free light chains
Removal of free light chains in hemodialysis patients without multiple myeloma: a crossover comparison of three different dialyzers
... of free light chains and β2M in chronic dialysis patients not af- fected by multiple ...removing free light chains, while HFR17 proved more effective in the removal of β2M ...k/l ...
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The difference of free light chains as a predictor of kidney damage in patients with Multiple Myeloma
... 16. Hutchison, C.A., Stephen Harding, Pete Hewins, et al., Quantitative assessment of serum and urinary polyclonal free light chains in patients with chronic kidney disease. Clinical journal of the ...
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Diagnostic and mechanistic implications of serum free light chains, albumin and alpha-fetoprotein in hepatocellular carcinoma
... In a search for an alternative or additional serum markers for HCC, we and others (Poon et al, 2003; Schwegler et al, 2005; Ward et al, 2006b) have used surface-enhanced laser desorption/ ionisation (SELDI) mass ...
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Novel renal replacement strategies for the elimination of serum free light chains in patients with kappa light chain nephropathy
... eliminate free light chains from circulating blood, however the effi- cacy was poor with older ...serum free light chain (sFLC) using a newly designed protein leaking membrane in ...
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Free light chains: potential biomarker and predictor of mortality in alpha-1-antitrypsin deficiency and usual COPD
... of free light chains (FLCs) produced which are secreted into the circulation before undergoing renal clearance ...two free light chain isotypes: kappa (κ) and lambda (λ), which can be ...
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Relationship between circulating syndecan-1 levels (CD138s) and serum free light chains in monoclonal gammopathies
... globulin light chains must exit cells in order to circulate freely: in this context, it is of great interest to consider the role of CD138 involved in exosome biogenesis, as these cargo containing vesicles ...
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A hereditary immunoglobulin A abnormality: absence of light heavy—chain assembly: Study of immunoglobulin synthesis in tonsillar cells
... and light-chain, was found in an adult female suffering from recurrent upper respiratory infection and tonsillitis since childhood, but otherwise ...of free a-chains, in her saliva by the presence of ...
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Polyclonal light chains in cerebrovascular disease
... polyclonal free light chains, their predic- tive role concerning short- and long-term prognosis, and the association with cardiac and renal echographic and magnetic resonance imaging parameters are ...
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Immunoglobulin light chains generate proinflammatory and profibrotic kidney injury
... chronic kidney disease has drawn attention in the treatment of multiple myeloma, a malignant hematologic disorder that can produce significant amounts of monoclonal immunoglobulin free light chains ...
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Key words
... for solubilizing the amyloid fibril is not known at the moment. The response criteria in patients with amyloidosis AL meet both the monoclonal pro- tein, measured as a serum free light chains level, ...
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Key words
... Background. AL amyloidosis is an acquired systemic disease in which a pathologic amorphous substance pro- duced as a result of abnormal protein metabolism is deposited in the extracellular space of various tissues. ...
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Comparability Assessments of Process Changes Made during Development of Anti Idiotype Vaccine
... and/or light chain sequences begin with ...and light chains of many MAbs codes for an N-terminal glutamine, but upon sequencing the N-terminal amino acid is predominantly found as the cyclized ...
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Amyloid Goiter: Clinicopathological Assessment of Two Cases and Review of Literature
... (amyloid light chain) found in pri- mary amyloidosis is derived from plasma cells and contains immunoglobulin light chains; 2) AA (amyloid-asso- ciated) found in secondary amyloidosis is a unique ...
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Development and characterization of polyclonal antibody against human kappa light chain in rabbit
... Human immunoglobulin G (IgG) purification. Blood samples were taken from patients referred to the Imam Reza Hospital (Tabriz, Iran) with their informed consent (No. TBZMED.REC.1394.457). Peripheral blood samples were ...
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Inconclusive flow cytometric surface light chain results; can cytoplasmic light chains, Bcl-2 expression and PCR clonality analysis improve accuracy of cytological diagnoses in B-cell lymphomas?
... With the use of molecular test our detection rate of BCL was lower than reported by EuroClonality/BIOMED- 2 group where clonal IGH-gene rearrangement was found in 91 % of BCL [29]. The frequency of monoclonal B cell ...
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Clinical responses with T lymphocytes targeting malignancy associated κ light chains
... κ light chain of human Ig produced by the CRL-1758 mouse hybri- doma (ATCC) as a single chain (scFv) and generated a second-gener- ation CAR construct containing both CD28 and ζ endodomains ...
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ADVANCED ERROR RECOVERY FOR TMR SYSTEMS
... To address the issue of transient error, an error recovery technique should be employed along with the TMR technique. That is the TMR is modified to include a controller, which is the brain of the system. The working of ...
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Elucidating the role of free polycationic chains in polycation gene carriers by free chains of polyethylenimine or <em>N,N,N</em>-trimethyl chitosan plus a certain polyplex
... cific. Thus, the free polycationic chains can interact with the proteins in the membrane of the early endosomes, late endosomes, lysosomes, or other organelles. In the presence of bafilomycin, the proton ...
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From Diffusion of Light to Free Form Scattering
... In this chapter, first an overview is given of all possible interactions between a photon and a scattering medium in sections 2.1 and 2.2. In section 2.3 the radiative transfer equation is shown, which describes the ...
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Original Article Plasma cell myeloma with dual expression of kappa and lambda light chains
... light chain study revealed increased kappa free light chain (294.9 mg/l; reference range 3.3- 19.4 mg/l) and normal lambda free light chain (20.8 mg/l; reference range 5.7-26.3 mg/l) ...
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