HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN D
Nuclear heterogeneous nuclear ribonucleoprotein D is associated with poor prognosis and interactome analysis reveals its novel binding partners in oral cancer
... (AUF1)/heterogeneous nuclear ribonucleoprotein D (hnRNPD) is an ARE-binding pro- tein which regulates the mRNA stability of many genes involved in cell cycle, proliferation, survival, ...
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Novel Role of Heterogeneous Nuclear Ribonucleoprotein E1 in Regulation of Apoptosis and Autophagy by a Triazole Derivative in Vascular Endothelial Cells
... Figure 2. hnRNP E1 mediated the inhibition of apoptosis and promotion of autophagy induced by JL014. (A) HUVECs were treated with 5 μM or 10 μM JL014 in basal M199 medium with serum and FGF-2 deprivation for 3h, 6h and ...
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Heterogeneous Nuclear Ribonucleoprotein K Supports Vesicular Stomatitis Virus Replication by Regulating Cell Survival and Cellular Gene Expression
... FIG 2 hnRNP K is required for VSV propagation. (A and B) VSV mRNA and antigenomic RNA levels in cells depleted of hnRNP K and infected with the virus at a low (0.01) or high (1.0) MOI (panels A and B, respectively) were ...
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A Heterogeneous Nuclear Ribonucleoprotein A/B-Related Protein Binds to Single-Stranded DNA near the 5′ End or within the Genome of Feline Parvovirus and Can Modify Virus Replication
... Recombinant DBP40 binds specifically to the 5 ⴕ end of the virus genome. The full capsid of FPV is very stable, and the viral DNA is packaged within the capsid with about 24 nt of the 5⬘ end of the genome outside of the ...
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Polypyrimidine tract-binding protein and heterogeneous nuclear ribonucleoprotein A1 bind to human T-cell leukemia virus type 2 RNA regulatory elements.
... HeLa nuclear proteins UV cross-linked to CRS RNAs with murine monoclonal antibodies, we now show that p40CRS is heterogeneous nuclear ribonucleoprotein (hnRNP) A1 and p60CRS is polypyrimidine ...
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Translational upregulation of folate receptors is mediated by homocysteine via RNA heterogeneous nuclear ribonucleoprotein E1 interactions
... When we used RNA cis-element probes with very high specific activity in experiments similar to that shown in Figure 4, the lowest concentrations of homocysteine that could stimulate interaction of the cis-element and ...
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Heterogeneous Nuclear Ribonucleoprotein A2 Participates in the Replication of Japanese Encephalitis Virus through an Interaction with Viral Proteins and RNA
... ization, was introduced into JEV-SGR-Huh7 cells. As shown in Fig. 4B, hnRNP A2 was also detected in the ER of the replicon cells transfected with FLAG-CoreM. We further ex- amined the interaction of hnRNP A2 with the ...
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A Novel Heterogeneous Nuclear Ribonucleoprotein-Like Protein Interacts with NS1 of the Minute Virus of Mice
... FIG. 7. Expression of NSAP1 in LA9 cells. Western blot analysis was per- formed on nickel column-purified His6X-partial NSAP1 (aa 334 to 562) (lanes 1) and LA9 cell lysate after separation by SDS–12% polyacrylamide gel ...
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Mutational analysis of a heterogeneous nuclear ribonucleoprotein A2 response element for RNA trafficking
... cleotide treatment on MBP RNA transport. A–C, antisense-treated cells. A, RNA staining is primarily restricted to the perinuclear cytoplasm with only one or two spots of staining away from the cell body (arrowhead). ...
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Heterogeneous nuclear ribonucleoprotein complexes from Xenopus laevis oocytes and somatic cells
... the nuclear location and demonstrated RNA-binding activity of several of their constituents, their association with at least two other hnRNP proteins (the 1A5 antigen and hnRNP L), and their sensitivity to RNase ...
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Heterogeneous Nuclear Ribonucleoprotein M Facilitates Enterovirus Infection
... hnRNP M is not required for poliovirus genomic RNA stabil- ity. The decrease in viral RNA in poliovirus-infected cells that are depleted of hnRNP M may be due to an effect on viral replication or viral RNA stability. To ...
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Role of human heterogeneous nuclear ribonucleoprotein C1/C2 in dengue virus replication
... To determine whether knockdown of hnRNP C1/C2 proteins affects cell viability and proliferation, mock- infected and DENV-infected cells that had been trans- fected with hnRNP C1/C2-specific siRNA or irrelevant control ...
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Regulation of Notch Signaling by the Heterogeneous Nuclear Ribonucleoprotein Hrp48 and Deltex in Drosophila melanogaster
... the effect of ectopic coexpression of these two proteins. We used C96-GAL4, which drives the target gene expression at the dorso- ventral (D/V) boundary of the third instar larval wing discs. Overexpression of ...
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Autoimmune response to U1 small nuclear ribonucleoprotein (U1 snRNP) associated with cytomegalovirus infection
... small nuclear RNAs (U snRNAs) and their associated proteins are highly conserved and are essential for the splicing of precursor messenger ...and D proteins as well as with the E–F–G complex (the common ...
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Serum- and Glucocorticoid-Regulated Kinase 1 Is Required for Nuclear Export of the Ribonucleoprotein of Influenza A Virus
... vRNP nuclear export in MDCK cells ...cellular nuclear export machinery, suggesting that SGK1 is involved in a distinct pathway that regulates influenza vRNP ex- ...
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Influenza Virus-Induced Caspase-Dependent Enlargement of Nuclear Pores Promotes Nuclear Export of Viral Ribonucleoprotein Complexes
... the nuclear membrane to (i) import primary RNPs into the nucleus and (ii) export newly produced RNPs across the nuclear membrane to the cell membrane, where viral assembly takes place (2, ...the ...
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Influenza C and D Viruses Package Eight Organized Ribonucleoprotein Complexes
... and D viruses have seven-segmented ...a ribonucleoprotein complex (RNP) in association with nucleoproteins and an RNA-dependent RNA polymerase in ...Influenza D virus was recently isolated from swine ...
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Method for Arrangement of Heterogeneous D Matrix
... a D-matrix explanatory model, principled philosophy is proposed by dismembering the unstructured repair verbatim data associated with the different structures in parallel through the headway of ontology based ...
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The U2 small nuclear ribonucleoprotein particle as an autoantigen Analysis with sera from patients with overlap syndromes
... The band of 50,000 D seen in antibodies I anti-U contains which control strates using a serum from a patient the U I substrate lane with sera 1, 3, 4, and 6-8 is the heavy chain of RNP p[r] ...
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Evolutionary Conservation of Eukaryotic and Archaeal Box C/D Ribonucleoprotein Complex Structure
... To characterize the role of p50 and p55 in snoRNA biogenesis and/or function, gene disruption experiments were performed in yeast (76). Loss of p50 resulted in a decrease in the accumulation of mature box C/D ...
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