HIV-1 coreceptor
Clinical significance of HIV 1 coreceptor usage
... of HIV-1 coreceptor usage The identification of viral genotypic changes associated with different coreceptor usage has led to the develop- ment of sequence-based algorithms to predict corecep- ...
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HIV 1 coreceptor usage prediction without multiple alignments: an application of string kernels
... for HIV-1 coreceptor usage ...CCR5 coreceptor inhibi- tors and CXCR4 coreceptor inhibitors, in clinical ...receptor/ coreceptor prior to infection is not specific to ...
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Insights Into Hiv-1 Coreceptor Engagement And Its Contribution To Membrane Fusion
... During HIV-1 entry, CD4 and a coreceptor (either CCR5 or CXCR4) must interact with the envelope glycoprotein ...The coreceptor N-terminus and extracellular loops are critical domains that ...
150
R5X4 HIV 1 coreceptor use in primary target cells: implications for coreceptor entry blocking strategies
... determine coreceptor use by R5X4 strains on primary cells, it may be possible to modify these methods to increase their ...ing coreceptor use by R5X4 strains on primary lympho- cytes and ...mimics ...
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Sensitive Cell Based Assay for Determination of Human Immunodeficiency Virus Type 1 Coreceptor Tropism
... genotypic HIV-1 tropism assays to detect non-R5 variants (64– ...for HIV-1 coreceptor tropism assays resulted in the detection of minor variants, which correlated well with both ...
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Evaluation of Eight Different Bioinformatics Tools To Predict Viral Tropism in Different Human Immunodeficiency Virus Type 1 Subtypes
... some HIV-1 clades were not or only scarcely ...determining HIV-1 coreceptor usage in pairwise plasma samples has recently been highlighted, being of up to 15% in one recent study ...of ...
5
The amino terminal domain of the CCR2 chemokine receptor acts as coreceptor for HIV 1 infection
... for HIV-1 infection, assign these molecules a key role in HIV-1 pathogenesis ...protein 1 (MCP-1), a CC chemokine family member, is produced by endothelial cells, smooth muscle, ...
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Influence of the CCR2-V64I Polymorphism on Human Immunodeficiency Virus Type 1 Coreceptor Activity and on Chemokine Receptor Function of CCR2b, CCR3, CCR5, and CXCR4
... type 1 (HIV-1) in conjunction with CD4 to infect ...and HIV-1 coreceptor activities, and their effects on the expression and receptor activities of the major HIV-1 ...
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Preferential suppression of CXCR4 specific strains of HIV 1 by antiviral therapy
... indicate HIV-1 coreceptor usage in a semi- quantitative manner ...(Figure 1), and one displayed virus that exclu- sively used ...Figure 1 by patient 13, who remained untreated ...
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CXCR4 expression during lymphopoiesis: implications for human immunodeficiency virus type 1 infection of the thymus.
... and HIV-1 ...of HIV-1 in thymocyte subsets correlated with CXCR4 ...the HIV-1 coreceptor CXCR4 in these less ma- ture CD4 1 thymocyte populations, in particular the ...
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P2X1 Receptor Antagonists Inhibit HIV-1 Fusion by Blocking Virus-Coreceptor Interactions
... the coreceptor CXCR4 or ...promote HIV-1 fusion, other host factors can modulate this ...of HIV-1 fusion by selective P2X1 receptor antagonists, in- cluding NF279, and suggested that ...
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The Cytomegalovirus-Encoded Chemokine Receptor US28 Can Enhance Cell-Cell Fusion Mediated by Different Viral Proteins
... of HIV-1 infectivity when US28 was expressed in HIV-1-producing cells or in CD4 1 target cells (besides HIV-1 coreceptor ...
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Expression and Use of Human Immunodeficiency Virus Type 1 Coreceptors by Human Alveolar Macrophages
... on HIV-1 coreceptor expression, chemokine expression, and the ability of AM to be infected by primary isolates of ...for HIV-1 coreceptor expression by Northern ...on ...
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A genotypic HIV-1 proviral DNA coreceptor tropism assay: characterization in viremic subjects
... of HIV-1 tropism ...cellular HIV DNA load predicts HIV DNA decline and residual HIV plasma levels during effective antiretroviral ...
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Alternative Coreceptor Requirements for Efficient CCR5- and CXCR4-Mediated HIV-1 Entry into Macrophages
... primary HIV-1 isolates and, thus, may carry muta- tions that are the result of virus culture which may not be relevant for replication in ...of coreceptor engagement that are re- quired for CCR5- and ...
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Pace of Coreceptor Tropism Switch in HIV-1-Infected Individuals after Recent Infection
... ics, viral load, CD4 ⫹ and CD8 ⫹ T cell counts, CCR5Δ32 polymorphisms, GB virus C (GBV-C) coinfection, and HLA profiles were also evaluated. Ultradeep sequencing was performed on initial samples from 11 selected ...
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Conformational HIV 1 Envelope on particulate structures: a tool for chemokine coreceptor binding studies
... although HIV-1 Gag proteins fused to full-length HIV Reverse Transcriptase (RT) protein, without loosing the capability of assem- bling into VLPs, have been recently reported ...
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Macrophage Tropism of Human Immunodeficiency Virus Type 1 Isolates from Brain and Lymphoid Tissues Predicts Neurotropism Independent of Coreceptor Specificity
... type 1 (HIV-1) neurotropism are unknown, due in part to limited studies on viruses isolated from ...understand HIV-1 neurotropism, we isolated primary viruses from autopsy brain, ...
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Unique Phenotypic Characteristics of Recently Transmitted HIV-1 Subtype C Envelope Glycoprotein gp120: Use of CXCR6 Coreceptor by Transmitted Founder Viruses
... an HIV- infected individual are not necessarily infectious or capable of establishing a productive infection (14) and that just a few viruses or even a single virus particle with enormous transmission fitness is ...
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Platelet activation suppresses HIV 1 infection of T cells
... for HIV-1 ...inhibits HIV-1 but not HIV-2 and SIV entry ...of HIV-1 and MLV Env pseudotypes by supernatants from activated ...by HIV-1 or MLV Env but had ...
10