eye development
... Inl J Dev Bioi ~I 8J5 8~2 (1997) 835 Pax 6, Eyes absent, and Prox 1 in eye development STAN IS LA V I TOMAREV' Laboratory of Molecular and Developmental Biology, National Eye Institute, NIH, Bethesda,[.] ...
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Evolution of eye development in the darkness of caves: adaptation, drift, or both?
... In Astyanax cavefish, for which the genome is not fully available yet but soon should be (http://www.ncbi.nlm. nih.gov/assembly/GCA_000372685.1/#/def ), some genes that sounded attractive to explain the loss of vision ...
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The role of forkhead genes in eye development and disease
... Kume and colleagues demonstrated that the ch allele was caused by a mutation in Foxcl (a C—►T transition in the forkhead box) resulting in a truncated protein of 122 amino acids (compared to the normal 553aa). The ...
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Rab11 is required during Drosophila eye development
... The regulation of intercellular communication is essential for proper development and survival of all multicellular organisms. This communication is brought about by well coordinated protein transport mechanisms ...
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Mutations Modulating Raf Signaling in Drosophila Eye Development
... Rafkr”‘ phenotype. Clearly, not all genes involved in Raf signaling can be identified in such a screen. We did not, for instance, isolate any alleles of I)-MEK or poin[r] ...
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R8 development in the Drosophila eye: a paradigm for neural selection and differentiation
... As eye development occurs progressively, all stages of R8 specification are visualized ...(es) development but does occur during chordotonal organ (ch) ...
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Development and programed cell death in the mammalian eye
... in eye development The best-known genes involved in morphogenesis of the hu- man eyeball are Pax6 and Pax2 genes located on chromosome 11 and 10, ...for eye morphogenesis control” because it triggers ...
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Molecular Genetic Analysis of Drosophila eyes absent Mutants Reveals an Eye Enhancer Element
... normal eye development in Drosophila and is highly conserved to ...for eye function, we have defined the mutations in the four viable eya ...are eye specific and undergo transvection with ...
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VARIEGATION IN THE ZESTE EYE COLOR ALLELES AND ITS BEARING ON GENE ACTION DURING THE DEVELOPMENT OF THE EYE OF DROSOPHILA MELANOGASTER
... One principal difference between the action of the zeste alleles zm and z z and the action of the Lobe allele is, then, that the determination of red pigment for- mation i[r] ...
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Transcriptomic analysis of pluripotent stem cells: insights into health and disease
... The development of hiPSC technology offers the unique opportunity to derive disease-specific hiPSCs for the in vitro study of human disease pathogenesis (Figure ...
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Combined Extraskeletal Chondrosarcoma of Left Orbit : A Rare Second Primary Tumor of Retinoblastoma Survivor A Case Report
... rare eye malignant tumor of childhood, is generally responsive to chemotherapy or radiation therapy, but the survivors have high risk to development of second primary tumors (SPTs) due to genetic ...
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