Histone H2A.Z variants: The structure and function
Bönisch, Clemens (2012): Structure/function analyses of mammalian histone H2A and H3 variants. Dissertation, LMU München: Fakultät für Biologie
... of histone H2A variants on nucleosome as well as chromatin structure and ...on H2A variants and their biological function; the discussion focuses on their influence on ...
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Structure-Function Analysis of the Conserved Histone Chaperone Spt6
... chromatin structure, is conserved throughout ...to function in many aspects of gene expression, including nucleosome assembly, transcription initiation and elongation, and mRNA processing and ...a ...
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Kinetic and Sequence-Structure-Function Analysis of LinB Enzyme Variants with b- and d- Hexachlorocyclohexane
... 1 CSIRO Ecosystem Sciences, Acton, ACT, Australia, 2 CSIRO Center for Materials Science and Engineering, Parkville VIC, Australia, 3 Division of Engineering and Physics, Wilkes University, Wilkes-Barre, Pennsylvania, ...
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Large scale genome wide analysis identifies genetic variants associated with cardiac structure and function
... Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function Philipp S. Wild, 1,2,3 Janine F. Felix, 4 Arne Schillert, 5,6 Alexander Teumer, 7,8 ...
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The role of the histone variant H2A Z in early Xenopus laevis development
... 1.1.3.4 Histone variants The canonical histones make up the bulk of the histone content in all mitotic eukaryotic cells and are defined by several features: they have multiple gene copies in ...
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Saccharomyces cerevisiae Histone H2A Ser122 Facilitates DNA Repair
... chromatin structure are involved in the detection and repair of DNA ...yeast histone H2A is important for double-strand-break ...another histone H2A serine residue (Ser122) that is ...
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Abnormal level of CUL4B-mediated histone H2A ubiquitination causes disruptive HOX gene expression
... This implies that CUL4B interacts with RORγ and altera- tions in HOX genes expression in human NT2/D1 cells. RORγ is required for activation of HOX genes expression during RA‑induced differentiation human NT2/D1 cells To ...
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Conservation and function of the histone methyltransferase Set2
... conserved histone, H4, has not been ...of histone proteins, occurs on all four core histone proteins and has been shown to control many aspects of chromatin structure and ...2007), ...
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Expression and functionality of histone H2A variants in cancer
... Other H2A family members have also been found altered in cancer, but their function remains ...understand histone H2A variants, their contribution to normal cellular function and ...
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Changes in the nuclear deposition of histone H2A variants during pre implantation development in mice
... although H2A and all variants were deposited in the nuclei of full- grown oocytes, only histone ...of histone H2A and the absence of H2A.Z. The decline in H2A and the depletion ...
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The many faces of ubiquitinated histone H2A: insights from the DUBs
... Concluding remarks Overall, the discussed data show that uH2A impacts on several important aspects of cellular physiology. Although recent work provides crucial insights, we are just starting to decipher the role of ...
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Histone variants: are they functionally heterogeneous?
... of histone H1 knockouts in mice ([36] and ...H1 variants does not affect viabil- ity or ...remaining histone H1 genes resulted in a normal, or near normal, stoichiometry of total H1 histone to ...
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Histone variants in pluripotency and disease
... which histone variants can be incorporated into the chromatin landscape, in particular how the replication-independent nature of their deposition differs from that of the canonical histones, the expression ...
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Systematic quantitative analysis of H2A and H2B variants by targeted proteomics
... between histone sequences makes it challenging to differentiate canonical histones and their variants at the protein level via antibody-based ...simultaneously histone variants with high ...
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Downregulation of histone H2A and H2B pathways is associated with anthracycline sensitivity in breast cancer
... Histone H2A and H2B variants are emerging as media- tors of drug sensitivity and resistance in cancer [22, ...two histone variants contributing to the dysregula- tion signature did not ...
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Diverse Roles for Histone H2A Modifications in DNA Damage Response Pathways in Yeast
... a histone octamer (two copies each of histones H2A, H2B, H3, and ...Chromatin structure plays a dy- namic and central role in regulating transcription, DNA replication, repair, and ...the ...
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Histone H3 Variants in Trichomonas vaginalis
... H3 variants (TVAG_185390, TVAG_224460) might serve as a marker of trichomonad centromeres ...H3 variants lack a conserved sequence motif, but their pro- tein sequences share several specific features (1, ...
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A unified phylogeny-based nomenclature for histone variants
... unique variants on an organism-spe- cific basis without implying phylogenetic ...numbered variants, as in mammalian H1s, we encourage the adop- tion of paralog numbers that are consistent with known ...
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HistoneDB 2.0: a histone database with variants an integrated resource to explore histones and their variants
... (H1) histone proteins are responsible for this compaction through the formation of nucleosomes and higher order chromatin ...specific histone variants and histone post-translational modifi- ...
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Phosphorylation and arginine methylation mark histone H2A prior to deposition during Xenopus laevis development
... of H2A deposition in early embryos likely has strong roles in regulating pluripotency and dif- ferentiation ...canonical H2A is consistent with the observation in mouse embryos and stem ...the ...
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