fatty acid synthase gene
Trans chalcone and quercetin down regulate fatty acid synthase gene expression and reduce ergosterol content in the human pathogenic dermatophyte Trichophyton rubrum
... Quercetin and trans-chalcone presented the best anti- fungal activity among the flavonoids tested. The results of the FAS enzymatic assay showed that quercetin is a better inhibitor of this enzyme than trans-chalcone. ...
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Effects of olive oil polyphenols on fatty acid synthase gene expression and activity in human colorectal cancer cells
... Real-Time PCR was carried out with iCycler Thermal Cycler System apparatus (Bio-Rad) using the following parameters: 1 cycle of 95°C for 1 min and 30 s, followed by 45 cycles at 94°C for 10 s, 55°C for 10 s and 72°C for ...
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Gene expression profiles of aralkylamine n-acetyltransferase, b-cell translocation gene-2 and fatty acid synthase in pasture-based primiparous Holstein-Friesian dairy cows supplemented with crude degummed canola oil
... Understanding the mechanism underpinning the impact of dietary fat intake on the reproductive sequences from oestrous to conception in cows could revolutionise how nutrition is managed in dairy farms to improve ...
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Evaluation of Circulating Fatty Acid Synthase as a Biomarker in Non Alcoholic Fatty Liver Disease
... Fatty-acid synthase (FAS) (EC ...FAS gene expression and enzymatic activity are primarily regulated by metabolic sig- nals in the liver ...
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Original Article Cerulenin induces apoptosis in hepatic cancer HepG2 cells in vitro and in vivo
... Endogenous fatty acids are consid- ered to be important sources of fatty acids which are required for tumor cell ...the fatty acid metabolism of tumor cells depends on fatty acid ...
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Involvement of fatty acid synthase in dengue virus infection
... DENV 2 infection of FASN silenced HEK293T/17 cells The modulation of lipid metabolism associated gene ex- pression during DENV infection suggests that this process might be a suitable anti-DENV target. To ex- ...
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Increasing medium chain fatty acids production in Yarrowia lipolytica by metabolic engineering
... Cellular fatty acids are derived from three different sources: endogenous lipid turnover, de novo synthesis and elongation, and external ...solic fatty acid synthase (FAS) catalyzes de novo ...
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AMPK -1 , and lower APOB gene expression in the liver than 42-day-old broilers. Age had no effect on FAS gene expression. Our results show that the gender and age could act on the expression of genes related to
... of fatty acid synthase (FAS), apolipoprotein A-I (APOA-I), apolipoprotein B (APOB), adiponectin (ADIPOQ), liver kinase B1 (LKB1), and AMP-activated protein kinase α-1 (AMPKα-1) genes was evaluated by ...
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Effect of cerulenin on fatty acid composition and gene expression pattern of DHA-producing strain Colwellia psychrerythraea strain 34H
... conventional fatty acid desaturase/ elongase pathway in algae and ...20 fatty acid desaturases and fatty acid elongases involved in this process ...polyketide synthase ...
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Impact of dietary protein on lipid metabolism-related gene expression in porcine adipose tissue
... free fatty acid and triglyceride concentrations in the HP group were significantly higher than in the LP ...reduced gene expression of acetyl CoA carboxylase (ACC), fatty acid ...
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Fatty Acid Synthase Inhibitor C75 Ameliorates Experimental Colitis
... active molecules (7). Free or unesterified FAs are ubiquitous in all living tissues and are unbound to other molecules (es- pecially albumin) (7). Recently, free FA has emerged as an important component in transmitting ...
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Polyunsaturated fatty acids reduce Fatty Acid Synthase and Hydroxy-Methyl-Glutaryl CoA-Reductase gene expression and promote apoptosis in HepG2 cell line
... metabolic manipulation. In addition to chemically synthesized compounds, much effort has been directed to identifying endogenous mechanisms of tumor sup- pression and, by high-throughput screening, of antican- cer ...
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Vol. 2, Issue 10, October 2013
... that fatty acid synthase and glycerol-3-phosphate dehydrogenase shared the most identity with each ...in fatty acid synthase and glycerol-3- phosphate ...In fatty ...
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Transcriptome and gene expression analysis of docosahexaenoic acid producer Schizochytrium sp. under different oxygen supply conditions
... for fatty acid biosynthesis in Schizochytrium sp., a fatty acid synthase (FAS) pathway, and a polyunsaturated fatty acid synthase pathway (PKS) ...saturated ...
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High quality draft genome sequence of Corynebacterium ulceribovis type strain IMMIB-L1395T (DSM 45146T)
... polyketide synthase [64, 65]; pks13 encoding for a polyketide synthase (A3ECDRAFT_1932) that performs the condensation of two fatty acids to form a 2-alkyl-3- keto mycolate precursor [66]; elrF ...
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Metabolic engineering of microbes for branched-chain biodiesel production with low-temperature property
... total fatty acid ester production ...amino acid biosynthesis is another reason for the high proportion of FABCEs because these genes lead to the accumulation of a large amount of branched- chain ...
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Brain fatty acid synthase activates PPARα to maintain energy homeostasis
... how fatty acids, malonyl-CoA, and other metabolites act at this site to alter metabolism is poorly ...of fatty acid synthase (FAS), rate limiting for de novo lipogenesis, decreases appetite ...
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Inhibitory effects of grape skin extract and resveratrol on fatty acid synthase
... six enzymatic active sites, which are acetyl/malonyl trans- ferase, β-ketoacyl synthase, β-ketoacyl reductase (KR), β- hydroxyacyl dehydratase, enoyl reductase, and thioesterase [15]. FAS is over-transcripted and ...
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Dietary saponins of sea cucumber alleviate orotic acid-induced fatty liver in rats via PPARα and SREBP-1c signaling
... in fatty acid biosynthesis and ...alters gene expression of hepatic lipids meta- bolism, sterol-regulatory element binding protein (SREBP-1c) mRNA, the principal regulator of hepatic fatty ...
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Fatty Acid Synthase Promotes the Palmitoylation of Chikungunya Virus nsP1
... Protein palmitoylation is mediated by PATs and protein thioesterases (16). In our study, ZDHHC2 and ZDHHC19 are the major PATs for nsP1. By associating with nsP1, ZDHHC2 and ZDHHC19 promoted the palmitoylation of nsP1. ...
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