GPCR, G protein-coupled receptor
Identification and Characterization of Novel Variations in Platelet G-Protein Coupled Receptor (GPCR) Genes in Patients Historically Diagnosed with Type 1 von Willebrand Disease
... the GPCR genes directly in the ...the GPCR SNVs identified in the study using heterologous expression ...on receptor expression or function which are not easily detected after overexpression in ...
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Identification and characterization of novel variations in platelet G-protein coupled receptor (GPCR) genes in patients historically diagnosed with type 1 von Willebrand disease : GPCR variations in type 1 von Willebrand disease
... the GPCR genes directly in the ...the GPCR SNVs identified in the study using heterologous expression ...on receptor expression or function which are not easily detected after overexpression in ...
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Modulation of G Protein-Coupled Receptor Intracellular Trafficking and Signal Transduction
... factor receptor 1, somatostatin-3 receptor, vasopressin V2 receptor, neurokinin-1 receptor, chemokine CXC receptor-2, m4 muscarinic acetylcholine receptor and protease ...
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G Protein Coupled Receptor Allosterism.pdf
... modify protein-protein ...coat protein gp120, the cellular single transmembrane protein CD4, and the chemokine GPCR ...CCR5 receptor (blockade of which is not amenable to ...
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Regulation of bone formation and remodeling by G protein coupled receptor 48
... orphan GPCR, Gpr48, regulates bone formation and remodeling by promoting osteoblast differentiation and ...this GPCR can regulate bone formation and remodeling and that it could be a potential therapeutic ...
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Functional characterisation of the Anopheles leucokinins and their cognate G protein coupled receptor
... neurohormone receptor-like-encoding sequences were also identified in a survey of the GPCR repertoire of the Anopheles genome (Hill et ...a receptor for Anopheles ...
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Complete reversible refolding of a G-protein coupled receptor on a solid support
... membrane protein folding in vivo ...numerous G protein subtypes as well as through G-protein independent pathways, often in a ligand-specific manner [13, ...particular protein ...
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The Role of G Protein-coupled Receptor Kinases in Cancer
... in GPCR desensitization ...during GPCR desensitization was shown in vitro and in ...GRKs, GPCR receptor desensitization was greatly minimized ...β-adrenergic receptor, and subsequent ...
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Role of Conformational Changes in G Protein-Coupled Receptor Activation
... Most receptor structural prediction programs rely on homology modeling where the GPCR crystal structure’s sequence is modified to match that of the target ...CB1 receptor, it had a sequence identity ...
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G-protein coupled receptor expression patterns delineate medulloblastoma subgroups
... a GPCR for melatonin, is sig- nificantly under-expressed only in the Non-WNT/SHH group of medulloblastoma tumors ...of protein kinase A (PKA) and protein kinase C (PKC) with a subsequent increase in ...
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The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation
... three G protein-coupled receptors (GPCR), T cell death-associated gene 8 (TDAG8 also known as GPR65), ovarian cancer G protein-coupled receptor 1 (OGR1 also known ...
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Computational Predictions of G Protein Coupled Receptor Structures and Binding Sites
... G protein-coupled receptors (GPCRs) are the largest family of proteins within the human genome. They consist of seven transmembrane (TM) helices, with a N- terminal region of varying length and ...
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CHARACTERIZATION OF EIF2Bε AND ITS INTERACTION WITH RGS2
... G protein-coupled receptors (GPCRs) are a class of seven transmembrane domain proteins found in many types of animal cells and ...heterotrimeric G proteins by promoting GTP binding in exchange ...
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Aquatic adaptation and the evolution of smell and taste in whales
... of G-protein coupled receptors (GPCRs) encoded by dif- ferent multigene families to each other: olfactory recep- tors (ORs), trace amine-associated receptors (TAARs) and two types of vomeronasal ...
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Recent insights from molecular dynamics simulations
... simulation studies and enhanced sampling methods used to study biased G protein-coupled receptor.. 18.[r] ...
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COMPUTATIONAL ANALYSIS OF G PROTEIN COUPLED RECEPTOR SCREENING, DIMERIZATION, AND DESENSITIZATION
... a protein in the ...the G-protein number, the membrane assay can be refocused to detect drugs with a particular ...of G- proteins must be reduced to better match the whole cell binding ...
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Role of C-C chemokine receptor type 7 and its ligands during neuroinflammation
... Studies conducted using two-dimensional microfluidic devices have shown that CCL19 is apparently 100-fold more potent than CCL21 for DC chemotaxis [38], and is also a more potent chemoattractant than CXCL12 for activated ...
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Download Download PDF
... Although associations between SNPs of GPR30 and sev- eral diseases, such as breast carcinoma [20], seminoma [27], and gynecomastia [28], have been investigated, this is the first study to investigate the association ...
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G protein coupled receptor kinase activity is increased in hypertension
... arrestin protein expression was determined by immunoblotting. GRK-2 protein expression was determined using a 1:100 dilution of a mouse monoclonal antibody 3A10, raised against purified recombi- nant bovine ...
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Design, Synthesis, and Evaluation of Novel Protease-Activated Receptor 2 (PAR2)-Targeting Imaging Agents for Cancer
... of G protein-coupled receptors ...subunit G protein (α, β, and ...the receptor, causing its intracellular G protein to replace GDP with ...
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