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Growth differentiation factor 15

A meta-analysis of genome-wide association studies of growth differentiation Factor-15 concentration in blood

A meta-analysis of genome-wide association studies of growth differentiation Factor-15 concentration in blood

... Growth differentiation factor-15 (GDF-15), also known as macrophage inhibitory cytokine-1 (MIC-1), is a stress response cytokine and a divergent member of the transforming growth ...

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Growth differentiation factor 15 contributes to cancer-associated fibroblasts-mediated chemo-protection of AML cells

Growth differentiation factor 15 contributes to cancer-associated fibroblasts-mediated chemo-protection of AML cells

... migration, growth and chemo-resistance of tumor cells in several solid tumors, including human prostate, pancreatic, colo- rectal carcinoma, and in hematologic malignancies, such as multiple myeloma, and the ...

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Growth differentiation factor 15 contributes to marrow adipocyte remodeling in response to the growth of leukemic cells

Growth differentiation factor 15 contributes to marrow adipocyte remodeling in response to the growth of leukemic cells

... higher growth differentiation factor 15 (GDF15) than the other three cytokines associated with adipocyte differentiation in RNA level but also secreted GDF15 ...

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Original Article Downregulation of growth differentiation factor-15 in trichostatin A-induced apoptosis could play a role in progression of gastric cancer

Original Article Downregulation of growth differentiation factor-15 in trichostatin A-induced apoptosis could play a role in progression of gastric cancer

... on growth inhibi- tion and apoptosis of BGC-823 ...in growth differentiation factor-15 (GDF-15) was verified by qRT-PCR and Western ...

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Serum Growth Differentiation Factor 15 in Patients with Ulcerative Colitis

Serum Growth Differentiation Factor 15 in Patients with Ulcerative Colitis

... Increased cytokine levels during inflammation are said to play a major role in the pathogenesis of ACD at various levels. It affects EPO production, erythroid response to EPO, life span of red blood cells and iron ...

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Determinants of growth differentiation factor 15 in patients with stable and acute coronary artery disease. A prospective observational study

Determinants of growth differentiation factor 15 in patients with stable and acute coronary artery disease. A prospective observational study

... in patients with high risk NSTEMI [5]. In patients with STEMI a recent sub-study of the PLATO trial showed predictive impact of admission GDF-15 for future spon- taneous MI and death [32]. A further analysis of ...

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Preoperative plasma growth differentiation factor 15 for prediction of acute kidney injury in patients undergoing cardiac surgery

Preoperative plasma growth differentiation factor 15 for prediction of acute kidney injury in patients undergoing cardiac surgery

... hemofiltration during ECC, plasma GDF-15, hsTNT, and NTproBNP) role as risk factors for CSA-AKI, we observed that GDF-15 is an independent predictor of CSA-AKI and confirmed this finding using multiple ...

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Growth differentiation factor 15 deficiency protects against atherosclerosis by attenuating CCR2-mediated macrophage chemotaxis

Growth differentiation factor 15 deficiency protects against atherosclerosis by attenuating CCR2-mediated macrophage chemotaxis

... In conclusion, we are the first to demonstrate that leuko- cyte deficiency of GDF-15 improves atherosclerotic plaque stability by impairing macrophage migration and inducing collagen deposition. Our data not only ...

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Potential relation between soluble growth differentiation factor-15 and testosterone deficiency in male patients with coronary artery disease

Potential relation between soluble growth differentiation factor-15 and testosterone deficiency in male patients with coronary artery disease

... The current study suffers from some limitations. First, it was a case–control study, which meant that it could only show associations, not causality. And more lon- gitudinal studies and follow-up are required to confirm ...

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Acute exacerbations of chronic obstructive pulmonary disease are associated with decreased CD4+ & CD8+ T cells and increased growth & differentiation factor-15 (GDF-15) in peripheral blood

Acute exacerbations of chronic obstructive pulmonary disease are associated with decreased CD4+ & CD8+ T cells and increased growth & differentiation factor-15 (GDF-15) in peripheral blood

... Our results in peripheral blood complement two stud- ies showing increased percentages of total lymphocytes (defined by cytospin differential counts) in sputum in this setting [14, 15]. Collectively, these two ...

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Growth differentiation factor-15 is associated with muscle mass in chronic obstructive pulmonary disease and promotes muscle wasting in vivo

Growth differentiation factor-15 is associated with muscle mass in chronic obstructive pulmonary disease and promotes muscle wasting in vivo

... sociated with exercise capacity in both patient cohorts. COPD patients show a fi bre shift from a predominance of type I fi bres to a predominance of type IIA fi bres in the quadriceps muscle, and this change in fi bre ...

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Growth differentiation factor 15 and early prognosis after out-of-hospital cardiac arrest

Growth differentiation factor 15 and early prognosis after out-of-hospital cardiac arrest

... Several limitations of our study should be noted. First and foremost, it was performed at a single center and involved a small number of patients, which limited the generalization of our observations. Included popula- ...

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Growth differentiation factor-15 is associated with cardiovascular outcomes in patients with coronary artery disease

Growth differentiation factor-15 is associated with cardiovascular outcomes in patients with coronary artery disease

... a growth inhibitory molecule in tissue ...necrosis factor-α, and CRP induce GDF- 15 expression in macrophage cells through the regula- tion of p53 binding sites in the GDF-15 promoter ...

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Growth differentiation factor 15 and prognosis in acute respiratory distress syndrome: a retrospective cohort study

Growth differentiation factor 15 and prognosis in acute respiratory distress syndrome: a retrospective cohort study

... Of the 513 patients enrolled in the FACT Trial assigned to the PAC arm, 501 received a PA catheter. Of those that received a PAC, 400 patients were eligible for inclu- sion in this analysis (Figure 1). The most common ...

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Dynamic derangement in amino acid profile during and after a stroke like episode in adult onset mitochondrial disease: a case report

Dynamic derangement in amino acid profile during and after a stroke like episode in adult onset mitochondrial disease: a case report

... measured growth differentiation factor-15 and multiple amino acids in his blood, longitudinally during and after the stroke-like ...episode. Growth differentiation ...

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Growth and differentiation factor 15 regulates PD-L1 expression in glioblastoma

<p>Growth and differentiation factor 15 regulates PD-L1 expression in glioblastoma</p>

... In this study, we aimed to explore the role of GDFs in GBM. In our preliminary analysis, GDF15 and MSTN were identi fi ed as candidate tumor-promoting genes in GBM. GDF15 has been shown to play a crucial role in the ...

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Growth differentiation factor 9 and bone morphogenetic protein 15 expression in previtellogenic oocytes and during early embryonic development of Yellow-tail Kingfish Seriola lalandi

Growth differentiation factor 9 and bone morphogenetic protein 15 expression in previtellogenic oocytes and during early embryonic development of Yellow-tail Kingfish Seriola lalandi

... After standardization of PCR conditions, we evaluated the relative expression of gdf9 and bmp15 genes in previ- tellogenic oocytes and during different embryo develop- ment stages in S. lalandi. Three biological ...

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Genetic analysis of female infertility with the effect of human  bmp15 and gdf9 genes: a review

Genetic analysis of female infertility with the effect of human bmp15 and gdf9 genes: a review

... family: growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) originates from oocytes are played a very ollicle growth and these two genes drastically altered ...

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Integration of proteomic and transcriptomic profiles identifies a novel PDGF-MYC network in human smooth muscle cells

Integration of proteomic and transcriptomic profiles identifies a novel PDGF-MYC network in human smooth muscle cells

... GDF15: Growth and Differentiation Factor 15; GFP: Green Fluorescent Protein; GOBP: Gene Ontology biological processes; HMOX-1: Heme Oxygenase-1; HPLC: High Performance Liquid Chromatography; ...

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Epidermal growth factor enhances osteogenic differentiation of dental pulp stem cells in vitro

Epidermal growth factor enhances osteogenic differentiation of dental pulp stem cells in vitro

... various growth factors [15, ...osteogenic differentiation of DPSCs [17] through inhibition of ALP enzymatic activity and mineralization ...epidermal growth factor receptor (EGFR), a ...

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