Hh signaling
Fine tuning of Hh signaling by the RNA binding protein Quaking to control muscle development
... Nabel-Rosen et al., 2002; Schachner and Bartsch, 2000) via a QRE (Galarneau and Richard, 2005). A Quaking-binding site has been defined by two motifs, UACUMAY and UAAY, separated by 1-20 nucleotides. This structure has ...
12
Ihog and Boi elicit Hh signaling via Ptc but do not aid Ptc in sequestering the Hh ligand
... to Hh signaling and marks the anterior-posterior ...threshold Hh target Ptc is expressed normally within this control clone, and there is no ectopic Ptc expression in cells just anterior to the ...
10
Download Download PDF
... (Hh) signaling pathway was first identified in the common fruit ...The Hh signaling pathway plays an important role in the embryonic ...a signaling cascade that culminates in a change ...
13
Hedgehog and retinoic acid signaling cooperate to promote motoneurogenesis in zebrafish
... the Hh signaling transducer Smoothened ( MZsmo mutants) and therefore are completely devoid of ligand-dependent pathway ...of Hh signaling, and we find that their induction requires both basal ...
7
Targeting hedgehog signaling in cancer: research and clinical developments
... (Hh) signaling in mammalian ...the Hh pathway. in the absence of the Hh ligands, Hh receptor patched (PTC) is thought to be localized in the cilium to inhibit SMO ...of Hh ...
11
Spatial and temporal regulation of ventral spinal cord precursor specification by Hedgehog signaling
... that Hh signaling is required early to initiate the dorsoventral patterning process that forms the olig2 + precursor domain and late to drive olig2 precursors into an oligodendrocyte ...that Hh ...
11
Roles for Hedgehog signaling in adult organ homeostasis and repair
... Fig. 3. Roles of nerve-derived HH signaling in adult organs. (A) (Left) Schematic of the adult rodent forebrain where Shh- expressing neuronal populations (orange) in the medial septal nucleus (MSN) are ...
13
Genomic characterization of Gli activator targets in sonic hedgehog mediated neural patterning
... negative Hh- responsive expression ...general Hh pathway components, including Ptch1, Gli1, Hhip1 and Gli3, and previously reported direct neural (FoxA2) (Sasaki et ...
13
Enthesis fibrocartilage cells originate from a population of Hedgehog responsive cells modulated by the loading environment
... Hh signaling also plays an important role during the earliest stages of postnatal enthesis ...the Hh- responsive cell population is crucial for normal ...of Hh signaling in cells from ...
11
Review Article Molecular pathology and potential therapeutic targets in esophageal basaloid squamous cell carcinoma
... and HH signaling pathways cross-talk or intersect with the Notch and bone morphogenic protein pathways [43, ...Wnt signaling pathway can also control Gli3 in the HH pathway [45], and HH ...
7
The role of hedgehog signaling in gastric cancer: molecular mechanisms, clinical potential, and perspective
... (Hh) signaling pathway plays a crucial role in the development of the gastrointestinal tract and maintenance of the physiologic function of the ...activated Hh signaling is implicated in ...
10
Hedgehog participates in the establishment of left right asymmetry during amphioxus development by controlling Cerberus expression
... embryos, Hh and Ptch1 are expressed bilaterally; nevertheless, Shh −/− or Shh-Ihh compound mutants or Smo mutants exhibit an absence of Nodal expression in the LPM and of heart looping (Tsukui et ...require ...
10
Extramacrochaetae imposes order on the Drosophila eye by refining the activity of the Hedgehog signaling gradient
... As the developmental and adult retinal phenotypes of atonal (ato) mutants are nearly identical to those observed when emc and h are overexpressed (Fig. 6Q,R) (Jarman et al., 1994; Jarman et al., 1995), we examined the ...
11
Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor
... of Hh on stem cells, we examined how inhibition of Hh signaling affects LRCs in the ...of Hh signaling for up to 28 days did not result in elimination of LRCs in the epithelium ...
9
C2cd3 is required for cilia formation and Hedgehog signaling in mouse
... Hh signaling plays key roles in the regulation of ventral spinal cord patterning, digit formation and patterning of the left-right axis (Hooper and Scott, 2005), all of which are disrupted in Hty mutant ...
10
The Drosophila WIF1 homolog Shifted maintains glypican independent Hedgehog signaling and interacts with the Hedgehog co receptors Ihog and Boi
... strong Hh signaling defects caused by Ihog/Boi depletion, and lack of obvious gain-of-function phenotypes with Shf, made it difficult to address functional relevance of Ihog/Shf interactions in Hh ...
10
Dose dependent transduction of Hedgehog relies on phosphorylation based feedback between the G protein coupled receptor Smoothened and the kinase Fused
... of HH, owing to its intermolecular electrostatic interaction with acidic aa of the most C-terminal region of SMO (Zhao et ...SMO signaling activity and its accumulation at the cell surface, and they further ...
10
Role of canonical Hedgehog signaling pathway in liver
... for Hh signaling pathway activation, such as, pitchfork (Pifo), the G protein-coupled receptor associated sorting protein 2 (Gprasp2) and Growth Arrest Specific 8 (Gas8) are essential components of an ...
9
Original Article Crosstalk between Hh and Wnt signaling promotes osteosarcoma progression
... Our results demonstrate that, compared to hFOB, the expression of GLI-2 which is a tran- scriptional effector of HH signaling pathway was upregulated in both U2OS and SaOS cells. Knockdown of GLI-2 by siRNA ...
6
The cell surface proteins Dally like and Ihog differentially regulate Hedgehog signaling strength and range during development
... reduced Hh levels, suggesting that one major activity of Ihog is to retain Hh on the cell ...reduces Hh levels and signaling. This reduction of Hh signaling activity is likely to ...
12