Function of Gap Junctions and Hemi-channels
The stage-specific function of gap junctions during tumourigenesis
... of gap junctional coupling and the invasive potential of blood and tumour cells including their penetration through the endothelium seems well documented, the molecular mediators of these processes remain ...and ...
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Sex differences in endothelial function in porcine coronary arteries: a role for H2O2and gap junctions?
... of gap junctional commu- nication in male and female arteries as it has been reported that gap junctions play a role in the EDH-mediated ...that gap junctional communication did not play a ...
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Conduction abnormalities and ventricular arrhythmogenesis: The roles of sodium channels and gap junctions
... 3. Sodium channels Voltage-gated sodium channels are responsible for the initiation and propagation of APs in excitable cells. Each channel consists of a pore-forming α-subunit, a modulatory β-subunit and ...
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Conduction abnormalities and ventricular arrhythmogenesis: The roles of sodium channels and gap junctions
... 3. Sodium channels Voltage-gated sodium channels are responsible for the initiation and propagation of APs in excitable cells. Each channel consists of a pore-forming α-subunit, a modulatory β-subunit and ...
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Conduction abnormalities and ventricular arrhythmogenesis: The roles of sodium channels and gap junctions
... 3. Sodium channels Voltage-gated sodium channels are responsible for the initiation and propagation of APs in excitable cells. Each channel consists of a pore-forming α-subunit, a modulatory β-subunit and ...
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Gap Junctions and NCA Cation Channels Are Critical for Developmentally Timed Sleep and Arousal in Caenorhabditis elegans
... innexin function dramatically reduced sleep and decreased arousal threshold during developmentally timed sleep in Caenorhabditis ...UNC-7 function was required in premotor interneurons and UNC-9 ...
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Engineered connexin40 variants increased docking and function of heterotypic connexin40/connexin43 gap junction channels
... 3.5 Future studies My study assessed if the artificial D55N and P193Q mutations formed functional gap junctions using connexin-deficient neuroblastoma cells (N2A). This study was limited by the use of only ...
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Gap junctions, dendrites and resonances : a recipe for tuning network dynamics
... Each gap junction contains numerous connexon hemi-channels, which cross the membranes of both ...a gap junction channel is wide enough to allow ions and even medium-sized signalling molecules ...
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The role of gap junctions in the excitability of the myometrial smooth muscle network
... activation of potassium. The kinetics of the variables give rise to the fast activation and slow repolarisation of the cell which is observed in vivo. 1.10.2 FitzHugh-Nagumo model In this thesis, we use the FHN ...
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Gap junctions modulate glioma invasion by direct transfer of microRNA
... the gap junction mediated effects we have shown, given the combined specificity provided by the three methods used to address gap junction ...when gap junctions were ...
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Gap Junctions, Dendrites and Resonances: A Recipe for Tuning Network Dynamics
... Each gap junction contains numerous connexon hemi-channels, which cross the membranes of both ...a gap junction channel is wide enough to allow ions and even medium-sized signalling molecules ...
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Osmotic Forces and Gap Junctions in Spreading Depression: A Computational Model
... its physiological range while holding all other conduc- tances fixed. Decreasing the conductance corresponds to simulation of channel block and increasing the con- ductance corresponds to simulation of channel over- ...
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Targeting neuronal gap junctions in mouse retina offers neuroprotection in glaucoma
... tal glaucoma, we found that genetic ablation of Cx36 produced significant protection of retina structure and function. Interest- ingly, ablation of both Cx36 and Cx45, which are expressed by most, if not all, GJs ...
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A role for heterologous gap junctions between melanoma and endothelial cells in metastasis
... heterologous gap junction between melanoma and endothelial cells in spontaneous ...may function during the process of intrava- sation around the primary ...
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Neuronal networks with gap junctions: A study of piece wise linear planar neuron models
... Next, in section 3, we show how to analyze periodic orbits that arise in such models under constant current injection. This includes the construction of orbits, the determination of their stability, and the calculation ...
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Gap junctions in Malpighian tubules of Aedes aegypti
... through gap junctions to be ...average gap-junction resistance ( R gj ) of 431·k between two ...open gap-junctional channels, assuming the high single gap-junction conductance of ...
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Differential regulation of gap junctions by proinflammatory mediators in vitro
... myoendothelial gap junction channels studied here consist of ( a ) solely Cx43, ( b ) solely Cx40, or ( c ) mixtures of Cx37 and either Cx43 or Cx40, in which the two connexons are constructed entirely of ...
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The molecular organization and function of paranodal septate junctions
... paranodal junctions not only are distinct in their structural components as clearly stated with the Nogo-A protein but there could be also differences in their functions throughout the nervous ...axo-glial ...
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The biochemistry and function of pannexin channels
... of gap junction pro- ...of gap junction proteins with similar tetra-spanning topologies but very di- verse ...intercellular gap junction channels, the vast majority of the literature supports ...
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The effect of a secondary task on drivers’ gap acceptance and situational awareness at junctions
... gumbel function, with the mean of the posterior distri- bution being updated on a trial by trial basis using a Palamedes MATLAB script (Kingdom and Prins 2010) and this was used to provide estimates of the ...
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