Family based association test
Comparison of multilevel modeling and the family based association test for identifying genetic variants associated with systolic and diastolic blood pressure using Genetic Analysis Workshop 18 simulated data
... contrast, family-based association studies are particularly useful for identifying rare-variant ...in family-based genetic association ...longitudinal family-based ...
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Family based association test using normal approximation to gene dropping null distribution
... genome-wide association studies (GWAS) score test using 142 unrelated individuals, the family-based association test using FBAT [3], and the gene-dropping test on SNPs on ...
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Recommendations for using standardised phenotypes in genetic association studies
... for association with six obesity phenotypes: weight, BMI and BMI z-scores (BMIZ), 45 each with and without within- study ...the family-based association test (FBAT) statistic was used, ...
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A systematic review of CD14 and toll-like receptors in relation to asthma in Caucasian children
... FBAT: Family-Based Association Test, GEE: Generalized estimating equations, HWE: Hardy Weinberg Equilibrium, HPLC: High-Performance Liquid Chromatography, irt: in relation to, ISAAC: ...
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Implicit Hypotheses Are Hidden Power Droppers in Family Based Association Studies of Secondary Outcomes
... Desequilibrium Test (TDT) has emerged as the first popular family-based test of associa- tion (Spielman et ...any association between the genetic marker and the disease under ...complex ...
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On family based genome wide association studies with large pedigrees: observations and recommendations
... Family based association test: screening approach In addition to examining FBAT test statistics marginally, we also employed the Van Steen screening approach [19], which allows for a ...
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Comparing family based rare variant association tests for dichotomous phenotypes
... variant association methods for family-based samples using Genetic Analysis Workshop 19 (GAW19) simulated ...disequilibrium test (RV-TDT) [11], generalized estimating equations based ...
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Application of family based tests of association for rare variants to pathways
... consideration has been given to the performance of gene-based tests (typically designed for a smaller number of single-nucleotide variants [SNVs]) when the number of SNVs in the gene or in the pathway is very ...
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A combined association test for rare variants using family and case control data
... gene based on the 1000 Genomes project sequence data for the CEU (Utah residents with Northern and Western European ancestry) and MXL (Mexican ancestry in Los Angeles, California) populations, where each set ...
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Power Evaluations for Family-Based Tests of Association With Incomplete Parental Genotypes
... standardized test statistic Z, which is S standard- b, and the observed sib-recurrence risk ratios are as- ized by its conditional mean and variance given parental sumed to be 10 and 5 for the rare disease models ...
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Family based Bayesian collapsing method for rare variant association study
... genome-wide association studies (GWAS) as being associated with various complex diseases can account for only a small portion of pheno- type variation ...RV association because of their rare occur- ...
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Combining multiple family based association studies
... combined test (not ...bined test achieves a greater power than the probability that at least one of the two studies achieved statistical sig- nificance, even though the latter procedure has an inflated type ...
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An adaptive association test for microbiome data
... taxa based on the data. The proposed method is based on a generalized taxon pro- portion combining microbial abundance information with phylogenetic tree information and an adaptive test called the ...
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A comparative analysis of family based and population based association tests using whole genome sequence data
... both family-based and population-based designs, to detect association with variants in the MAP4 gene region and on chromosome 3 with blood ...the family-based association ...
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Pathway based analysis of rare and common variants to test for association with blood pressure
... Antonio Family Heart Study and San Antonio Family Diabetes/Gallbladder Study, which are supported by NIH grants P01 HL045222, R01 DK047482, and R01 ...
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A logistic mixture model for a family based association study
... of association between the trait and the diallelic marker was tested by fit- ting models with and without the diallelic marker as a covariate and then performing the likelihood-ratio test ...another ...
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A powerful microbiome-based association test and a microbial taxa discovery framework for comprehensive association mapping
... order, family, and genus) along with the dynamics of the entire microbial community complexity instead of enumerating individual ...for association testing [8, 9, 21–24]. The aggregate-based method ...
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A Powerful Nonparametric Statistical Framework for Family-Based Association Analyses
... For family-based association studies, the most widely adopted statistical method is the transmission disequilib- rium test (TDT) (Spielman et ...for family triads with dichotomous ...a ...
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Statistical Methods for Family-Based Association Studies for Complex Human Diseases: Single-Locus and Haplotype Methods
... haplotype test using the same disease models and family structures (data not ...a family, the haplotype of a male sibling determines one haplotype in the female ...haplotype test performance ...
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Lack of association of interferon regulatory factor 1 with severe malaria in affected child-parental trio studies across three african populations
... IRF family of transcription factors, which have key and diverse roles in the gene-regulatory networks of the immune ...to test whether genetic variation at the IRF1 locus also affects the risk of developing ...
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