Fatty acid binding proteins (FABPs) affinity and structure
Fatty acid binding proteins in brain development and disease
... polyunsaturated fatty acids (PUFAs) are critical structural components of the brain and essential for normal brain ...by fatty acid binding proteins (FABPs) which are encoded by the ...
11
Phyletic distribution of fatty acid-binding protein genes
... Abstract Fatty acid-binding proteins (FABPs) are a family of fatty acid-binding small proteins essential for lipid trafficking, energy storage and gene ...amino ...
9
Adipocyte/macrophage fatty acid–binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice
... adipocyte/macrophage fatty acid–binding proteins (FABPs) aP2 (FABP4) and mal1 (FABP5) to examine the contribution of these lipid chaperones in macrophages and adipocytes to local and systemic ...
12
Association of Free Fatty Acid (FFA), Fatty Acid Binding Protein (FABP) and Adiponectin with Tumor Necrosis Factor- (TNF- ) and
... cytoplasmic proteins that reversibly bind hydrophobic ligands such as saturated and unsaturated long chain fatty acids, plus eicosanoids such as hydroxyeicosatetraenoic acid, leukotrienes and ...
7
The human fatty acid-binding protein family: Evolutionary divergences and functions
... stoichiometry, affinity and specificity toward ...cytosolic proteins, due to the high concen- tration of FAs used for lipid biosynthesis, storage and ...
22
Exploring and Expanding the Fatty Acid Binding Protein superfamily in Fasciola species.
... those proteins consistently present on averaged gels and their putative protein identifications can be found in Table ...clade structure of FABP isoforms present in ...amino acid sequences through ...
48
Solution Structure and Backbone Dynamics of Human Liver Fatty Acid Binding Protein: Fatty Acid Binding Revisited
... Neither the ‘‘open-cap’’ conformation nor the ‘‘swivel- back’’ mechanism of K90 were found in the herein pre- sented human L-FABP solution structures or in any other known L-FABP or iLBP structure. Actually, the ...
10
Structure, Function, and Biosynthesis of Fatty Acid-Acylated Proteins
... Because fatty acylation is such a recently identified covalent modification, the characteristics of a protein that specify whether it becomes acylated, as well as the bios[r] ...
Heart fatty acid-binding proteins : role in cardiac fatty acid uptake and marker for cellular damage
... Heart fatty acid-binding proteins : role in cardiac fatty acid uptake and marker for cellular damage Citation for published version (APA): van Nieuwenhoven, ...Heart fatty ...
8
Identification of High Affinity Fatty Acid Binding Sites on Human Serum Albumin by MM-PBSA Method
... FA binding sites where large conformational changes can occur upon binding, the three trajectory method may be more accurate for calculation of binding free energy, than the single trajectory ...high ...
24
Affinity Profiles Categorize RNA-Binding Proteins into Distinctive Groups
... Our binding assays have effectively demonstrated that RBPs have distinctive subgroups classified with criteria of their binding affinity [28, ...RNA binding assays [28, 29, ...mild ...
8
Probing the DNA-Binding Affinity and Specificity of Designed Zinc Finger Proteins
... signed proteins in vitro to correlate their DNA-binding prop- erties with any potential biological ...nucleic acid target are free in solution ( 38–40 ...a binding isotherm from which the ...
9
An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance
... intestinal fatty acid binding protein locus (FABP2) was investigated as a possible genetic factor in determining insulin action in the Pima Indian ...greater affinity for long-chain ...
8
Microbial fatty acid transport proteins and their biotechnological potential
... of fatty acids through membrane is only lately being put into question, the study of fatty acid transport systems during the last years has shed light on several of these systems and their mechanism ...
25
Fatty acid binding protein Role in esterification of absorbed long chain fatty acid in rat intestine
... https://doi.org/10.1172/JCI108510. Fatty acid binding protein (FABP) is a protein of 12,000 mol wt found in cytosol of intestinal mucosa and other tissues, which exhibits high affinity for ...
11
Specificity and Affinity of Sialic Acid Binding by the Rhesus Rotavirus VP8* Core
... the binding site, but their backbone amides are posi- tioned close to several aromatic rings so that small binding- induced movements may significantly change their electronic ...sialoside binding ...
6
Studies on the binding affinity of anticancer drug mitoxantrone to chromatin, DNA and histone proteins
... matin structure with higher affinity than free ...The binding of mitoxantrone to chromatin produces a very compact structure that prevents the release or extraction of histone proteins ...
7
Ligand binding properties of two Brugia malayi fatty acid and retinol (FAR) binding proteins and their vaccine efficacies against challenge infection in gerbils
... FAR proteins for metabolic needs, and their potential roles in development and immune modulation of the host makes them per- tinent targets for anthelmintic drugs and vaccine ...FAR proteins from ...ligand ...
20
Study and engineering of nucleic acid-binding repeat proteins
... TALE proteins sample the DNA sequence by one-‐dimensional diffusion, which is achieved by a combination of hopping and sliding ...co-‐crystal structure of a TALE with noncognate DNA would be helpful in ...
182
Protein function prediction by integrating sequence, structure and binding affinity information
... Most available tools for prioritizing genetic variants are however limited to non-synonymous SNVs. Examples are SIFT [ 235 ] , POLYPHEN [ 236 ] , and MutPred [ 237 ] (for recent reviews, see [ 238 – 241 ]). These tools ...
196