growth differentiation factor 6
Growth differentiation factor 6 and transforming growth factor beta differentially mediate mesenchymal stem cell differentiation, composition, and micromechanical properties of nucleus pulposus constructs
... Growth differentiation factor 5 (GDF5/BMP-14/CDMP- 1) and growth differentiation factor 6 (GDF6/BMP-13/ CDMP-2) are members of the TGF superfamily and are as- sociated ...
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Functional similarities of microRNAs across different types of tissue stem cells in aging
... identified growth differentiation factor 6 (Gdf6; also known as Bmp13 and CDMP-2) as a regen- erative factor secreted by young MSCs [21, ...the differentiation potential of old ...
5
Serum Growth Differentiation Factor 15 in Patients with Ulcerative Colitis
... such as iron status of the body, hypoxia, erythroid activity and inflammation. Low iron levels, increased erythropoiesis, and hypoxia act as negative regulators, thus decreasing hepcidin, thereby increasing iron ...
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Diclofenac and triamcinolone acetonide impair tenocytic differentiation and promote adipocytic differentiation of mesenchymal stem cells
... tenocytic differentiation of the fibroblast-like C3H10T1/2 ...transforming growth factor beta superfamily, which is a group of growth factors known to induce growth and ...
6
Growth differentiation factor 15 contributes to marrow adipocyte remodeling in response to the growth of leukemic cells
... In this study, both on BM sections and in AML cell lines, our experiments showed that AML cells highly expressed GDF15. As a secretory protein, GDF15 might be released into the BM cavity by leukemic cells and have an ...
10
Growth differentiation factor 9 and bone morphogenetic protein 15 expression in previtellogenic oocytes and during early embryonic development of Yellow-tail Kingfish Seriola lalandi
... transforming growth factor β super family (TGF-β), GDF9 and BMP15 ...These growth factors stimulate the proliferation of granu- lose cells, but also suppress follicle stimulating hormone ...
7
Neuroendocrine Differentiation in the Progression of Prostate Cancer: An Update on Recent Developments
... like growth factors (insu- lin-like growth factor I (IGF-I), keratinocyte growth fac- tor (KGF)) and cytokines (interleulin 6 (IL-6)) to mimic the effect of androgens through the ...
10
Nerve growth factor: role in growth, differentiation and controlling cancer cell development
... 4, 6, ...(i) differentiation and (ii) sur- vival of developing neurons belonging to peripheral and central nervous system as well as in the (iii) protection of degenerating young and adult neurons ...
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Salivary Epidermal Growth Factor in Mice Modulates the Differentiation of CD4CELLS in Thymus
... 2) Immunofluorescences Staining Protocol: (Fig. 2): The sections were treated with Antigen retrieval solution with citrate buffer (pH 6) in pressure cooker or microwave oven (15 minutes at high flame and 30 ...
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Developmental tumours, early differentiation and the transforming growth factor beta superfamily
... Expression of the activin type I and type II receptors in mouse development has been well-studied for the period of organogen- esis (Feijen et al., 1994; Verschueren et al., 1995). However, as yet there has been no ...
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Activin signaling as an emerging target for therapeutic interventions
... Activin signals are transmitted through two types of trans- membrane serine/threonine kinase receptors, type I and type II activin receptors in target cells [1,4]. Activin recep- tors are prototypes of single-pass ...
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The Effect of Growth Differentiation Factor-5, 6, 7 in Chondrogenic Cell Differentiation of ATDC-5
... chondrogenic differentiation marker genes (Sox9, Collagen Type II (Col2), Collagen Type X (ColX), and Aggrecan) were analyzed using real-time quantitative RT-PCR (MX3005P, Agilent Technologies, Tokyo, Japan); ...
5
Building Muscle: The Role of Insulin-Like Growth Factor Binding Protein-6 and Insulin-Like Growth Factors in the Differentiation of Placental Mesenchymal Stem Cells into Skeletal Muscle
... IGF-mediated differentiation are still under investigation, IGFs can induce myogenic transcription factors ...muscle differentiation) in C3H 10T1/2 mouse embryonic fibroblast cells induced IGF-2 expression, ...
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Single Nucleotide Polymorphism Analysis of the Bone Morphogenetic Protein Receptor IB and Growth and Differentiation Factor 9 Genes in Rayini Goats (Capra hircus)
... Wilson, T., Wu, X.Y., Juengel, J.L., Ross, I.K., Lumsden, J.M., Lord, E.A., Dodds, K.G., Walling, G.A., McEvan, J.C., O’C M N y K P Montgomery, G.W., 2001.Highly prolific Booroola sheep have a mutation in the ...
6
An inversion involving the mouse Shh locus results in brachydactyly through dysregulation of Shh expression
... (5), growth and differentiation factor 5 (GDF5) (6), BMP-receptor 1B (BMPR1B) (7), and the receptor tyrosine kinase ROR2 (8, 9) have been shown to cause distinct subtypes of brachy- dactyly, a ...
11
The role of TGF superfamily gene expression in the regulation of folliculogenesis and oogenesis in mammals: a review
... a growth factor signalling cascade that highly regulates the proliferation and differentiation of ovarian cells (Figure 1), (Nagashima et ...important growth factors include genes of the TGFB ...
11
Human infrapatellar fat pad derived stem cells express the pericyte marker 3G5 and show enhanced chondrogenesis after expansion in fibroblast growth factor 2
... of differentiation potential. Fibroblast growth fac- tor-2 (FGF-2) is a potent mitogen for a variety of cell types derived from the mesoderm, including chondrocytes ...and differentiation of bone ...
11
Growth factor TGF-β induces intestinal epithelial cell (IEC-6) differentiation: miR-146b as a regulatory component in the negative feedback loop
... on differentiation of intestinal epithelial cells is closely associated with its tumor suppressing effects; therefore, it is of significance to examine whether and how miR-146b is involved in this important ...
10
Original Article Effects of insulin-like growth factor 2 and its receptor expressions on corneal repair
... This study found prominent expression of cell proliferation and differentiation related cyto- kines after corneal injury. Those cytokines may penetrate lacrimal membrane, aqueous humor and epithelial layer to ...
7
Investigation of β-Catenin-Mediated Regulation of IGFBP-6 and the Roles of IGFBP-6 and IGF-II in Dupuytren's Disease
... and differentiation of palmar fascia fibroblasts into myofibroblasts, the hyper-contractile cell type that remodels the palmar fascia to induce finger contractures in ...transforming growth factor-β1 ...
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