Genome instability and mutation
A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility
... A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility Jennifer L. Shepard* † , James F. Amatruda* †‡ , Howard M. Stern* § , Aravind Subramanian ¶ , David ...
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Telomeres in cancer: tumour suppression and genome instability
... Anaphase bridges RPA Figure 5 | Chromothripsis and kataegis in telomere crisis. a | Dicentric chromosomes formed by telomere fusion rarely, if ever, break during mitosis and instead form chromatin bridges. b | Daughter ...
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DNMTs are required for delayed genome instability caused by radiation
... spontaneous mutation rates. However, the high de novo mutation rate of Dnmt1 -/- mESCs was further demonstrated by the occurrence of second mutation events during expansion of the ...
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Neoantigens and genome instability: impact on immunogenomic phenotypes and immunotherapy response
... genomic instability occurs in POLE- or POLD1-mutated cancers, where the levels of mutational burden (based on SNVs) in POLE exonuclease domain mutated cancers are extremely ...POLE-driven genome instabil- ...
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CiteSeerX — SURVEY AND SUMMARY DNA replication stress, genome instability and aging
... Reduced expression of Mcm2 in mice homozygous for this mutation does not impact normal development. However, beginning at 9 weeks of age, these mice exhibit a constellation of aging phenotypes, including the ...
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Pif1 family helicases suppress genome instability at G-quadruplex motifs.
... events were usually associated with mutation of the G4 insert so that it could no longer form a G4 structure (Fig. 4a), suggesting that the process enabling cells to replicate and/or repair a G4 motif in the ...
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Genome Instability Is Promoted by the Chromatin-Binding Protein Spn1 in Saccharomyces cerevisiae
... in genome in- stability in Saccharomyces ...damage-induced mutation rates, and increased chronological ...promoting genome insta- bility by influencing DDT subpathway ...
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Chromatin loop anchors are associated with genome instability in cancer and recombination hotspots in the germline
... on mutation rates in each of the nine tumour types separately, using, as input features, only cell type-invariant features around the union set of 14,737 LAPs (Additional file 1: Table ...between mutation ...
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Induction of endocycles represses apoptosis independently of differentiation and predisposes cells to genome instability
... 1997). Mutation in the Apc2 ubiquitin ligase subunit called morula, or the Cyclin A translational repressor arrest, increases mitotic cyclin levels in these nurse cells and results in an inappropriate mitosis in ...
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Elevated Genome-Wide Instability in Yeast Mutants Lacking RNase H Activity
... to genome instability: the formation of R-loops during transcription and the incorporation of ribonucleotide monophosphates (rNMPs) into DNA during ...yeast genome in diploid strains of Saccharomyces ...
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A novel mechanism inducing genome instability in Kaposi's sarcoma-associated herpesvirus infected cells.
... tumours. Genome instability is an enabling characteristic that allows the progression of tumorigenesis through genetic mutation and therefore, understanding the mo- lecular causes of genome ...
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Whole genome doubling propagates chromosomal instability and accelerates cancer genome evolution
... Chapter 6. Results 4: A screen for regulators of cell cycle re-entry after cytokinesis failure 6.1 Introduction In Chapter 5 the functional consequences of tetraploidy in the isogenic system of clones derived from ...
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Med12 gain of function mutation causes leiomyomas and genomic instability
... aCGH of Med12 c.131G>A mouse uteri not only revealed genome-wide aberrations, but also showed complex chromoso- mal alterations such as chromothripsis. Recently, chromothripsis was reported in human leiomyomas and ...
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HorkaD, a Chromosome Instability-Causing Mutation in Drosophila, Is a Dominant-Negative Allele of lodestar
... transplantation were mated with appropriate partners, as de- scribed in Tables 2 and 3, and tested for germ-line chimerism. Inverse PCR: To clone the Horka D -identified gene, we used the inverse PCR technique and ...
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Genomes on the Edge: Programmed Genome Instability in Ciliates
... hypothesis is that they help introduce DNA cleavage, and this would be congruent with the step of RNA-directed DNA synthesis in the RNA template model discussed above. Furthermore, because piRNAs traditionally suppress ...
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Pathways and Mechanisms that Prevent Genome Instability in Saccharomyces cerevisiae
... ABSTRACT Genome rearrangements result in mutations that underlie many human diseases, and ongoing genome instability likely contributes to the development of many ...studying genome ...
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BAF180 Promotes Cohesion and Prevents Genome Instability and Aneuploidy
... We first determined whether BAF180 influences aneuploidy by analyzing chromosome spreads prepared from BAF180 / mESCs, and found that they had an increased average number of chromosomes per cell when compared with WT ( ...
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Correlation Between Mutation Rate and Genome Size in Riboviruses: Mutation Rate of Bacteriophage Qβ
... any mutation in the UAG codon and 2/48 plaques showed mutations at other sites (T1431C and C1213T, both ...fore, mutation frequency does not seem to depend on whether amber mutants or revertants were ...a ...
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Premeiotic and Meiotic Instability Generates Numerous b2 Mutation Derivatives in Ascobolus
... The unique allele GO is unstable both in crosses to wild-type and in self-crosses, giving rise to three dif- ferent types of derivative products: the GI (white, stable) d[r] ...
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Conditional Coalescent Trees With Two Mutation Rates and Their Application to Genomic Instability
... (genomic instability) during tumor progression, with the initiation of abnormal mutation rates caused by the loss of mismatch ...of mutation in tumor cells with the aim of estimating the amount of ...
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