Fitness Landscape
Fitness Landscape of Human Immunodeficiency Virus Type 1 Protease Quasispecies
... the fitness of the virus ...phylogenetic-fitness landscape map shows that some of these low-fitness variants were not generated by single mutations from the master se- quence or fitter ...
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Statistical Models of the Protein Fitness Landscape: Applications to Protein Evolution and Engineering
... a fitness landscape in protein sequence space and use this framework to explain directed evolution ...this fitness landscape and the types of trajectories that can traverse it ...This ...
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A model for viral assembly around an explicit RNA sequence generates an Implicit fitness landscape
... the fitness landscape. To illustrate the two- dimensional landscape, a pair of mutations are selected and their effect on the assembly yield are shown using bar ...the fitness landscape ...
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Evolution of the genetic code: partial optimization of a random code for robustness to translation error in a rugged fitness landscape
... the fitness landscape, a simple evolutionary algorithm, with elementary evolutionary steps comprising swaps of four-codon or two-codon series, was employed to investigate the optimization of codes for the ...
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The fitness landscape of the African salmonella typhimurium ST313 strain D23580 reveals unique properties of the pBT1 plasmid
... the fitness landscape of the African Salmonella enterica serovar Typhimurium ST313 strain D23580, to complement our previous comparative genomic and functional transcriptomic ...for fitness under two ...
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Fitness landscape and tax planning: NK model for fiscal federalism
... the fitness landscape and the NK model of Kauffman (1993) as tools used to analyze the evolutionary dynamics of complex systems and we stress the use of such tools in ...a landscape in which ...
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Effect of Host Species on Topography of the Fitness Landscape for a Plant RNA Virus
... Adaptive fitness landscapes are a fundamental concept in evolutionary biology that relate the genotypes of individuals to their ...the landscape, that is, the num- bers of accessible mutational pathways and ...
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Gene fitness landscape of group A streptococcus during necrotizing myositis
... GAS fitness in human saliva and blood ex vivo and mouse subcutaneous ...M1 fitness in both human saliva and NHP necrotizing myositis (Figure ...with fitness genes required ex vivo in human ...
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Exploring the Fitness Landscape of an RNA Virus by Using a Universal Barcode Microarray
... about fitness and genetic variation within complex populations ...viral fitness closely mirrored those derived from the viral titer and quantitated the fitness of a large number of mutants ...
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Evolutionary Rescue over a Fitness Landscape
... evolution of resistance, whereby some (portions or sets of) genes contribute most of the resistance mutations, is often observed among drug-resistance alleles, and can increase with stress (Harmand et al. 2017), contrary ...
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Stickbreaking: A Novel Fitness Landscape Model That Harbors Epistasis and Is Consistent with Commonly Observed Patterns of Adaptive Evolution
... Simulations written in R (R Development Core Team 2009) were used to study the patterns of fitness trajectory, distri- bution of fitness effects, and epistasis and to compare these to the theoretical results derived above. ...
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Fitness Landscape of the Fission Yeast Genome
... In theory, functionally important elements could be detected by their conservation between lineages relative to neutral elements. However, such analyses suffer from the par- adox that more divergent species allow more ...
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Developmental Associations Between Traits: Covariance and Beyond
... the fitness landscape is over the space As shown in Rice (1998), stabilizing selection on trait of underlying factors, rather than over the space of φ 1 should, all else held equal, move the population ...
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On crossing fitness valleys with the Baldwin Effect
... on fitness landscape made by mate choice, allowing populations to move into new adaptive zones; and genetic operators such as sexual recombination that allow large non-random genetic changes by crossing ...
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Perspective:Sign Epistasis and Genetic Constraint on Evolutionary Trajectories
... higher fitness genotypes differing by mutations at multiple ...the fitness landscape because no mutational trajectory ...increase fitness (but see Carter and Wagner 2002; Iwasa et ...the ...
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Conflict between heterozygote advantage and hybrid incompatibility in haplodiploids (and sex chromosomes)
... Parental P+ genotype Introgressed P+ genotype Introgressed P- genotype Parental P- genotype Heterozygous hybrid A+ B- homozygous hybrid A- B+ homozygous hybrid a Fitness Landscape for Di[r] ...
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A comparison of neutral landscapes NK, NKp and NKq
... to fitness) is therefore a many to one mapping and there arises the possibility of neutral mutations between genotypes of equal fitness occurring in the absence of selective ...resulting fitness ...
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msz022.pdf
... experimental fitness landscape of all individual amino acid changes in ...experimental fitness, indicating that the experimental fitness landscape captured key features of selection ...
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The Rank Ordering of Genotypic Fitness Values Predicts Genetic Constraint on Natural Selection on Landscapes Lacking Sign Epistasis
... that fitness interactions between alleles at different loci, also called epistasis for fitness, could constrain evolution by natural selection since alleles may not confer an equal fitness effect in ...
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Rugged NK landscapes contain the highest peaks
... sulting fitness landscape is smooth, containing only a single ...the landscape lie in the basin of attraction of the global optimum, making it triv- ially easy to ...resulting landscape ...
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