G -binding specificity profiles and mutational analysis
Presentation Overrides Specificity: Probing the Plasticity of Alphaviral Proteolytic Activity through Mutational Analysis
... apparent specificity of viral enzymes makes them attractive targets for antiviral ...improved specificity and affinity, whereas estimating the ex- tent of the plasticity of enzyme functionality may allow ...
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High-resolution DNA-binding specificity analysis of yeast transcription factors
... TF binding sites by microarray readout of chromatin im- munoprecipitation (ChIP-chip), nearly half of all known yeast TFs are of unknown DNA-binding specificities, and many additional predicted TFs remain ...
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DNA-binding sequence specificity of DUX4
... middle G which deviates from the consensus) because a number of DUX4 targets have ChIP-seq peaks in nearby MaLR elements [11, ...DUX4 binding is unknown, therefore, with the exception of the second and ...
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Heterogeneity of genomic evolution and mutational profiles in multiple myeloma
... (w mis ¼ 1, w non ¼ 1 or w splice ¼ 1). Since the limited number of mutations per gene prevents the estimation of different rates per gene, mutation rates were assumed constant among genes and only the three selection ...
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Mutational and Metal Binding Analysis of the Endonuclease Domain of the Influenza Virus Polymerase PA Subunit
... fragments cleaved from cellular (pre-)mRNAs. Two activities are required for this cap-snatching activity: specific binding of the cap structure and an endonuclease activity. Recent work has shown that the ...
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Ligand Specificity of Brain Lipid-binding Protein*
... function analysis of the BLBP binding pockets to identify a physiological ligand for ...the binding specificity of BLBP to common fatty acids is different than that of other FABPs, since it ...
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Mutational profiles of persistent/recurrent laryngeal squamous cell carcinoma
... Analysis of primary LSCC specimens in recent whole- exome sequencing (WES) studies by Stransky et al. (n = 15) 9 and the Cancer Genome Atlas Network (n = 117) 10 has identi- fied high rates of TP53 mutations, ...
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Modeling the Quantitative Specificity of DNA-Binding Proteins from Example Binding Sites
... determine binding models based on sets of example binding ...in-depth analysis of just this one ...the binding specificity has been well characterized ...symmetric binding site ...
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Distinct profiles of immunoglobulin G-binding-protein expression by invasive serotype M1 isolates of Streptococcus pyogenes.
... IgG-binding-protein profiles may provide an additional marker that can be used to identify variations among M1 isolates that might, in concert with other putative virulence markers, help to identify sub- ...
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PDZ domains and their binding partners: structure, specificity, and modification
... be binding partners for the Dvl PDZ domain ...their binding partners is key to understanding their biological ...proposed binding partners by other ...PDZ binding partners reported by Tonikian ...
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Differential immune profiles distinguish the mutational subtypes of gastrointestinal stromal tumor
... these findings suggest that CXCL14 expression may contribute to the observed differences in immune infiltration between PDG- FRA- and KIT-mutant GISTs (31, 32). PDGFRA mutation produces multiple HLA-diverse, strong bind- ...
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Mutational Analysis of the Binding Pockets of the Diketo Acid Inhibitor L-742,001 in the Influenza Virus PA Endonuclease
... proposed binding mode of the endonuclease inhibitors in the con- text of the entire viral polymerase complex, as present in influenza virus-infected ...in binding and anti- viral activity of L-742,001, here ...
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Mutational analysis of a proposed structural element in the SRP9/14p binding site of Schizosaccharomyces pombe SRP RNA
... pentanucleotide hairpin loop near the 5' end o f the SRP RNA and a second substitution in the .1' side o f the stem (see figure 1). As noted in the Introduction, this region o f S. pom be SRP RNA corresponds to the ...
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Structural Analysis of Determinants of Histo-Blood Group Antigen Binding Specificity in Genogroup I Noroviruses
... Conclusion. Recent epidemiological studies have shown in- creased prevalence of GI NoVs. Although secretor-positive status is strongly correlated with NoV infection, cases of NoV infection associated with ...
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Binding specificity and affinity analysis of an anti protective antigen peptide reagent using capillary electrophoresis
... analyte binding association (K b ) and dissociation constants (K d ...peptide specificity of an isolated peptide binding reagent to protective antigen (PA) of Bacillus anthracis were evaluated us- ...
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Transient expression and mutational analysis of the rotavirus intracellular receptor: the C-terminal methionine residue is essential for ligand binding.
... Use of the T7-vaccinia virus transient expression system to deliver a range of mutant forms of NS28 has provided further evidence that this protein acts as the intracellular receptor for[r] ...
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Estimating binding properties of transcription factors from genome-wide binding profiles
... low binding, in addition to the reduction in the cor- relation we also observed a decrease in the mean squared error, which is statistically significant in the case of Bicoid, Caudal and Kruppel; see Supplementary ...
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The clinical trial landscape in oncology and connectivity of somatic mutational profiles to targeted therapies
... Sara E. Patterson, Rangjiao Liu, Cara M. Statz, Daniel Durkin, Anuradha Lakshminarayana and Susan M. Mockus * Abstract Background: Precision medicine in oncology relies on rapid associations between patient-specific ...
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Adamantinomatous and papillary craniopharyngiomas are characterized by distinct epigenomic as well as mutational and transcriptomic profiles
... adamantinomatous (adaCP) and papillary CP (papCP), were previously identified based on histomorphological and epidemiological aspects. Recent data indicates that both variants are defined by specific genetic alterations, ...
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Quantifying the effects of mutations on receptor binding specificity of influenza viruses
... to binding preference asured the ISM. Our numerical analysis implied that the mutations in HA1 of 2009 hu- man H1N1 collectively tended to reduce the swine binding affinity in the seasonal H1N1 ...
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