H7N9 influenza
Role of Poultry in the Spread of Novel H7N9 Influenza Virus in China
... of H7N9 influenza is complicated by the lack of disease signs in ...the H7N9 virus was unusual, in that virus replication was primarily restricted to the upper respiratory tract for all the species ...
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Pathogenicity of the Novel A/H7N9 Influenza Virus in Mice
... of H7N9 influenza viruses were first de- tected in China during February and March 2013 ...avian influenza A (H9N2) viruses while the H7 and N9 surface proteins originate from duck and wild-bird ...
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Diversity of the RNA Polymerase in the H7N9 Influenza A Virus
... novel influenza virus of the H7N9 subtype has infected more than 350 people in China since 19 February ...avian influenza viruses, and bears some amino acids associated with mammalian receptor ...
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Induction of Cross-Reactive Antibodies to Novel H7N9 Influenza Virus by Recombinant Newcastle Disease Virus Expressing a North American Lineage H7 Subtype Hemagglutinin
... of H7N9 influenza virus warrants ...avian influenza viruses (16, 21). Recombinant NDV vaccines for avian influenza virus are approved for use and have been widely ...
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Transmission of H7N9 influenza virus in mice by different infective routes
... novel influenza A H7N9 virus from an avian source showed symptoms of ...human-to-human H7N9 virus transmission has not been documented between individuals having close contact; however, this ...
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Characterization of Influenza Vaccine Hemagglutinin Complexes by Cryo-Electron Microscopy and Image Analyses Reveals Structural Polymorphisms
... SDS-PAGE and immunoblotting. Hemagglutinin proteins were ob- tained from Protein Sciences Corporation (Meriden, CT) and were re- combinant full-length H7 proteins of the A/Netherlands/219/2003 (H7N7) and A/Anhui/1/1013 ...
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Fc functional antibodies in humans with severe H7N9 and seasonal influenza
... severe influenza infection in different geographical regions compared with ...al influenza-infected cohort, we speculate that this reflects the presence of cross-reactive memory B cells prior to infection ...
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Influenza Virus A/Anhui/1/2013 (H7N9) Replicates Efficiently in the Upper and Lower Respiratory Tracts of Cynomolgus Macaques
... the H7N9 influenza virus strains isolated from human cases have an R292K substitution in NA that renders them partially resistant to treatment with neuraminidase inhibitors (12, 43–45), it is important to ...
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Rapid and Sensitive Detection of H7N9 Avian Influenza Virus by Use of Reverse Transcription–Loop Mediated Isothermal Amplification
... the H7N9 epi- demic, it is necessary that the characterization of influenzalike cases, especially severe pneumonia in humans, and H7N9 avian influenza virus (AIV) detection in migratory birds and ...
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Anti H7N9 avian influenza A virus activity of interferon in pseudostratified human airway epithelium cell cultures
... In 1986, rhIFN-α2b was approved by US FDA for the clinical treatment of diseases such as hair cell leukemia, AIDS-related kaposi’s sarcoma, and chronic hepatitis B and C, achieving great social and economic benefits. ...
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Attitudes, practices and information needs regarding novel influenza A (H7N9) among employees of food production and operation in Guangzhou, Southern China: a cross sectional study
... to H7N9 influenza among employees of food production and operation just three months after the first human in- fection case reported in China, and one month after chick- ens were found to be infected in ...
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Influenza H7N9 and H9N2 Viruses: Coexistence in Poultry Linked to Human H7N9 Infection and Genome Characteristics
... Avian influenza virus A of the novel H7N9 reassortant subtype was recently found to cause severe human respiratory infections in ...human H7N9 infection sources, based on the cases’ exposure his- ...
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Immune derangement occurs in patients with H7N9 avian influenza
... avian H7N9 influenza developed T-cell ...with H7N9 avian influenza may be a key factor leading to high morbid- ity and mortality, because lymphocytopenia is an inde- pendent risk factor for ...
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Transmission potential of influenza A/H7N9, February to May 2013, China
... A/H7N9 influenza virus infections rapidly unfolded in Eastern China, with the first laboratory-confirmed case identified in Shanghai on 31 March 2013 and a total of 132 laboratory-confirmed cases and 38 ...
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Transcriptomic Characterization of the Novel Avian Origin Influenza A (H7N9) Virus: Specific Host Response and Responses Intermediate between Avian (H5N1 and H7N7) and Human (H3N2) Viruses and Implications for Treatment Options
... avian-origin H7N9 influenza A virus (IAV) emerged in China in 2013, causing mild to lethal human respira- tory ...infections. H7N9 originated with multiple reassortment events between avian viruses ...
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Population seroprevalence of antibody to influenza A(H7N9) virus, Guangzhou, China
... considerable uncertainty. Because we did not collect de- tailed patient information such as exposures when obtain- ing the sera specimens, we were unable to explore risk factors for infection. Larger serological studies ...
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H7N9 and Other Pathogenic Avian Influenza Viruses Elicit a Three-Pronged Transcriptomic Signature That Is Reminiscent of 1918 Influenza Virus and Is Associated with Lethal Outcome in Mice
... scriptional responses in mice. Variation in morbidity and elicita- tion of proinflammatory cytokines and chemokines in murine lungs postinoculation among viruses which replicate to compara- ble titers has been ...
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Novel Avian-Origin Influenza A (H7N9) Virus Attachment to the Respiratory Tract of Five Animal Models
... explants, H7N9 Anhui virus titers were approximately 100 ⫻ higher than titers of H5N1 and H3N2 viruses at 48 hpi, although these differences were not statistically signifi- cant ...pieces, H7N9 Anhui virus ...
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Highly pathogenic avian influenza H7N9 viruses with reduced susceptibility to neuraminidase inhibitors showed comparable replication capacity to their sensitive counterparts
... Since 2010, neuraminidase inhibitors (NAIs) are the only class of antivirals recommended by the WHO for the treatment of influenza infections [8]. The approved NAIs in China, including oseltamivir, zanamivir and ...
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Lung ultrasound imaging in avian influenza A (H7N9) respiratory failure
... Our first patient had all of the sonographic findings (B lines, confluent B lines, small subpleural consolidations, spared areas, and pleural effusion) described for ARDS [10] that were noted to be resolving on serial ...
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