Hemostasis and Thrombosis
Microfluidic Approaches to Thrombosis and Hemostasis: Towards a Patient-Specific Test of Antiplatelet Therapeutics and the Assessment of Coagulopathy in Hemophilic and Trauma Patients
... of hemostasis and thrombosis fail to recapitulate the hemodynamic conditions and biorheologic phenomena found throughout the ...in hemostasis and thrombosis is essential in advancing our ...
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Exploiting the kinetic interplay between GPIb VWF binding interfaces to regulate hemostasis and thrombosis
... located in or directly adjacent to the larger contact surface, may disrupt electrostatic interactions between this receptor–ligand pair or induce structural changes that reduce GPIb α binding. In contrast, type 2B ...
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Plasma fibronectin supports hemostasis and regulates thrombosis
... rendering them unlikely to be easily accessed by integrins from 2 platelets. When the N terminus of pFn cross-links with fibrin, the large pFn-fibrin complex may then be able to bind to platelets at RGD motifs on pFn ...
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Plasminogen activator inhibitor 1 gene deficient mice II Effects on hemostasis, thrombosis, and thrombolysis
... on hemostasis, thrombosis and thrombolysis were studied in homozygous PAI-1-deficient (PAI-1-/-) mice, generated by homologous recombination in D3 embryonic stem ...
6
Emerging technologies in hemostasis diagnostics: A report from the Australasian Society of Thrombosis and Haemostasis Emerging Technologies Group
... in hemostasis laboratories has evolved enormously during the last 30 ...the hemostasis laboratory today uses a variety of modern ...in hemostasis and discusses whether they have improved or are ...
9
Global assays of hemostasis in the diagnostics of hypercoagulation and evaluation of thrombosis risk
... use, thrombosis is still responsible for a lion ’ s share of mortality and morbidity in the modern ...of hemostasis process in ...of thrombosis) can be used for clinical decisions: the risk ...
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Dynamics of Thrombosis and Hemostasis System Indicators in Rats With Thrombosis of Inferior Vena Cava in Experiment as A Model for Preclinical Studies.
... cava thrombosis model in rats with the definition of the main markers that can be used to study the efficacy of antithrombotic agents means at the stage of preclinical ...and hemostasis system in rats ...
9
Genetic background determines response to hemostasis and thrombosis
... arterial thrombosis formation in a FeCl 3 vascular injury model, rebleeding time in a tail bleeding assay, plasminogen function, and tissue and vessel collagen ...
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Effects of monoclonal antibodies against the platelet glycoprotein IIb/IIIa complex on thrombosis and hemostasis in the baboon
... We have therefore used a baboon animal model to assess the effects of injected antibodies against platelet GP Ilb/IIIa with respect to the following variables: platelet count, bleeding t[r] ...
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A Microfluidic Approach for Investigating the Role of Intrathrombus Transport in Thrombosis and Hemostasis
... Throughout Chapters 2-4 we have described a microfluidic device capable of studying clot growth and architecture at controlled wall shear rates and transthrombus pressure gradients. While this device excels in models of ...
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Low levels of tissue factor are compatible with development and hemostasis in mice
... Regulation of the human TF (hTF) gene has been charac- terized extensively in vitro (for a recent review see reference 27). LPS and cytokine induction in both monocytic cells and endothelial cells is mediated by a distal ...
11
Rap1b is required for normal platelet function and hemostasis in mice
... We would like to thank our colleagues from the University of North Carolina at Chapel Hill: Randy Thresher (Animal Models Core Facility) for his help with the targeting vector, Jennifer Cullen, Anna Kraus and Eleanor ...
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Platelet secretion and hemostasis require syntaxin binding protein STXBP5
... Cardiovascular diseases, such as myocardial infarction, stroke, and deep vein thrombosis, are leading causes of death and dis- ability. These potentially occlusive processes are influenced in part by platelet ...
13
Assessment of the relationship between thyroid diseases involvement and effect on hemostasis; a prospective analysis of hemostasis profiles in women with control group in Saudi Arabia
... There has been strong relationship between abnormal hemostatis and thyroid diseases for long time and have been known since the beginning of the past century (8). With the first clinical link has been described in 1913, ...
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Microfluidic Focal Injury Models of Thrombosis and Hemostasis
... factor with known activity on the surface, by controlling bead density, antibody cov- erage, and tissue factor:lipid ratio during relipidation. This control is of the utmost importance when working with a system with ...
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Level of overall hemostasis potential in donor and patient plasma in pathology
... global hemostasis assay developed by ...other hemostasis markers in patients' blood ...vein thrombosis associated with resistance to activated protein C, an increased procoagulant ac ...
10
Point-of-Care Testing of Hemostasis in Cardiac Surgery
... 4. The Platelet function Analyzer-100 (PFA-100, DADE Behring, USA) assesses whole blood platelet function by measuring the closure time (CT) [58] required for plate- lets in citrated whole blood to occlude a precisely ...
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Hemostasis Imbalance in Experimental Hypertension
... Hypertension is an important risk factor for cardio- vascular morbidity and mortality (1). Myocardial in- farction, nephroangiosclerosis, and stroke, which are complications of hypertension, predominantly occur due to ...
10
Specifics of Platelet Hemostasis in Children with Chronic Diseases of Lungs
... Study of platelet aggregation function can help early diagnostics of microvasculature’s disorders. Purpose of the study is evaluation of changes of platenet aggregation activity in children with chronic inflammation. ...
6
Platelet-targeted dual pathway antithrombotic inhibits thrombosis with preserved hemostasis
... SCE5-TAP demonstrates antiplatelet and anticoagulant activity. The objective of this study was to develop a dual pathway therapeutic capable of concentrating antiplatelet and anticoagulant activity at the site of clot ...
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