Herpes Simplex Virus (HSV)
The Membrane Proximal Region (MPR) of Herpes Simplex Virus gB Regulates Association of the Fusion Loops with Lipid Membranes
... [herpes simplex virus] receptor HVEM) with effector CHO cells (expressing T7 polymerase, gD, gH, and gL, plus either WT gB, mutant gB, or empty vector ...
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Quantitation of herpes simplex virus type 1 DNA and latency-associated transcripts in rabbit trigeminal ganglia demonstrates a stable reservoir of viral nucleic acids during latency.
... Herpes simplex virus type 1 (HSV-1), an alphaherpesvirus, is neurotropic and establishes lifelong latency in the nervous ...of virus into axon terminals and viral transport to neuron cell ...
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The Fusion Loops of the Initial Prefusion Conformation of Herpes Simplex Virus 1 Fusion Protein Point Toward the Membrane
... understood. Herpes simplex virus (HSV), a model sys- tem for herpesviruses, causes diseases ranging from mild skin lesions to serious encephalitis and neonatal ...
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Structure-function analysis of soluble forms of herpes simplex virus glycoprotein D.
... Herpes simplex virus (HSV) encodes at least 11 glycopro- teins (50). The initial attachment of HSV with cell surface heparan sulfate is mediated by glycoprotein C (gC) and/or gB (12, 22, 23, 61). ...
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The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways
... Human herpes simplex virus (HSV) is a ubiquitous human pathogen that establishes a lifelong latent infection and is associated with mucocutaneous ...
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Effect of Apolipoprotein E on the Cerebral Load of Latent Herpes Simplex Virus Type 1 DNA
... Herpes simplex virus type 1 (HSV-1) is neurotropic and enters a latent state lasting the lifetime of the ...the virus in the nervous system than the wild-type mice, while the APOE4 mice had ...
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A Gene Capable of Blocking Apoptosis Can Substitute for the Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene and Restore Wild-Type Reactivation Levels
... ocular herpes simplex virus type 1 (HSV-1) infection, the virus travels up axons and establishes a lifelong latent infection in neurons of the trigeminal ...HSV-1 virus in which the ...
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Incorporation of the Green Fluorescent Protein into the Herpes Simplex Virus Type 1 Capsid
... The herpes simplex virus type 1 (HSV-1) UL35 open reading frame (ORF) encodes a 12-kDa capsid protein designated ...A virus, designated K26GFP, was isolated and purified and was shown to grow ...
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Heptad Repeat 2 in Herpes Simplex Virus 1 gH Interacts with Heptad Repeat 1 and Is Critical for Virus Entry and Fusion
... Herpes simplex virus 1 (HSV-1) entry into cells and cell-cell fusion mediated by HSV-1 glycoproteins require four glycoproteins, gD, gB, gH, ...
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Attenuated, Replication-Competent Herpes Simplex Virus Type 1 Mutant G207: Safety Evaluation in Mice
... Herpes simplex virus type 1 (HSV-1) is a neurotropic DNA virus which infects a wide range of cell types in different ani- ...replicating virus, the lack of viral gene expres- sion ...
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Functional Analysis of the Triplex Proteins (VP19C and VP23) of Herpes Simplex Virus Type 1
... In herpes simplex virus type 1 (HSV-1), one molecule of VP19C and two of VP23 form a three-pronged structure that acts to stabilize the capsid shell through interactions with adjacent VP5 ...for ...
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Cellular Proteasome Activity Facilitates Herpes Simplex Virus Entry at a Postpenetration Step
... Herpes simplex virus (HSV) entry into cells is a multistep process that engages the host cell machinery. The proteasome is a large, ATP-dependent, multisubunit protease that plays a critical role in ...
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Herpes Simplex Virus gD and Virions Accumulate in Endosomes by Mannose 6-Phosphate-Dependent and -Independent Mechanisms
... Herpes simplex virus (HSV) glycoprotein D (gD) is modified with mannose 6-phosphate (M6P) and binds to M6P receptors ...the virus egress pathway or by endocytosis from the cell ...
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Novel Class of Thiourea Compounds That Inhibit Herpes Simplex Virus Type 1 DNA Cleavage and Encapsidation: Resistance Maps to the UL6 Gene
... of herpes simplex virus type 1 (HSV-1), a new class of thiourea inhibitors was ...varicella-zoster virus were inhibited to a lesser ...
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The First Immunoglobulin-Like Domain of HveC Is Sufficient To Bind Herpes Simplex Virus gD with Full Affinity, While the Third Domain Is Involved in Oligomerization of HveC
... The human herpesvirus entry mediator C (HveC/PRR1) is a member of the immunoglobulin family used as a cellular receptor by the alphaherpesviruses herpes simplex virus (HSV), pseudorabies ...
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Interaction of herpes simplex virus glycoprotein gC with mammalian cell surface molecules.
... of herpes simplex virus (HSV) into mammalian cells is a multistep process beginning with an attachment step involving glycoproteins gC and ...parental virus, which contains full-length ...
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Inhibition of Curcumin Treated Herpes Simplex Virus 1 and 2 in Vero Cells
... The purpose of this study was to investigate the effect of curcumin-treated Herpes simplex virus-1 (HSV-1) and Herpes simplex virus-2 (HSV-2) virions in cultured Vero cells. ...
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Syncytium-inducing mutations localize to two discrete regions within the cytoplasmic domain of herpes simplex virus type 1 glycoprotein B.
... Nucleotide sequence of a region of the herpes simplex virus type 1 gB glycoprotein gene: mutations affecting rate of virus entry and cell fusion.. The active inhibition of herpes simplex[r] ...
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Characterization of herpes simplex virus type 2 transcription during latent infection of mouse trigeminal ganglia.
... RNA from an immediate early region of the type 1 herpes simplex virus genome is present in the trigeminal ganglia of latently infected mice.. Latent herpes simplex virus type 1 transcrip[r] ...
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Cell-Dependent Differences in the Production of Infectious Herpes Simplex Virus at a Supraoptimal Temperature
... Cell-Dependent Differences in the Production of Infectious Herpes Simplex Virus at a Supraoptimal Temperature Received for publication 4 October 1971 The replication of herpes simplex vi[r] ...
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