HLA-class II antigen
Intestinal epithelial cells use two distinct pathways for HLA class II antigen processing
... of HLA class II mole- cules, but also the invariant chain (Ii), the HLA-DM ab het- erodimer, and a series of proteases that facilitate partial pro- teolysis of both internalized ...
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Highly polarized HLA class II antigen processing and presentation by human intestinal epithelial cells
... stimulating antigen processing by T84 cells, g -IFN treatment has been observed to elicit a profound and relatively rapid decrease in TER in T84 monolayers without an immediate alteration in cell morphology or ...
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A humanized model of experimental autoimmune uveitis in HLA class II transgenic mice
... Interestingly, HLA-DR3 TG mice immunized with bS-Ag developed very severe disease, with many individual mice reaching disease scores of 4, corresponding to complete destruction of the photoreceptor cell layer and ...
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Association of HLA class I and II genes with cutaneous leishmaniasis: a case control study from Sri Lanka and a systematic review
... leukocyte antigen (HLA) genes of class I and II located within the MHC, encode molecules identified for their role in presentation of antigens to CD8 + and CD4 + T cells ...MHC class I ...
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Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B
... and/or antigen load may be an important cause of the T cell hyporesponsiveness to hepatitis B virus (HBV) antigens that is often observed in patients with chronic HBV ...and antigen load by lami- vudine ...
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The Human Leukocyte Antigen (HLA) DRB1*13:02 Allele Protects against Dementia in Continental Western Europe
... of HLA class II genes is to aid in the elimination of pathogens by enabling the production of antibodies against their antigens in specific immunity, the protective effect of DRB1*13:02 points to the ...
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Dendritic Cells and Macrophages Are Productively Infected by Poliovirus
... allow antigen presentation on HLA class I (4, 20) and class II (19) molecules following uptake by unaf- fected cells and to induce stimulation of antigen-specific CD8 and CD4 T ...
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Human histocompatibility leukocyte antigen (HLA) haplotype frequencies estimated from the data on HLA class I, II, and III antigens in 111 Japanese narcoleptics
... Haplotype analysis on six families showed that B35-DR2 and other rare haplotypes in normal Japanese were associated with narcolepsy.. There were four cases without any signs of narcoleps[r] ...
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The interaction of HLA-DM with conventional MHC class II molecules
... of HLA-DO in a more physiological setting, L iljedahl et ...of HLA-DO (Liljedahl et ...in antigen presentation, the lack o f DO rather seem ed to lead to a modulation of the antigen ...
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HLA-DRB1 Class II antigen level alleles are associated with persistent HPV infection in Mexican women; a pilot study
... On the other hand, when comparing the HPV-cleared group against the external healthy individuals group [27] in order to explore the role of the HLA gene in viral clearance, an increase in the g.f. of the DRB1*07 ...
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Interaction of the proteins which regulate MHC class II-mediated antigen presentation by antigen presenting cells
... both HLA-DM and HLA-DR3 are pH sensitive and that the interaction between purified DM and DR3/CLIP complex at pH5 was 6- to 7-fold higher than at ...I-Ad class II molecules for ...I-Ad ...
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Natural T-cell ligands that are created by genetic variants can be transferred between cells by extracellular vesicles
... from HLA class II-negative infected or transformed cells need to be transferred to surrounding APC in order to prime naive CD4 T ...of antigen transfer is well known from solid organ ...
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The HLA DPB1*02:01:02 and DQB1*05:02:01 alleles as possible risk factors for colorectal carcinoma in the Malaysian population
... polymorphic HLA class II DRB, DQB and DPB genes might be susceptible or resistant to specific types of cancers (17, 18, 22, ...in HLA is often associated with susceptibility to particular ...
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The class I and class II antigen systems in cattle and their association with disease
... DR antigen matched donor - recipient pairs survived the first ...DR antigen specificity was common to both donor and recipient and this survival percentage dropped to between 18-30% between unmatched donor ...
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Diversity and Frequencies of HLA Class I and Class II Genes of an East African Population
... Leukocyte Antigen (HLA) genes are the most polymorphic genes within the human genome and play an important role in initiating the immune response to invading ...specific HLA alleles and ...
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Genetic Polymorphisms HLA Class II in SIRS and Sepsis in Children
... whole HLA complex had been sequenced ...These HLA -DRB1; DQA1; DQB1– genes are positioned next to each other within the cluster of HLA class II ...
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HLA Class II Profile and Distribution of HLA-DRB1 and HLA-DQB1 Alleles and Haplotypes among Lebanese and Bahraini Arabs
... Bahraini HLA class II alleles and haplotypes revealed some relatedness to their Lebanese counterparts and also to those of neighboring and distant ethnic groups, as exemplified by DRB1*1101 and ...
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Splice acceptor site mutation of the transporter associated with antigen processing 1 gene in human bare lymphocyte syndrome
... leukocyte antigen (HLA) class I molecules on the cell surface depends on the heterodimer of the transporter associated with antigen processing 1 and 2 (TAP1 and TAP2), which transport peptides ...
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Aspects of the cell biology of antigen processing for MHC II
... MHC II which are derived from molecules not normally found outside plasma membrane and early ...MHC II in early endosomes in such a way as to enhance their ...MHC II, both of which are ...
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<p>Major histocompatibility complex class II molecule in non-small cell lung cancer diagnosis, prognosis and treatment</p>
... MHC class II expression in peripheral blood was also analyzed in lung cancer ...34,49–52 HLA-DR9 was found to have higher frequency in peripheral blood of lung cancer patients, while HLA-DR6 ...
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