histone methyltransferase
Histone demethylase KDM2B upregulates histone methyltransferase EZH2 expression and contributes to the progression of ovarian cancer in vitro and in vivo
... The increased expression of KDM2B in ovarian cancer was associated with histological type, tumor grade, FIGO stage, and lymph node metastasis, and it was positively correlated with EZH2. KDM2B depletion reduced the ...
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The histone methyltransferase Setd7 promotes pancreatic progenitor identity
... differentiate into definitive endoderm (DE) and PaE (Fig. 5D). ChIP analysis showed increased RNA polymerase II (PoI II) binding at the promoter regions of Foxa2, Eomes and Pdx1 in PaE differentiated cells compared with ...
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Position-specific intron retention is mediated by the histone methyltransferase SDG725
... Several lines of evidence support the notion that H3K36me2 in rice probably serves as the functional coun- terpart of H3K36me3 in animal cells [4, 16, 17]. H3K36me2 in plants and H3K36me3 in animals share similar ...
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Targeting histone methyltransferase and demethylase in acute myeloid leukemia therapy
... or histone methylation and demethylation (EZH2, MLL, DOT1L) are frequently mutated in primary and secondary ...some histone demethylases, such as LSD1, are frequently overexpressed in ...the histone ...
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Histone methyltransferase SMYD2: ubiquitous regulator of disease
... Similarly, in muscle, SMYD2 methylates Hsp90 to main- tain the stability of titin and muscle function (Fig. 3a) [54]. This discrepancy in heart development between mice and zebrafish may be due to the following reasons: ...
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Genomic Disruption of the Histone Methyltransferase SETD2 in Chronic Lymphocytic Leukemia
... on histone H3 (H3K36me3), 31,32 a mark that is associated with actively tran- scribed regions and is involved in transcriptional elongation and ...epigenetic histone mark to other important cellular ...
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Molecular function and regulation of the histone methyltransferase, Ezh2
... EZH2 (Enhancer of zeste 2) is an important developmental regulator that plays an important role in numerous biological processes including multi-cellular development, stem cell biology, and cancer development. As an ...
179
Barrier to Autointegration Factor 1 (BAF/BANF1) Promotes Association of the SETD1A Histone Methyltransferase with Herpes Simplex Virus Immediate Early Gene Promoters
... mark histone and its correspond- ing histone methyltransferase SETD1A (KMT2F) on viral IE gene promoters, arguing that BAF regulates HSV gene expression epi- genetically but that its mechanism is ...
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Interaction of DNA demethylase and histone methyltransferase upregulates Nrf2 in 5-fluorouracil-resistant colon cancer cells
... subunits [14]. The active form (proteolytic fragments) of HCF1 was increased in SNUC5/5-FUR cells (Figure 3A) and immunoprecipitation (IP) revealed a greater percentage of HCF1 and MLL were found in complex together in ...
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Oncogenic roles of the SETDB2 histone methyltransferase in gastric cancer
... SETDB2 is a histone H3 lysine 9 (H3K9) tri-methyltransferase that is involved in transcriptional gene silencing. Since it is still unknown whether SETDB2 is linked to carcinogenesis, we studied alterations ...
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Structure and catalytic mechanism of the human histone methyltransferase SET7/9
... from the AdoMet to the amine is pointing into the lysine-binding channel (see Fig. 2a). At the peptide-binding site, the channel surface is largely made up by the side chains of Leu 267 and Tyr residues 305, 335 and 337 ...
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Histone methyltransferase PRMT6 plays an oncogenic role of in prostate cancer
... arginine methyltransferase 6 (PRMT6), which was overexpressed, eventually discriminating normal from tumorous prostate tissues ...arginine methyltransferase, displays high affinity for R2 of H3, exclusively ...
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TALEN Mediated FLAG Tagging of Endogenous Histone Methyltransferase DOT1L
... Histone lysine methylations play a key role in gene transcription [1] [2] [3] and they are catalyzed by a group of histone lysine methyltransferases (KMTs). Yeast Dot1 (disruptor of telomeric silencing; or ...
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Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis
... core histone tails, resulting in chromatin compaction ...catalyzes histone H3 lysine 27 trimethylation (H3K27me3), which is enriched at transcription start sites (TSSs) of repressed genes ...
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Conservation and function of the histone methyltransferase Set2
... H3K36 methyltransferase in vitro, but whether it functions as such in vivo has yet to be determined (Rayasam et ...H3K36 methyltransferase that interacts with elongating RNAPII (Sun et ...H3K36 ...
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Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis
... that histone reader BS69 specif- ically recognizes that SETD2 catalyzes ...by histone modifications, which will shed insights on the role of SETD2 in the regulation of splicing as well as ...
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EHMT1 mosaicism in apparently unaffected parents is associated with autism spectrum disorder and neurocognitive dysfunction
... Kleefstra syndrome (KS; OMIM #610253) is caused by haploinsufficiency of the euchromatin histone methyltransferase 1 (EHMT1) gene located at chromo- some 9q34.3. Almost all cases of KS are due to de novo ...
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Characterization of the grappa Gene, the Drosophila Histone H3 Lysine 79 Methyltransferase
... a histone methyltransferase that modifies the lysine (K)79 residue of histone ...early histone H3 K4 and K9 methylation patterns, the appearance of methylated K79 during embryogenesis ...
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DNA Replication Origin Function Is Promoted by H3K4 Di-methylation in Saccharomyces cerevisiae
... identify histone post-translational modifications important for DNA replication, we initiated a genetic screen to identify interactions between genes encoding chromatin-modifying enzymes and those encoding proteins ...
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Dot1l expression predicts adverse postoperative prognosis of patients with clear-cell renal cell carcinoma
... play a crucial role in this progress [28]. In addition, Dot1l has some other regulatory functions, which may have something to do with cancer, such as inhibition of somatic reprogramming [29] and promotion in DNA damage ...
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