herpes virus entry mediator
Entry Mechanisms of Herpes Simplex Virus 1 into Murine Epidermis: Involvement of Nectin-1 and Herpesvirus Entry Mediator as Cellular Receptors
... primary entry site for herpes simplex virus 1 (HSV-1) in ...and herpes- virus entry mediator (HVEM) act as efficient receptors for both serotypes of HSV and are sufficient ...
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Journal of Applied Pharmaceutical Science
... worldwide. Herpes simplex virus type 1 (HSV-1) and HSV-2 are the most common causes of genital ulceration in developed ...viral entry process: gB, gC, gD, gH, and gL (Spear, ...viral entry; ...
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Herpes Simplex Virus Entry Mediator Associates in Infected Cells in a Complex with Viral Proteins gD and at Least gH
... examined herpes simplex virus (HSV)-infected human HEp-2 cells or porcine cells that express herpes virus entry mediator (HVEM) for virus and receptor protein ...
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1-s2.0-S2372770519300324-main.pdf
... Co-stimulatory molecules can be classified into two major families: the CD28 family, including CD28 and inducible T cell co-stimulator (ICOS), and the tumor necrosis factor (TNF) receptor superfamily (TNFRSF), including ...
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Multiple roles for tumor necrosis factor α and lymphotoxin α/β in immunity and autoimmunity
... Glossary of terms BLC = B lymphocyte chemoattractant; CMV = cytomegalovirus; FDC = follicular dendritic cell; HVEM = herpes virus entry mediator; IRS-1 = insulin receptor substrate-1; LT[r] ...
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Interactions between Herpesvirus Entry Mediator (TNFRSF14) and Latency-Associated Transcript during Herpes Simplex Virus 1 Latency
... HSV-1 entry receptors in latency and reactivation and the role that LAT may play in this ...known entry routes for HSV-1 (19–23), HVEM mRNA levels significantly increased in a LAT- dependent fashion in ...
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Functional Region IV of Glycoprotein D from Herpes Simplex Virus Modulates Glycoprotein Binding to the Herpesvirus Entry Mediator
... of herpes simplex virus (HSV) is essential for virus entry and has four functional regions (I to IV) important for this ...block virus entry and to bind to the herpesvirus ...
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Herpesvirus Entry Mediator on Radiation Resistant Cell Lineages Promotes Ocular Herpes Simplex Virus 1 Pathogenesis in an Entry Independent Manner
... be produced by cells of the cornea, including cells of the epithelium, stroma, or endothelium (54, 56, 58, 81–85). The HVEM receptor, after binding any of its ligands, activates NF-B signaling (71, 86). Given that the ...
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Examination of the Kinetics of Herpes Simplex Virus Glycoprotein D Binding to the Herpesvirus Entry Mediator, Using Surface Plasmon Resonance
... the molecule; the pairings consist of Cys 1 to 5, Cys 2 to 6, and Cys 3 to 4 (Fig. 1) (23). We previously found that double cys- teine mutations in gD that removed any one disulfide bond resulted in proteins that were ...
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Herpes Simplex Virus Glycoprotein D Can Bind to Poliovirus Receptor-Related Protein 1 or Herpesvirus Entry Mediator, Two Structurally Unrelated Mediators of Virus Entry
... Comparison of variant gDs binding to HveC and HveA. (i) ANG and rid1 mutants. HSV-1 entry into CHO cells was en- hanced by expression of HveC regardless of the HSV strain tested (18). In contrast, HveA expression ...
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Structure-Based Analysis of the Herpes Simplex Virus Glycoprotein D Binding Site Present on Herpesvirus Entry Mediator HveA (HVEM)
... Structure-based mutagenesis of human growth hormone has shown that a subset of contact residues account for complex formation with the human growth hormone receptor (11, 15). The conclusion that the human growth hormone ...
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Characterization of Sex Differences in Ocular Herpes Simplex Virus 1 Infection and Herpes Stromal Keratitis Pathogenesis of Wild-Type and Herpesvirus Entry Mediator Knockout Mice
... https://doi.org/10.1002/bies.201200099). Herpes simplex virus 1 (HSV-1) causes chronic inflammatory disease in the cornea, an immune-privileged tissue, resulting in irreversible damage and blindness in ...
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Localization of a Binding Site for Herpes Simplex Virus Glycoprotein D on Herpesvirus Entry Mediator C by Using Antireceptor Monoclonal Antibodies
... block virus entry. The difficulty in blocking HSV entry into these cells might be due to the high level of HveC expressed by these cells or to the presence of other ...
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Herpes Simplex Virus Glycoprotein D Interferes with Binding of Herpesvirus Entry Mediator to Its Ligands through Downregulation and Direct Competition
... Downregulation of endogenous HVEM was assessed using primary human resting T cells in coculture experiments. After overnight cocultures, the level of surface HVEM was reduced FIG. 1. Downregulation of HVEM from the cell ...
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Heptad Repeat 2 in Herpes Simplex Virus 1 gH Interacts with Heptad Repeat 1 and Is Critical for Virus Entry and Fusion
... gD serves two functions. It acts as the receptor binding glycoprotein able to interact with two alternative protein re- ceptors, herpesvirus entry mediator and nectin 1 (10, 17, 28, 35, 52). It also ...
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Herpesvirus Entry Mediator and Nectin-1 Mediate Herpes Simplex Virus 1 Infection of the Murine Cornea
... simplex virus 1 (HSV-1), an alphaherpesvirus, is the leading cause of infectious blindness in developed countries ...the virus infects adjacent neurons and travels via retrograde transport to sensory ...
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A Role for Herpesvirus Entry Mediator as the Receptor for Herpes Simplex Virus 1 Entry into Primary Human Trabecular Meshwork Cells
... to herpes simplex virus 1 (HSV-1) infection during corneal endotheliitis and uveitis leads to elevated intraocular pressure, which is a major risk factor for glaucoma, a major blinding disease (1, 19, 21, ...
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The First Immunoglobulin-Like Domain of HveC Is Sufficient To Bind Herpes Simplex Virus gD with Full Affinity, While the Third Domain Is Involved in Oligomerization of HveC
... herpesvirus entry mediator C (HveC/PRR1) is a member of the immunoglobulin family used as a cellular receptor by the alphaherpesviruses herpes simplex virus (HSV), pseudorabies virus, ...
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Role of Nectin-1 and Herpesvirus Entry Mediator as Cellular Receptors for Herpes Simplex Virus 1 on Primary Murine Dermal Fibroblasts
... measure virus production, wt and nectin-1-deficient fibroblasts were infected at ...the virus titer was determined at various times postinfection in three independent ...
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HveA (Herpesvirus Entry Mediator A), a Coreceptor for Herpes Simplex Virus Entry, also Participates in Virus-Induced Cell Fusion
... bind virus but restrict entry (36, 43, ...try mediator A) can confer susceptibility to HSV-1 infection on normally resistant CHO cells ...mediates entry of HSV-1 into a subset of human cell ...
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