hematopoietic stem and progenitor cell
Hematopoietic stem and progenitor cell harvesting: technical advances and clinical utility
... Abstract: Hematopoietic stem and progenitor cell (HSPC) transplantations require prior harvesting of allogeneic or autologous HSPCs. HSPCs are usually present in bone marrow (BM) during the ...
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Bone marrow dendritic cells regulate hematopoietic stem/progenitor cell trafficking
... the stem cell niche is largely ...in hematopoietic stem/progenitor cell (HSPC) mobilization that was greater than that seen with ablation of bone marrow macrophages, and cDC ...
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Purinergic P2Y14 receptor modulates stress induced hematopoietic stem/progenitor cell senescence
... immune cell phagocytosis. Here, we have demonstrated that P2Y 14 modifies cell senescence and cell death in response to tissue stress, thereby enabling preservation of hematopoietic ...
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Novel methods for determining hematopoietic stem and progenitor cell emergence in the murine yolk sac
... of hematopoietic progenitors, is the focus of another set of experiments that are helping define cellular interactions of hematopoietic progenitors with their envi- ronment (Emambokus and Frampton, ...of ...
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Adenosine signaling promotes hematopoietic stem and progenitor cell emergence
... flow, cell proliferation and differentia- tion, and stem cell regeneration (Glaser et ...through cell surface re- ceptors (Rossi et ...
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CCR2 mediates hematopoietic stem and progenitor cell trafficking to sites of inflammation in mice
... or progenitor-enriched BM cells (5–7, ...retain hematopoietic markers have been found in the heart and likely mediate improved myocyte function through paracrine effects ...G-CSF–primed hematopoietic ...
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Mobilization of hematopoietic stem cells from the bone marrow niche to the blood compartment
... A role for osteoclasts in mobilization was shown by treating mice with RANK ligand, which increased osteo- clast activity that correlated with a moderate increase in hematopoietic progenitor cell ...
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Stem cell biology is population biology: differentiation of hematopoietic multipotent progenitors to common lymphoid and myeloid progenitors
... The hematopoietic stem cell (HSC) system is a demand control system, with the demand coming from the organism, since the products of the common myeloid and lymphoid progenitor (CMP, CLP ...
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Enhanced self-renewal of hematopoietic stem/progenitor cells mediated by the stem cell gene Sall4
... We next extended our study to a myeloid progenitor cell line (32D), to determine how Sall4 may affect hematopoie- tic progenitor cell differentiation. 32D cells were cultured and infected with ...
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Characterization of Hemangioma-initiating Stem Cells
... for hematopoietic and progenitor cell markers using primary antibodies for one hour at room temperature, with the exception of CD45 (Table ...
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Role of Spy1 in hematopoiesis: Implications for blood malignancies
... of hematopoietic progenitors capable of forming hematopoietic colonies in vitro has been observed in many murine adult organs including the liver and the spleen 90-91 ...in hematopoietic tissues is ...
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The role and potential of umbilical cord blood in an era of new therapies: a review
... In light of pioneering findings in the 1980s and an estimation of more than 130 million global annual births, umbilical cord blood (UCB) is considered to be the most plentiful reservoir of cells and to have regenerative ...
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Cusan, Monica (2012): Studie über das leukämogene Potential der Hoxb4-DeltaProlin Mutante in einem murinen Knochenmarkstransplantationsmodell und den Effekt der Hemmung von Histondeacetylasen in vitro und in vivo. Dissertation, LMU München: Medizinische Fakultät
... the hematopoietic development of human embryonic stem cells in vitro (Bowles ...BM progenitor cells induces a 50fold increase in the number of transplantable HSCs, compared to control cells ...
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Hematopoietic stem cells and retroviral infection
... Leukemia Stem Cells/Cancer Stem Cells (LSC/CSC) The cancer stem cell hypothesis postulates that cancer can be initiated, sustained and maintained by a small number of malignant cells that have ...
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Vol 70, No 3 (2018)
... – hematopoietic stem cells; HSPC − hematopoietic stem/progenitor cells; HOXB4 – homeobox protein Hox-B4; TNC –total nucleated cells; CFU – colony forming unit; MSC – mesenchymal ...
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Engineering approaches for regeneration of T lymphopoiesis
... T cell development ...T cell tolerance and MHC restriction in ...T cell progenitors and further development of the grafted tissue to an ectopic, functional ...human hematopoietic stem ...
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Sex Steroids and Stem Cell Function
... of hematopoietic stem cells utilizes “selec- tive amplifier genes” that encode fusion proteins (granulocyte colony-stimulating factor [G-CSF] mutant receptor and delta G-CSF mutant receptor) between the ...
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Arterial endothelium creates a permissive niche for expansion of human cord blood hematopoietic stem and progenitor cells
... mesenchyme, hematopoietic cells are in close vicinity of endothelial cells ...and hematopoietic cells de- velop in parallel ...endothelial cell development and arterial specification in the embryo ...
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Novel regenerative therapy for acute kidney injury
... strategies: cell transplantation and kidney reconstruction. Regarding cell transplantation, several cell types are potential sources, including hematopoietic stem cells, mesenchymal ...
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Multipotent (adult) and pluripotent stem cells for heart regeneration: what are the pros and cons?
... mixed cell population, such as nodal, atrial and ventricular phenotypes [52], as well as immature electro- physiological properties, including lengthened action dur- ation and depolarized resting membrane ...
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